Veterinary Regenerative Medicine for Musculoskeletal Disorders: Can Mesenchymal Stem/Stromal Cells and Their Secretome Be the New Frontier?
Regenerative medicine aims to restore the normal function of diseased or damaged cells, tissues, and organs using a set of different approaches, including cell-based therapies. In the veterinary field, regenerative medicine is strongly related to the use of mesenchymal stromal cells (MSCs), which be...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/6/1453 |
| _version_ | 1797565536684474368 |
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| author | Michela Mocchi Silvia Dotti Maurizio Del Bue Riccardo Villa Elia Bari Sara Perteghella Maria Luisa Torre Stefano Grolli |
| author_facet | Michela Mocchi Silvia Dotti Maurizio Del Bue Riccardo Villa Elia Bari Sara Perteghella Maria Luisa Torre Stefano Grolli |
| author_sort | Michela Mocchi |
| collection | DOAJ |
| description | Regenerative medicine aims to restore the normal function of diseased or damaged cells, tissues, and organs using a set of different approaches, including cell-based therapies. In the veterinary field, regenerative medicine is strongly related to the use of mesenchymal stromal cells (MSCs), which belong to the body repair system and are defined as multipotent progenitor cells, able to self-replicate and to differentiate into different cell types. This review aims to take stock of what is known about the MSCs and their use in the veterinary medicine focusing on clinical reports on dogs and horses in musculoskeletal diseases, a research field extensively reported in the literature data. Finally, a perspective regarding the use of the secretome and/or extracellular vesicles (EVs) in the veterinary field to replace parental MSCs is provided. The pharmaceuticalization of EVs is wished due to the realization of a Good Manufacturing Practice (GMP product suitable for clinical trials. |
| first_indexed | 2024-03-10T19:14:37Z |
| format | Article |
| id | doaj.art-fccc66cacf5e41e6b0b32a7c9c3a5394 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T19:14:37Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-fccc66cacf5e41e6b0b32a7c9c3a53942023-11-20T03:33:49ZengMDPI AGCells2073-44092020-06-0196145310.3390/cells9061453Veterinary Regenerative Medicine for Musculoskeletal Disorders: Can Mesenchymal Stem/Stromal Cells and Their Secretome Be the New Frontier?Michela Mocchi0Silvia Dotti1Maurizio Del Bue2Riccardo Villa3Elia Bari4Sara Perteghella5Maria Luisa Torre6Stefano Grolli7Department of Drug Sciences, University of Pavia, 27100 Pavia, ItalyIstituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, 25124 Brescia, ItalyFreelance Veterinary Medical Doctor, 43121 Parma, ItalyIstituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, 25124 Brescia, ItalyDepartment of Drug Sciences, University of Pavia, 27100 Pavia, ItalyDepartment of Drug Sciences, University of Pavia, 27100 Pavia, ItalyDepartment of Drug Sciences, University of Pavia, 27100 Pavia, ItalyDepartment of Veterinary Medical Science, University of Parma, 43121 Parma, ItalyRegenerative medicine aims to restore the normal function of diseased or damaged cells, tissues, and organs using a set of different approaches, including cell-based therapies. In the veterinary field, regenerative medicine is strongly related to the use of mesenchymal stromal cells (MSCs), which belong to the body repair system and are defined as multipotent progenitor cells, able to self-replicate and to differentiate into different cell types. This review aims to take stock of what is known about the MSCs and their use in the veterinary medicine focusing on clinical reports on dogs and horses in musculoskeletal diseases, a research field extensively reported in the literature data. Finally, a perspective regarding the use of the secretome and/or extracellular vesicles (EVs) in the veterinary field to replace parental MSCs is provided. The pharmaceuticalization of EVs is wished due to the realization of a Good Manufacturing Practice (GMP product suitable for clinical trials.https://www.mdpi.com/2073-4409/9/6/1453mesenchymal stem cellsregenerative medicineveterinarysecretomeextracellular vesiclesmicrovesicles |
| spellingShingle | Michela Mocchi Silvia Dotti Maurizio Del Bue Riccardo Villa Elia Bari Sara Perteghella Maria Luisa Torre Stefano Grolli Veterinary Regenerative Medicine for Musculoskeletal Disorders: Can Mesenchymal Stem/Stromal Cells and Their Secretome Be the New Frontier? Cells mesenchymal stem cells regenerative medicine veterinary secretome extracellular vesicles microvesicles |
| title | Veterinary Regenerative Medicine for Musculoskeletal Disorders: Can Mesenchymal Stem/Stromal Cells and Their Secretome Be the New Frontier? |
| title_full | Veterinary Regenerative Medicine for Musculoskeletal Disorders: Can Mesenchymal Stem/Stromal Cells and Their Secretome Be the New Frontier? |
| title_fullStr | Veterinary Regenerative Medicine for Musculoskeletal Disorders: Can Mesenchymal Stem/Stromal Cells and Their Secretome Be the New Frontier? |
| title_full_unstemmed | Veterinary Regenerative Medicine for Musculoskeletal Disorders: Can Mesenchymal Stem/Stromal Cells and Their Secretome Be the New Frontier? |
| title_short | Veterinary Regenerative Medicine for Musculoskeletal Disorders: Can Mesenchymal Stem/Stromal Cells and Their Secretome Be the New Frontier? |
| title_sort | veterinary regenerative medicine for musculoskeletal disorders can mesenchymal stem stromal cells and their secretome be the new frontier |
| topic | mesenchymal stem cells regenerative medicine veterinary secretome extracellular vesicles microvesicles |
| url | https://www.mdpi.com/2073-4409/9/6/1453 |
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