Variations in dysfunction of sister chromatid cohesion in esco2 mutant zebrafish reflect the phenotypic diversity of Roberts syndrome

Variations in dysfunction of sister chromatid cohesion in esco2 mutant zebrafish reflect the phenotypic diversity of Roberts syndrome

Mutations in ESCO2, one of two establishment of cohesion factors necessary for proper sister chromatid cohesion (SCC), cause a spectrum of developmental defects in the autosomal-recessive disorder Roberts syndrome (RBS), warranting in vivo analysis of the consequence of cohesion dysfunction. Through...

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Bibliographic Details
Main Authors: Stefanie M. Percival, Holly R. Thomas, Adam Amsterdam, Andrew J. Carroll, Jacqueline A. Lees, H. Joseph Yost, John M. Parant
Format: Article
Language:English
Published: The Company of Biologists 2015-08-01
Series:Disease Models & Mechanisms
Subjects:
esco2
Sister chromatid cohesion
In vivo imaging
Zebrafish
p53
Genomic instability
Aneuploidy
Online Access:http://dmm.biologists.org/content/8/8/941

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