PET Radiotracers for CNS-Adrenergic Receptors: Developments and Perspectives
Epinephrine (E) and norepinephrine (NE) play diverse roles in our body’s physiology. In addition to their role in the peripheral nervous system (PNS), E/NE systems including their receptors are critical to the central nervous system (CNS) and to mental health. Various antipsychotics, antidepressants...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/17/4017 |
| _version_ | 1797554811516747776 |
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| author | Santosh Reddy Alluri Sung Won Kim Nora D. Volkow Kun-Eek Kil |
| author_facet | Santosh Reddy Alluri Sung Won Kim Nora D. Volkow Kun-Eek Kil |
| author_sort | Santosh Reddy Alluri |
| collection | DOAJ |
| description | Epinephrine (E) and norepinephrine (NE) play diverse roles in our body’s physiology. In addition to their role in the peripheral nervous system (PNS), E/NE systems including their receptors are critical to the central nervous system (CNS) and to mental health. Various antipsychotics, antidepressants, and psychostimulants exert their influence partially through different subtypes of adrenergic receptors (ARs). Despite the potential of pharmacological applications and long history of research related to E/NE systems, research efforts to identify the roles of ARs in the human brain taking advantage of imaging have been limited by the lack of subtype specific ligands for ARs and brain penetrability issues. This review provides an overview of the development of positron emission tomography (PET) radiotracers for in vivo imaging of AR system in the brain. |
| first_indexed | 2024-03-10T16:37:23Z |
| format | Article |
| id | doaj.art-fcda3967d0404e87b63e04888192b4a0 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T16:37:23Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-fcda3967d0404e87b63e04888192b4a02023-11-20T12:23:28ZengMDPI AGMolecules1420-30492020-09-012517401710.3390/molecules25174017PET Radiotracers for CNS-Adrenergic Receptors: Developments and PerspectivesSantosh Reddy Alluri0Sung Won Kim1Nora D. Volkow2Kun-Eek Kil3University of Missouri Research Reactor, University of Missouri, Columbia, MO 65211-5110, USALaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-1013, USALaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-1013, USAUniversity of Missouri Research Reactor, University of Missouri, Columbia, MO 65211-5110, USAEpinephrine (E) and norepinephrine (NE) play diverse roles in our body’s physiology. In addition to their role in the peripheral nervous system (PNS), E/NE systems including their receptors are critical to the central nervous system (CNS) and to mental health. Various antipsychotics, antidepressants, and psychostimulants exert their influence partially through different subtypes of adrenergic receptors (ARs). Despite the potential of pharmacological applications and long history of research related to E/NE systems, research efforts to identify the roles of ARs in the human brain taking advantage of imaging have been limited by the lack of subtype specific ligands for ARs and brain penetrability issues. This review provides an overview of the development of positron emission tomography (PET) radiotracers for in vivo imaging of AR system in the brain.https://www.mdpi.com/1420-3049/25/17/4017adrenergic receptorpositron emission tomographyradiotracer |
| spellingShingle | Santosh Reddy Alluri Sung Won Kim Nora D. Volkow Kun-Eek Kil PET Radiotracers for CNS-Adrenergic Receptors: Developments and Perspectives Molecules adrenergic receptor positron emission tomography radiotracer |
| title | PET Radiotracers for CNS-Adrenergic Receptors: Developments and Perspectives |
| title_full | PET Radiotracers for CNS-Adrenergic Receptors: Developments and Perspectives |
| title_fullStr | PET Radiotracers for CNS-Adrenergic Receptors: Developments and Perspectives |
| title_full_unstemmed | PET Radiotracers for CNS-Adrenergic Receptors: Developments and Perspectives |
| title_short | PET Radiotracers for CNS-Adrenergic Receptors: Developments and Perspectives |
| title_sort | pet radiotracers for cns adrenergic receptors developments and perspectives |
| topic | adrenergic receptor positron emission tomography radiotracer |
| url | https://www.mdpi.com/1420-3049/25/17/4017 |
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