Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation
The coronavirus disease, 2019 (COVID-19), has spread rapidly around the world and become a major public health problem facing the world. Traditional Chinese medicine (TCM) has been fully committed to treat COVID-19 in China. It improved the clinical symptoms of patients and reduced the mortality rat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.583279/full |
| _version_ | 1818646103079256064 |
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| author | Le-Le Ma Hui-Min Liu Chuan-Hong Luo Ya-Nan He Fang Wang Hao-Zhou Huang Li Han Ming Yang Run-Chun Xu Ding-Kun Zhang |
| author_facet | Le-Le Ma Hui-Min Liu Chuan-Hong Luo Ya-Nan He Fang Wang Hao-Zhou Huang Li Han Ming Yang Run-Chun Xu Ding-Kun Zhang |
| author_sort | Le-Le Ma |
| collection | DOAJ |
| description | The coronavirus disease, 2019 (COVID-19), has spread rapidly around the world and become a major public health problem facing the world. Traditional Chinese medicine (TCM) has been fully committed to treat COVID-19 in China. It improved the clinical symptoms of patients and reduced the mortality rate. In light of the fever was identified as one of leading clinical features of COVID-19, this paper will first analyze the material basis of fever, including pyrogenic cytokines and a variety of the mediators of fever. Then the humoral and neural pathways of fever signal transmission will be described. The scattered evidences about fever recorded in recent years are connected in series. On this basis, the understanding of fever is further deepened from the aspects of pathology and physiology. Finally, combining with the chemical composition and pharmacological action of available TCM, we analyzed the mechanisms of TCMs to play the antipyretic effect through multiple ways. So as to further provide the basis for the research of antipyretic compound preparations of TCMs and explore the potential medicines for the prevention and treatment of COVID-19. |
| first_indexed | 2024-12-17T00:41:19Z |
| format | Article |
| id | doaj.art-fcd9e95457f54ccc9a560d9227495aaf |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-17T00:41:19Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-fcd9e95457f54ccc9a560d9227495aaf2022-12-21T22:10:02ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-03-011210.3389/fphar.2021.583279583279Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway RegulationLe-Le Ma0Hui-Min Liu1Chuan-Hong Luo2Ya-Nan He3Fang Wang4Hao-Zhou Huang5Li Han6Ming Yang7Run-Chun Xu8Ding-Kun Zhang9State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, PR ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, PR ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, PR ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, PR ChinaState key Laboratory of Innovation Medicine and High Efficiency and Energy Saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine, Nanchang, PR ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, PR ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, PR ChinaState key Laboratory of Innovation Medicine and High Efficiency and Energy Saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine, Nanchang, PR ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, PR ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, PR ChinaThe coronavirus disease, 2019 (COVID-19), has spread rapidly around the world and become a major public health problem facing the world. Traditional Chinese medicine (TCM) has been fully committed to treat COVID-19 in China. It improved the clinical symptoms of patients and reduced the mortality rate. In light of the fever was identified as one of leading clinical features of COVID-19, this paper will first analyze the material basis of fever, including pyrogenic cytokines and a variety of the mediators of fever. Then the humoral and neural pathways of fever signal transmission will be described. The scattered evidences about fever recorded in recent years are connected in series. On this basis, the understanding of fever is further deepened from the aspects of pathology and physiology. Finally, combining with the chemical composition and pharmacological action of available TCM, we analyzed the mechanisms of TCMs to play the antipyretic effect through multiple ways. So as to further provide the basis for the research of antipyretic compound preparations of TCMs and explore the potential medicines for the prevention and treatment of COVID-19.https://www.frontiersin.org/articles/10.3389/fphar.2021.583279/fullCOVID-19feverantipyretictraditional chinese medicinemechanismbioactive components |
| spellingShingle | Le-Le Ma Hui-Min Liu Chuan-Hong Luo Ya-Nan He Fang Wang Hao-Zhou Huang Li Han Ming Yang Run-Chun Xu Ding-Kun Zhang Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation Frontiers in Pharmacology COVID-19 fever antipyretic traditional chinese medicine mechanism bioactive components |
| title | Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation |
| title_full | Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation |
| title_fullStr | Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation |
| title_full_unstemmed | Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation |
| title_short | Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation |
| title_sort | fever and antipyretic supported by traditional chinese medicine a multi pathway regulation |
| topic | COVID-19 fever antipyretic traditional chinese medicine mechanism bioactive components |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.583279/full |
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