Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death

Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death

Summary: Interferon-inducible guanylate-binding proteins (GBPs) promote cell-intrinsic defense through host cell death. GBPs target pathogens and pathogen-containing vacuoles and promote membrane disruption for release of microbial molecules that activate inflammasomes. GBP1 mediates pyroptosis or a...

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Bibliographic Details
Main Authors: Daniel Fisch, Barbara Clough, Marie-Charlotte Domart, Vesela Encheva, Hironori Bando, Ambrosius P. Snijders, Lucy M. Collinson, Masahiro Yamamoto, Avinash R. Shenoy, Eva-Maria Frickel
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Cell Reports
Subjects:
apoptosis
caspases
GBP1
inflammasomes
pyroptosis
Salmonella enterica Typhimurium
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720309931

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