Standardized construction of a porcine model for acute obstructive jaundice and training of endoscopic ultrasound-guided choledochoduodenostomy
BackgroundEndoscopic ultrasound-guided biliary drainage (EUS-BD) is an alternative to endoscopic retrograde cholangiopancreatography (ERCP) for patients with obstructive jaundice. However, it is still a challenge for many endoscopists because of its novelty and complexity. This study aimed to establ...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1247763/full |
| _version_ | 1797490442854465536 |
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| author | Xue Zhou Ziming Liu Wenzhuang Ma Shiyun Sheng Siyu Sun Nan Ge |
| author_facet | Xue Zhou Ziming Liu Wenzhuang Ma Shiyun Sheng Siyu Sun Nan Ge |
| author_sort | Xue Zhou |
| collection | DOAJ |
| description | BackgroundEndoscopic ultrasound-guided biliary drainage (EUS-BD) is an alternative to endoscopic retrograde cholangiopancreatography (ERCP) for patients with obstructive jaundice. However, it is still a challenge for many endoscopists because of its novelty and complexity. This study aimed to establish an ideal bile duct dilatation model for the training and practice of endoscopic ultrasound-guided choledochoduodenostomy (EUS-CDS).MethodsThe 34 healthy Bama miniature pigs were divided into the part of developing the standardized EUS-CDS (n=9) and the part of trainees training (n=25). Part one, two different methods were used to clip Vater’s ampulla using metal clips to establish an extrahepatic bile duct dilatation model. Part two, five trainees were trained on EUS-CDS with 25 pigs. Following a 2-week observation period, the feasibility and effectiveness of the technique were evaluated.ResultsIn the group with three metal clips perpendicular to the duodenal wall clipping Vater’s ampulla, the success rate of extrahepatic bile duct dilation greater than 1 cm in 24 h was 5/6, whereas the remaining one pig was 48 h. All five trainees can finally complete the EUS-CDS independently. No death occurred during the 2-week observation period.ConclusionClipping Vater’s ampulla with three metal clips perpendicular to the duodenal wall is an effective and stable method to create a porcine bile duct dilatation model. |
| first_indexed | 2024-03-10T00:33:03Z |
| format | Article |
| id | doaj.art-fcd6fb24e43d49d880a29a7802242ad1 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-10T00:33:03Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-fcd6fb24e43d49d880a29a7802242ad12023-11-23T15:23:04ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-11-011310.3389/fonc.2023.12477631247763Standardized construction of a porcine model for acute obstructive jaundice and training of endoscopic ultrasound-guided choledochoduodenostomyXue ZhouZiming LiuWenzhuang MaShiyun ShengSiyu SunNan GeBackgroundEndoscopic ultrasound-guided biliary drainage (EUS-BD) is an alternative to endoscopic retrograde cholangiopancreatography (ERCP) for patients with obstructive jaundice. However, it is still a challenge for many endoscopists because of its novelty and complexity. This study aimed to establish an ideal bile duct dilatation model for the training and practice of endoscopic ultrasound-guided choledochoduodenostomy (EUS-CDS).MethodsThe 34 healthy Bama miniature pigs were divided into the part of developing the standardized EUS-CDS (n=9) and the part of trainees training (n=25). Part one, two different methods were used to clip Vater’s ampulla using metal clips to establish an extrahepatic bile duct dilatation model. Part two, five trainees were trained on EUS-CDS with 25 pigs. Following a 2-week observation period, the feasibility and effectiveness of the technique were evaluated.ResultsIn the group with three metal clips perpendicular to the duodenal wall clipping Vater’s ampulla, the success rate of extrahepatic bile duct dilation greater than 1 cm in 24 h was 5/6, whereas the remaining one pig was 48 h. All five trainees can finally complete the EUS-CDS independently. No death occurred during the 2-week observation period.ConclusionClipping Vater’s ampulla with three metal clips perpendicular to the duodenal wall is an effective and stable method to create a porcine bile duct dilatation model.https://www.frontiersin.org/articles/10.3389/fonc.2023.1247763/fullbiliary drainageendoscopic ultrasound-guided choledochoduodenostomycommon bile ductporcine modelstent |
| spellingShingle | Xue Zhou Ziming Liu Wenzhuang Ma Shiyun Sheng Siyu Sun Nan Ge Standardized construction of a porcine model for acute obstructive jaundice and training of endoscopic ultrasound-guided choledochoduodenostomy Frontiers in Oncology biliary drainage endoscopic ultrasound-guided choledochoduodenostomy common bile duct porcine model stent |
| title | Standardized construction of a porcine model for acute obstructive jaundice and training of endoscopic ultrasound-guided choledochoduodenostomy |
| title_full | Standardized construction of a porcine model for acute obstructive jaundice and training of endoscopic ultrasound-guided choledochoduodenostomy |
| title_fullStr | Standardized construction of a porcine model for acute obstructive jaundice and training of endoscopic ultrasound-guided choledochoduodenostomy |
| title_full_unstemmed | Standardized construction of a porcine model for acute obstructive jaundice and training of endoscopic ultrasound-guided choledochoduodenostomy |
| title_short | Standardized construction of a porcine model for acute obstructive jaundice and training of endoscopic ultrasound-guided choledochoduodenostomy |
| title_sort | standardized construction of a porcine model for acute obstructive jaundice and training of endoscopic ultrasound guided choledochoduodenostomy |
| topic | biliary drainage endoscopic ultrasound-guided choledochoduodenostomy common bile duct porcine model stent |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1247763/full |
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