Feasibility of Outpatient Stem Cell Transplantation in Multiple Myeloma and Risk Factors Predictive of Hospital Admission
High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) remains the standard of care for multiple myeloma (MM) patients. Although outpatient ASCT has been shown to be safe and feasible, the procedure is overall rare with most patients in the US undergoing inpatient ASCT. Furth...
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MDPI AG
2022-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/6/1640 |
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| author | Kristin Larsen Horace Spencer Meera Mohan Clyde Bailey Kerri Hill Mathew Kottarathara Richa Parikh Shadiqul Hoque Amani Erra Angel A. Mitma Pankaj Mathur Lakshmi Yarlagadda Sravani Gundarlapalli Yetunde Ogunsesan Munawwar Hussain Nishanth Thalambedu Jaskirat Sethi Samer Al Hadidi Sharmilan Thanendrarajan Monica Graziutti Maurizio Zangari Bart Barlogie Frits van Rhee Guido Tricot Carolina Schinke |
| author_facet | Kristin Larsen Horace Spencer Meera Mohan Clyde Bailey Kerri Hill Mathew Kottarathara Richa Parikh Shadiqul Hoque Amani Erra Angel A. Mitma Pankaj Mathur Lakshmi Yarlagadda Sravani Gundarlapalli Yetunde Ogunsesan Munawwar Hussain Nishanth Thalambedu Jaskirat Sethi Samer Al Hadidi Sharmilan Thanendrarajan Monica Graziutti Maurizio Zangari Bart Barlogie Frits van Rhee Guido Tricot Carolina Schinke |
| author_sort | Kristin Larsen |
| collection | DOAJ |
| description | High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) remains the standard of care for multiple myeloma (MM) patients. Although outpatient ASCT has been shown to be safe and feasible, the procedure is overall rare with most patients in the US undergoing inpatient ASCT. Furthermore, hospitalization rates for patients that undergo outpatient ASCT remain high. Adequate markers that predict hospitalization during outpatient ASCT are lacking, yet would be of great clinical value to select patients that are suited to outpatient ASCT. In this study we aimed to elucidate differences between planned outpatient and inpatient ASCT and further evaluated clinical characteristics that are significantly associated with hospitalization during planned outpatient hospitalization. Factors that were significantly associated with a planned inpatient ASCT included an advanced MM disease stage, worse performance status as well as non-Caucasian race, while low albumin levels and female gender were significantly associated with hospitalization during outpatient ASCT. The results of this analysis provide crucial knowledge of factors that are associated with planned inpatient ASCT and hospitalization during outpatient ASCT and could guide the treating physician in decision-making and further facilitate outpatient transplantation. |
| first_indexed | 2024-03-09T19:38:04Z |
| format | Article |
| id | doaj.art-fcd97a41985f4f8fbe151f0de213b088 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T19:38:04Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-fcd97a41985f4f8fbe151f0de213b0882023-11-24T01:49:53ZengMDPI AGJournal of Clinical Medicine2077-03832022-03-01116164010.3390/jcm11061640Feasibility of Outpatient Stem Cell Transplantation in Multiple Myeloma and Risk Factors Predictive of Hospital AdmissionKristin Larsen0Horace Spencer1Meera Mohan2Clyde Bailey3Kerri Hill4Mathew Kottarathara5Richa Parikh6Shadiqul Hoque7Amani Erra8Angel A. Mitma9Pankaj Mathur10Lakshmi Yarlagadda11Sravani Gundarlapalli12Yetunde Ogunsesan13Munawwar Hussain14Nishanth Thalambedu15Jaskirat Sethi16Samer Al Hadidi17Sharmilan Thanendrarajan18Monica Graziutti19Maurizio Zangari20Bart Barlogie21Frits van Rhee22Guido Tricot23Carolina Schinke24Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USADepartment of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAMedical College of Wisconsin Cancer Center, Froedtert Hospital, Milwaukee, WI 53226, USAMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAHigh-dose chemotherapy followed by autologous stem cell transplantation (ASCT) remains the standard of care for multiple myeloma (MM) patients. Although outpatient ASCT has been shown to be safe and feasible, the procedure is overall rare with most patients in the US undergoing inpatient ASCT. Furthermore, hospitalization rates for patients that undergo outpatient ASCT remain high. Adequate markers that predict hospitalization during outpatient ASCT are lacking, yet would be of great clinical value to select patients that are suited to outpatient ASCT. In this study we aimed to elucidate differences between planned outpatient and inpatient ASCT and further evaluated clinical characteristics that are significantly associated with hospitalization during planned outpatient hospitalization. Factors that were significantly associated with a planned inpatient ASCT included an advanced MM disease stage, worse performance status as well as non-Caucasian race, while low albumin levels and female gender were significantly associated with hospitalization during outpatient ASCT. The results of this analysis provide crucial knowledge of factors that are associated with planned inpatient ASCT and hospitalization during outpatient ASCT and could guide the treating physician in decision-making and further facilitate outpatient transplantation.https://www.mdpi.com/2077-0383/11/6/1640multiple myelomaautologous stem cell transplantationhospitalization |
| spellingShingle | Kristin Larsen Horace Spencer Meera Mohan Clyde Bailey Kerri Hill Mathew Kottarathara Richa Parikh Shadiqul Hoque Amani Erra Angel A. Mitma Pankaj Mathur Lakshmi Yarlagadda Sravani Gundarlapalli Yetunde Ogunsesan Munawwar Hussain Nishanth Thalambedu Jaskirat Sethi Samer Al Hadidi Sharmilan Thanendrarajan Monica Graziutti Maurizio Zangari Bart Barlogie Frits van Rhee Guido Tricot Carolina Schinke Feasibility of Outpatient Stem Cell Transplantation in Multiple Myeloma and Risk Factors Predictive of Hospital Admission Journal of Clinical Medicine multiple myeloma autologous stem cell transplantation hospitalization |
| title | Feasibility of Outpatient Stem Cell Transplantation in Multiple Myeloma and Risk Factors Predictive of Hospital Admission |
| title_full | Feasibility of Outpatient Stem Cell Transplantation in Multiple Myeloma and Risk Factors Predictive of Hospital Admission |
| title_fullStr | Feasibility of Outpatient Stem Cell Transplantation in Multiple Myeloma and Risk Factors Predictive of Hospital Admission |
| title_full_unstemmed | Feasibility of Outpatient Stem Cell Transplantation in Multiple Myeloma and Risk Factors Predictive of Hospital Admission |
| title_short | Feasibility of Outpatient Stem Cell Transplantation in Multiple Myeloma and Risk Factors Predictive of Hospital Admission |
| title_sort | feasibility of outpatient stem cell transplantation in multiple myeloma and risk factors predictive of hospital admission |
| topic | multiple myeloma autologous stem cell transplantation hospitalization |
| url | https://www.mdpi.com/2077-0383/11/6/1640 |
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