Chemoreactomic analysis of citrulline malate molecules
Citrulline malate that is essential for the biosynthesis of arginine promotes dehydration of ammonium endotoxins, by participating in the urea cycle. The indications for the use of citrulline malate are functional asthenia, asthenic syndrome, overfatigue, increased fatigue, and rehabilitation during...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2017-07-01
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| Series: | Неврология, нейропсихиатрия, психосоматика |
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| Online Access: | https://nnp.ima-press.net/nnp/article/view/743 |
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| author | I. Yu. Torshin O. A. Gromova L. E. Fedotova A. N. Gromov K. V. Rudakov |
| author_facet | I. Yu. Torshin O. A. Gromova L. E. Fedotova A. N. Gromov K. V. Rudakov |
| author_sort | I. Yu. Torshin |
| collection | DOAJ |
| description | Citrulline malate that is essential for the biosynthesis of arginine promotes dehydration of ammonium endotoxins, by participating in the urea cycle. The indications for the use of citrulline malate are functional asthenia, asthenic syndrome, overfatigue, increased fatigue, and rehabilitation during recovery following diseases.Objective: to simulate the biological properties of citrulline malate.Material and methods. Reliable estimates of more than 2,500 biological activities were obtained for this molecule, which were compared with those of the reference molecules of acetylcarnitine and meldonium.Results and discussion. The data obtained from chemoreactome simulation may suggest that there are substantial differences between the pharmacological effects of citrulline malate and the reference molecules. Malate anion as a component of citrulline malate significantly enhances the absorption of citrulline molecules in the gastrointestinal tract regardless of gastric acidity. Citrulline malate improves renal bicarbonate anion absorption, which contributes to the overcoming of acidosis. The results of chemoreactome simulation indicate that citrulline malate has antidepressant, anxiolytic, and anti-inflammatory properties, which can make a substantial contribution to the development of anti-asthenic and detoxifying effects of the drug. Citrulline malate can also show anticoagulant, antivasopressor, hypoglycemic, antihypercholesterolemic, and antimicrobial effects. These properties of citrulline malate can contribute to the earliest recovery of patients after asthenia or intensive strenuous exercises as compared to those of the reference molecules (meldonium, acetylcarnitine).Conclusion. The findings are consistent with the available experimental and clinical data and are indicative of promising clinical applications of citrulline malate. |
| first_indexed | 2024-04-10T02:02:36Z |
| format | Article |
| id | doaj.art-fcd23a15d6fb41e2a1e05932899b6332 |
| institution | Directory Open Access Journal |
| issn | 2074-2711 2310-1342 |
| language | Russian |
| last_indexed | 2024-04-10T02:02:36Z |
| publishDate | 2017-07-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Неврология, нейропсихиатрия, психосоматика |
| spelling | doaj.art-fcd23a15d6fb41e2a1e05932899b63322023-03-13T08:42:16ZrusIMA-PRESS LLCНеврология, нейропсихиатрия, психосоматика2074-27112310-13422017-07-0192303510.14412/2074-2711-2017-2-30-35654Chemoreactomic analysis of citrulline malate moleculesI. Yu. Torshin0O. A. Gromova1L. E. Fedotova2A. N. Gromov3K. V. Rudakov4Moscow Institute of Physics and Technology, Dolgoprudnyi, Moscow RegionIvanovo State Medical Academy, Ministry of Health of Russia, IvanovoIvanovo State Medical Academy, Ministry of Health of Russia, IvanovoFederal Research Center of Informatics and Management, Russian Academy of Sciences, MoscowMoscow Institute of Physics and Technology, Dolgoprudnyi, Moscow RegionCitrulline malate that is essential for the biosynthesis of arginine promotes dehydration of ammonium endotoxins, by participating in the urea cycle. The indications for the use of citrulline malate are functional asthenia, asthenic syndrome, overfatigue, increased fatigue, and rehabilitation during recovery following diseases.Objective: to simulate the biological properties of citrulline malate.Material and methods. Reliable estimates of more than 2,500 biological activities were obtained for this molecule, which were compared with those of the reference molecules of acetylcarnitine and meldonium.Results and discussion. The data obtained from chemoreactome simulation may suggest that there are substantial differences between the pharmacological effects of citrulline malate and the reference molecules. Malate anion as a component of citrulline malate significantly enhances the absorption of citrulline molecules in the gastrointestinal tract regardless of gastric acidity. Citrulline malate improves renal bicarbonate anion absorption, which contributes to the overcoming of acidosis. The results of chemoreactome simulation indicate that citrulline malate has antidepressant, anxiolytic, and anti-inflammatory properties, which can make a substantial contribution to the development of anti-asthenic and detoxifying effects of the drug. Citrulline malate can also show anticoagulant, antivasopressor, hypoglycemic, antihypercholesterolemic, and antimicrobial effects. These properties of citrulline malate can contribute to the earliest recovery of patients after asthenia or intensive strenuous exercises as compared to those of the reference molecules (meldonium, acetylcarnitine).Conclusion. The findings are consistent with the available experimental and clinical data and are indicative of promising clinical applications of citrulline malate.https://nnp.ima-press.net/nnp/article/view/743citrulline malateacetylcarnitinemeldoniumchemoreactome simulationbioinformatics |
| spellingShingle | I. Yu. Torshin O. A. Gromova L. E. Fedotova A. N. Gromov K. V. Rudakov Chemoreactomic analysis of citrulline malate molecules Неврология, нейропсихиатрия, психосоматика citrulline malate acetylcarnitine meldonium chemoreactome simulation bioinformatics |
| title | Chemoreactomic analysis of citrulline malate molecules |
| title_full | Chemoreactomic analysis of citrulline malate molecules |
| title_fullStr | Chemoreactomic analysis of citrulline malate molecules |
| title_full_unstemmed | Chemoreactomic analysis of citrulline malate molecules |
| title_short | Chemoreactomic analysis of citrulline malate molecules |
| title_sort | chemoreactomic analysis of citrulline malate molecules |
| topic | citrulline malate acetylcarnitine meldonium chemoreactome simulation bioinformatics |
| url | https://nnp.ima-press.net/nnp/article/view/743 |
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