The choroid plexuses and their impact on developmental neurogenesis.
During brain development the neural stem cells are regulated by both intrinsic and extrinsic sources. One site of origin of extrinsic regulation is the developing choroid plexuses, primely situated inside the cerebral ventricles. The choroid plexuses are very active in terms of both secretion and ba...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-10-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00340/full |
| _version_ | 1818940243980582912 |
|---|---|
| author | Pia Annette Johansson |
| author_facet | Pia Annette Johansson |
| author_sort | Pia Annette Johansson |
| collection | DOAJ |
| description | During brain development the neural stem cells are regulated by both intrinsic and extrinsic sources. One site of origin of extrinsic regulation is the developing choroid plexuses, primely situated inside the cerebral ventricles. The choroid plexuses are very active in terms of both secretion and barrier function as soon as they appear during development and control the production and contents of cerebrospinal fluid (CSF). This suggests that regulated secretion of signaling molecules from the choroid plexuses into CSF can regulate neural stem cell behavior (as they are in direct contact with CSF) and thereby neurogenesis and brain development. Here, choroid plexus development, particularly with regards to molecular regulation and specification, is reviewed. This is followed by a review and discussion of the role of the developing choroid plexuses in brain development. In particular, recent evidence suggests a region-specific reciprocal regulation between choroid plexuses and the neural stem cells. This is accomplished by site-specific secretion of signaling molecules from the different choroid plexuses into CSF, as well as brain region specific competence of the neural stem cells to respond to the signaling molecules present in CSF. In conclusion, although in its infancy, the field of choroid plexus regulation of neurogenesis has already and will likely continue to shed new light on our understanding of the control and fine-tuning of overall brain development. |
| first_indexed | 2024-12-20T06:36:33Z |
| format | Article |
| id | doaj.art-fccd9dfc58fd462e8c757160b4731fb8 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-20T06:36:33Z |
| publishDate | 2014-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-fccd9dfc58fd462e8c757160b4731fb82022-12-21T19:50:00ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2014-10-01810.3389/fnins.2014.00340112716The choroid plexuses and their impact on developmental neurogenesis.Pia Annette Johansson0Helmholtz-Zentrum MünchenDuring brain development the neural stem cells are regulated by both intrinsic and extrinsic sources. One site of origin of extrinsic regulation is the developing choroid plexuses, primely situated inside the cerebral ventricles. The choroid plexuses are very active in terms of both secretion and barrier function as soon as they appear during development and control the production and contents of cerebrospinal fluid (CSF). This suggests that regulated secretion of signaling molecules from the choroid plexuses into CSF can regulate neural stem cell behavior (as they are in direct contact with CSF) and thereby neurogenesis and brain development. Here, choroid plexus development, particularly with regards to molecular regulation and specification, is reviewed. This is followed by a review and discussion of the role of the developing choroid plexuses in brain development. In particular, recent evidence suggests a region-specific reciprocal regulation between choroid plexuses and the neural stem cells. This is accomplished by site-specific secretion of signaling molecules from the different choroid plexuses into CSF, as well as brain region specific competence of the neural stem cells to respond to the signaling molecules present in CSF. In conclusion, although in its infancy, the field of choroid plexus regulation of neurogenesis has already and will likely continue to shed new light on our understanding of the control and fine-tuning of overall brain development.http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00340/fullCerebral CortexCerebrospinal FluidChoroid PlexusNeural Stem CellsNeurogenesisBrain Development |
| spellingShingle | Pia Annette Johansson The choroid plexuses and their impact on developmental neurogenesis. Frontiers in Neuroscience Cerebral Cortex Cerebrospinal Fluid Choroid Plexus Neural Stem Cells Neurogenesis Brain Development |
| title | The choroid plexuses and their impact on developmental neurogenesis. |
| title_full | The choroid plexuses and their impact on developmental neurogenesis. |
| title_fullStr | The choroid plexuses and their impact on developmental neurogenesis. |
| title_full_unstemmed | The choroid plexuses and their impact on developmental neurogenesis. |
| title_short | The choroid plexuses and their impact on developmental neurogenesis. |
| title_sort | choroid plexuses and their impact on developmental neurogenesis |
| topic | Cerebral Cortex Cerebrospinal Fluid Choroid Plexus Neural Stem Cells Neurogenesis Brain Development |
| url | http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00340/full |
| work_keys_str_mv | AT piaannettejohansson thechoroidplexusesandtheirimpactondevelopmentalneurogenesis AT piaannettejohansson choroidplexusesandtheirimpactondevelopmentalneurogenesis |