Adhesion molecules and cell-cytokine complex in vascular remodeling among patients with arterial hypertension and metabolic risk factors
The interaction between intercellular adhesion molecules, pro-inflammatory cytokines as apoptosis agents, and lymphocyte receptors was studied in patients with arterial hypertension (AH) and metabolic disturbances. The study involved 85 AH patients: Group I (AH and obesity, O), Group II (AH, O, and...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2008-10-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1619 |
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| author | L. R. Iskandarova E. G. Mutalova E. R. Smakaeva L. N. Mingazetdinova G. M. Sakhautdinova |
| author_facet | L. R. Iskandarova E. G. Mutalova E. R. Smakaeva L. N. Mingazetdinova G. M. Sakhautdinova |
| author_sort | L. R. Iskandarova |
| collection | DOAJ |
| description | The interaction between intercellular adhesion molecules, pro-inflammatory cytokines as apoptosis agents, and lymphocyte receptors was studied in patients with arterial hypertension (AH) and metabolic disturbances. The study involved 85 AH patients: Group I (AH and obesity, O), Group II (AH, O, and insulin resistance, IR), Group III (AH only). Integral leukocyte indices, intercellular and vascular wall adhesion molecules (ICAM-2, VCAM-1, p-selectin), lymphocyte receptors (CD16, CD25, CD95), pro-inflammatory cytokines (IL-в, IF-г, TNF-б), carbohydrate and lipid metabolism parameters were studied. Increased expression of soluble adhesion molecules sVCAM-1 and sp-selectin was observed in all AH patients, especially in Group II. Decreased levels of apoptosis initiators, CD16+(NK) and CD25+ lymphocytes with high expression of Fas-receptors (CD95) which activate neutrophil apoptosis, were observed, as well as a 2-5-fold increase in TNF concentration - a key factor in inflammation and apoptosis induction. Massive cell death and lipid accumulation is one of the main morphologic characteristics of atherosclerotic plaque, highly prevalent in patients with AH, O, and IR. Intercellular adhesion molecule expression could be regarded as endothelial cell apoptosis predictor. |
| first_indexed | 2024-04-09T20:53:50Z |
| format | Article |
| id | doaj.art-fcd563e6866d4d319b8b5eb1508bcf79 |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2025-03-14T09:34:04Z |
| publishDate | 2008-10-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-fcd563e6866d4d319b8b5eb1508bcf792025-03-02T11:42:25Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202008-10-010514201401Adhesion molecules and cell-cytokine complex in vascular remodeling among patients with arterial hypertension and metabolic risk factorsL. R. Iskandarova0E. G. Mutalova1E. R. Smakaeva2L. N. Mingazetdinova3G. M. Sakhautdinova4Башкирский государственный медицинский университет, УфаБашкирский государственный медицинский университет, УфаБашкирский государственный медицинский университет, УфаБашкирский государственный медицинский университет, УфаБашкирский государственный медицинский университет, УфаThe interaction between intercellular adhesion molecules, pro-inflammatory cytokines as apoptosis agents, and lymphocyte receptors was studied in patients with arterial hypertension (AH) and metabolic disturbances. The study involved 85 AH patients: Group I (AH and obesity, O), Group II (AH, O, and insulin resistance, IR), Group III (AH only). Integral leukocyte indices, intercellular and vascular wall adhesion molecules (ICAM-2, VCAM-1, p-selectin), lymphocyte receptors (CD16, CD25, CD95), pro-inflammatory cytokines (IL-в, IF-г, TNF-б), carbohydrate and lipid metabolism parameters were studied. Increased expression of soluble adhesion molecules sVCAM-1 and sp-selectin was observed in all AH patients, especially in Group II. Decreased levels of apoptosis initiators, CD16+(NK) and CD25+ lymphocytes with high expression of Fas-receptors (CD95) which activate neutrophil apoptosis, were observed, as well as a 2-5-fold increase in TNF concentration - a key factor in inflammation and apoptosis induction. Massive cell death and lipid accumulation is one of the main morphologic characteristics of atherosclerotic plaque, highly prevalent in patients with AH, O, and IR. Intercellular adhesion molecule expression could be regarded as endothelial cell apoptosis predictor.https://russjcardiol.elpub.ru/jour/article/view/1619arterial hypertensionobesityinsulin resistanceintercellular adhesion moleculeslymphocyte receptorscytokines |
| spellingShingle | L. R. Iskandarova E. G. Mutalova E. R. Smakaeva L. N. Mingazetdinova G. M. Sakhautdinova Adhesion molecules and cell-cytokine complex in vascular remodeling among patients with arterial hypertension and metabolic risk factors Российский кардиологический журнал arterial hypertension obesity insulin resistance intercellular adhesion molecules lymphocyte receptors cytokines |
| title | Adhesion molecules and cell-cytokine complex in vascular remodeling among patients with arterial hypertension and metabolic risk factors |
| title_full | Adhesion molecules and cell-cytokine complex in vascular remodeling among patients with arterial hypertension and metabolic risk factors |
| title_fullStr | Adhesion molecules and cell-cytokine complex in vascular remodeling among patients with arterial hypertension and metabolic risk factors |
| title_full_unstemmed | Adhesion molecules and cell-cytokine complex in vascular remodeling among patients with arterial hypertension and metabolic risk factors |
| title_short | Adhesion molecules and cell-cytokine complex in vascular remodeling among patients with arterial hypertension and metabolic risk factors |
| title_sort | adhesion molecules and cell cytokine complex in vascular remodeling among patients with arterial hypertension and metabolic risk factors |
| topic | arterial hypertension obesity insulin resistance intercellular adhesion molecules lymphocyte receptors cytokines |
| url | https://russjcardiol.elpub.ru/jour/article/view/1619 |
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