Characterization of the effect of histone deacetylation inhibitors on CD8+ T cells in the context of aging

Characterization of the effect of histone deacetylation inhibitors on CD8+ T cells in the context of aging

Abstract Background Posttranslational protein modifications regulate essential cellular processes, including the immune cell activation. Despite known age-related alterations of the phenotype, composition and cytokine profiles of immune cells, the role of acetylation in the aging process of the immu...

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Bibliographic Details
Main Authors: Georgiana Toma, Eliza Karapetian, Chiara Massa, Dagmar Quandt, Barbara Seliger
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Journal of Translational Medicine
Subjects:
Histone deacetylase inhibitors
CD8+ T cells
Protein identification
Acetylation
Aging
Online Access:https://doi.org/10.1186/s12967-022-03733-9

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