Trem2 deficiency impairs recovery and phagocytosis and dysregulates myeloid gene expression during virus-induced demyelination

Trem2 deficiency impairs recovery and phagocytosis and dysregulates myeloid gene expression during virus-induced demyelination

Abstract Background Triggering receptor expressed on myeloid cells 2 (Trem2) plays a protective role in neurodegenerative diseases. By contrast, Trem2 functions can exacerbate tissue damage during respiratory viral or liver infections. We, therefore, investigated the role of Trem2 in a viral encepha...

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Bibliographic Details
Main Authors: Mihyun Hwang, Carine Savarin, Jihye Kim, Jennifer Powers, Natasha Towne, Hyunsuk Oh, Cornelia C. Bergmann
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Journal of Neuroinflammation
Subjects:
TREM2
CNS
Virus
Demyelination
Microglia
BMDM
Online Access:https://doi.org/10.1186/s12974-022-02629-1

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