Trem2 deficiency impairs recovery and phagocytosis and dysregulates myeloid gene expression during virus-induced demyelination
Abstract Background Triggering receptor expressed on myeloid cells 2 (Trem2) plays a protective role in neurodegenerative diseases. By contrast, Trem2 functions can exacerbate tissue damage during respiratory viral or liver infections. We, therefore, investigated the role of Trem2 in a viral encepha...
Main Authors: | Mihyun Hwang, Carine Savarin, Jihye Kim, Jennifer Powers, Natasha Towne, Hyunsuk Oh, Cornelia C. Bergmann |
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Format: | Article |
Language: | English |
Published: |
BMC
2022-11-01
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Series: | Journal of Neuroinflammation |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12974-022-02629-1 |
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