Diagnostic Accuracy of Fine Needle Aspiration Cytology in Breast Masses among Children and Adolescents Aged Below 21 Years - A Cross-sectional Study
Introduction: Breast diseases in paediatric and adolescence are unusual. Fine Needle Aspiration Cytology (FNAC) has an important role in triaging breast masses, more so in younger population, wherein preoperative accurate diagnosis has significant impact on selecting and planning treatment. Role...
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JCDR Research and Publications Private Limited
2021-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/15116/46932_CE[Ra1]_F[SK]_PF1(AG_OM)_PFA(KM)_PB(AG_KM)_PN(KM).pdf |
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| author | T Rajini K Amita |
| author_facet | T Rajini K Amita |
| author_sort | T Rajini |
| collection | DOAJ |
| description | Introduction: Breast diseases in paediatric and adolescence
are unusual. Fine Needle Aspiration Cytology (FNAC) has an
important role in triaging breast masses, more so in younger
population, wherein preoperative accurate diagnosis has
significant impact on selecting and planning treatment. Role of
FNAC in breast lesions amongst children and adolescents has
not been explored much.
Aim: To study the role of FNAC in diagnosis of breast lesions in
children and adolescents.
Materials and Methods: A cross-sectional study was
conducted between June 2017 to May 2019 at Adichunchanagiri
Institute of Medical Sciences, Mandya, Karnataka, India. All
the patients presenting with breast lesion aged below 21
years, referred to FNAC clinic during this period were included
in the study. The diagnoses were categorised as inflammatory,
benign, atypia, suspicious and malignant. Cytohistopathology
concordance was attempted wherever possible. Analysis was
done using Statistical Package for the Social Sciences (SPSS)
software version 17.0.
Results: Out of total 45 cases, 37 (82.22%) were females
and 8 (17.78%) were males. Breast lesions in paediatric and
adolescents accounted for 15.20% (45/296) of total breast
FNAC performed during the study period. The morphologic
spectrum seen most commonly was fibroadenoma (FA)
62.22% (28/45), benign breast disease 8.88% (4/45), mastitis
4.44% (2/45). Morphologic variations observed in FA were
epithelial hyperplasia 32.14% (9/28), cystic change 28.57%
(8/28), hypercellular stoma 21.42% (6/28), multinucleate
giant cells 32.14% (9/28), apocrine change 14.28% (4/28),
adenosis 10.71% (3/28), columnar cell change 10.71% (3/28),
squamous metaplasia 3.57% (1/28) and atypia 3.57%(1/28).
Histopathologic association was obtained in 31 cases (68.88%).
Overall sensitivity, specificity, positive predictive value, negative
predictive value and diagnostic accuracy of FNAC was found to
be 50%, 100%, 100%, 96.6%, 96.77%, respectively.
Conclusion: Majority of the breast lesions in paediatric and
adolescents are benign in nature with FA being the most
common. The FNAC had high specificity and diagnostic
accuracy, thereby establishing its role in selecting appropriate
treatment for this age group of patients |
| first_indexed | 2024-12-22T10:18:46Z |
| format | Article |
| id | doaj.art-fcd7b8dd40b74fb0aab9da0d0845b528 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-22T10:18:46Z |
| publishDate | 2021-07-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-fcd7b8dd40b74fb0aab9da0d0845b5282022-12-21T18:29:41ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2021-07-011507152010.7860/JCDR/2021/46932.15116Diagnostic Accuracy of Fine Needle Aspiration Cytology in Breast Masses among Children and Adolescents Aged Below 21 Years - A Cross-sectional StudyT Rajini0K Amita1Assistant Professor, Department of Pathology, Adichunchanagiri Institute of Medical Sciences, Mandya, Karnataka, IndiaProfessor, Department of Pathology, Adichunchanagiri Institute of Medical Sciences, Mandya, Karnataka, India.Introduction: Breast diseases in paediatric and adolescence are unusual. Fine Needle Aspiration Cytology (FNAC) has an important role in triaging breast masses, more so in younger population, wherein preoperative accurate diagnosis has significant impact on selecting and planning treatment. Role of FNAC in breast lesions amongst children and adolescents has not been explored much. Aim: To study the role of FNAC in diagnosis of breast lesions in children and adolescents. Materials and Methods: A cross-sectional study was conducted between June 2017 to May 2019 at Adichunchanagiri Institute of Medical Sciences, Mandya, Karnataka, India. All the patients presenting with breast lesion aged below 21 years, referred to FNAC clinic during this period were included in the study. The diagnoses were categorised as inflammatory, benign, atypia, suspicious and malignant. Cytohistopathology concordance was attempted wherever possible. Analysis was done using Statistical Package for the Social Sciences (SPSS) software version 17.0. Results: Out of total 45 cases, 37 (82.22%) were females and 8 (17.78%) were males. Breast lesions in paediatric and adolescents accounted for 15.20% (45/296) of total breast FNAC performed during the study period. The morphologic spectrum seen most commonly was fibroadenoma (FA) 62.22% (28/45), benign breast disease 8.88% (4/45), mastitis 4.44% (2/45). Morphologic variations observed in FA were epithelial hyperplasia 32.14% (9/28), cystic change 28.57% (8/28), hypercellular stoma 21.42% (6/28), multinucleate giant cells 32.14% (9/28), apocrine change 14.28% (4/28), adenosis 10.71% (3/28), columnar cell change 10.71% (3/28), squamous metaplasia 3.57% (1/28) and atypia 3.57%(1/28). Histopathologic association was obtained in 31 cases (68.88%). Overall sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of FNAC was found to be 50%, 100%, 100%, 96.6%, 96.77%, respectively. Conclusion: Majority of the breast lesions in paediatric and adolescents are benign in nature with FA being the most common. The FNAC had high specificity and diagnostic accuracy, thereby establishing its role in selecting appropriate treatment for this age group of patientshttps://jcdr.net/articles/PDF/15116/46932_CE[Ra1]_F[SK]_PF1(AG_OM)_PFA(KM)_PB(AG_KM)_PN(KM).pdfbreast neoplasmscytologypaediatric |
| spellingShingle | T Rajini K Amita Diagnostic Accuracy of Fine Needle Aspiration Cytology in Breast Masses among Children and Adolescents Aged Below 21 Years - A Cross-sectional Study Journal of Clinical and Diagnostic Research breast neoplasms cytology paediatric |
| title | Diagnostic Accuracy of Fine Needle Aspiration Cytology in Breast Masses among Children and Adolescents Aged Below 21 Years - A Cross-sectional Study |
| title_full | Diagnostic Accuracy of Fine Needle Aspiration Cytology in Breast Masses among Children and Adolescents Aged Below 21 Years - A Cross-sectional Study |
| title_fullStr | Diagnostic Accuracy of Fine Needle Aspiration Cytology in Breast Masses among Children and Adolescents Aged Below 21 Years - A Cross-sectional Study |
| title_full_unstemmed | Diagnostic Accuracy of Fine Needle Aspiration Cytology in Breast Masses among Children and Adolescents Aged Below 21 Years - A Cross-sectional Study |
| title_short | Diagnostic Accuracy of Fine Needle Aspiration Cytology in Breast Masses among Children and Adolescents Aged Below 21 Years - A Cross-sectional Study |
| title_sort | diagnostic accuracy of fine needle aspiration cytology in breast masses among children and adolescents aged below 21 years a cross sectional study |
| topic | breast neoplasms cytology paediatric |
| url | https://jcdr.net/articles/PDF/15116/46932_CE[Ra1]_F[SK]_PF1(AG_OM)_PFA(KM)_PB(AG_KM)_PN(KM).pdf |
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