Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury
The recovery of function upon acute kidney injury is thought to involve tubular cell dedifferentiation and proliferation. Here the authors show that Pax2+ progenitors regenerate tubules via cell division while other tubular cells support function recovery by undergoing hypertrophy through endoreplic...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03753-4 |
| _version_ | 1818750656776765440 |
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| author | Elena Lazzeri Maria Lucia Angelotti Anna Peired Carolina Conte Julian A. Marschner Laura Maggi Benedetta Mazzinghi Duccio Lombardi Maria Elena Melica Sara Nardi Elisa Ronconi Alessandro Sisti Giulia Antonelli Francesca Becherucci Letizia De Chiara Ricardo Romero Guevara Alexa Burger Beat Schaefer Francesco Annunziato Hans-Joachim Anders Laura Lasagni Paola Romagnani |
| author_facet | Elena Lazzeri Maria Lucia Angelotti Anna Peired Carolina Conte Julian A. Marschner Laura Maggi Benedetta Mazzinghi Duccio Lombardi Maria Elena Melica Sara Nardi Elisa Ronconi Alessandro Sisti Giulia Antonelli Francesca Becherucci Letizia De Chiara Ricardo Romero Guevara Alexa Burger Beat Schaefer Francesco Annunziato Hans-Joachim Anders Laura Lasagni Paola Romagnani |
| author_sort | Elena Lazzeri |
| collection | DOAJ |
| description | The recovery of function upon acute kidney injury is thought to involve tubular cell dedifferentiation and proliferation. Here the authors show that Pax2+ progenitors regenerate tubules via cell division while other tubular cells support function recovery by undergoing hypertrophy through endoreplication. |
| first_indexed | 2024-12-18T04:23:09Z |
| format | Article |
| id | doaj.art-fcd2644ead064a62bdd2370d3ecae9a3 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:23:09Z |
| publishDate | 2018-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-fcd2644ead064a62bdd2370d3ecae9a32022-12-21T21:21:10ZengNature PortfolioNature Communications2041-17232018-04-019111810.1038/s41467-018-03753-4Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injuryElena Lazzeri0Maria Lucia Angelotti1Anna Peired2Carolina Conte3Julian A. Marschner4Laura Maggi5Benedetta Mazzinghi6Duccio Lombardi7Maria Elena Melica8Sara Nardi9Elisa Ronconi10Alessandro Sisti11Giulia Antonelli12Francesca Becherucci13Letizia De Chiara14Ricardo Romero Guevara15Alexa Burger16Beat Schaefer17Francesco Annunziato18Hans-Joachim Anders19Laura Lasagni20Paola Romagnani21Department of Clinical and Experimental Biomedical Sciences, University of FlorenceDepartment of Clinical and Experimental Biomedical Sciences, University of FlorenceDepartment of Clinical and Experimental Biomedical Sciences, University of FlorenceDepartment of Clinical and Experimental Biomedical Sciences, University of FlorenceDivision of Nephrology, Medizinische Klinik and Poliklinik IV, Klinikum der LMU MünchenExcellence Centre for Research, Transfer and High Education for the development of DE NOVO Therapies (DENOTHE)Nephrology Unit and Meyer Children’s University HospitalDepartment of Clinical and Experimental Biomedical Sciences, University of FlorenceDepartment of Clinical and Experimental Biomedical Sciences, University of FlorenceDepartment of Clinical and Experimental Biomedical Sciences, University of FlorenceDepartment of Clinical and Experimental Biomedical Sciences, University of FlorenceDepartment of Clinical and Experimental Biomedical Sciences, University of FlorenceDepartment of Clinical and Experimental Biomedical Sciences, University of FlorenceNephrology Unit and Meyer Children’s University HospitalNephrology Unit and Meyer Children’s University HospitalDepartment of Clinical and Experimental Biomedical Sciences, University of FlorenceInstitute of Molecular Life Sciences, University of ZurichDepartment of Oncology and Children’s Research Center, University Children’s HospitalExcellence Centre for Research, Transfer and High Education for the development of DE NOVO Therapies (DENOTHE)Division of Nephrology, Medizinische Klinik and Poliklinik IV, Klinikum der LMU MünchenDepartment of Clinical and Experimental Biomedical Sciences, University of FlorenceDepartment of Clinical and Experimental Biomedical Sciences, University of FlorenceThe recovery of function upon acute kidney injury is thought to involve tubular cell dedifferentiation and proliferation. Here the authors show that Pax2+ progenitors regenerate tubules via cell division while other tubular cells support function recovery by undergoing hypertrophy through endoreplication.https://doi.org/10.1038/s41467-018-03753-4 |
| spellingShingle | Elena Lazzeri Maria Lucia Angelotti Anna Peired Carolina Conte Julian A. Marschner Laura Maggi Benedetta Mazzinghi Duccio Lombardi Maria Elena Melica Sara Nardi Elisa Ronconi Alessandro Sisti Giulia Antonelli Francesca Becherucci Letizia De Chiara Ricardo Romero Guevara Alexa Burger Beat Schaefer Francesco Annunziato Hans-Joachim Anders Laura Lasagni Paola Romagnani Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury Nature Communications |
| title | Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury |
| title_full | Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury |
| title_fullStr | Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury |
| title_full_unstemmed | Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury |
| title_short | Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury |
| title_sort | endocycle related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury |
| url | https://doi.org/10.1038/s41467-018-03753-4 |
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