The Role of Properdin in Killing of Non-Pathogenic Leptospira biflexa

The Role of Properdin in Killing of Non-Pathogenic Leptospira biflexa

Properdin (P) is a positive regulatory protein that stabilizes the C3 convertase and C5 convertase of the complement alternative pathway (AP). Several studies have suggested that properdin can bind directly to the surface of certain pathogens regardless of the presence of C3bBb. Saprophytic Leptospi...

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Bibliographic Details
Main Authors: Adriana Patricia Granados Martinez, Patrícia Antonia Estima Abreu, Silvio de Arruda Vasconcellos, Paulo Lee Ho, Viviana P. Ferreira, Gurpanna Saggu, Angela Silva Barbosa, Lourdes Isaac
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
properdin
Leptospira
complement system
alternative pathway
bacteria killing ability
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.572562/full

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