HuR Plays a Role in Double-Strand Break Repair in Pancreatic Cancer Cells and Regulates Functional BRCA1-Associated-Ring-Domain-1(BARD1) Isoforms

HuR Plays a Role in Double-Strand Break Repair in Pancreatic Cancer Cells and Regulates Functional BRCA1-Associated-Ring-Domain-1(BARD1) Isoforms

Human Antigen R (HuR/ELAVL1) is known to regulate stability of mRNAs involved in pancreatic ductal adenocarcinoma (PDAC) cell survival. Although several HuR targets are established, it is likely that many remain currently unknown. Here, we identified BARD1 mRNA as a novel target of HuR. Silencing Hu...

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Bibliographic Details
Main Authors: Aditi Jain, Matthew McCoy, Carolyn Coats, Samantha Z. Brown, Sankar Addya, Carl Pelz, Rosalie C. Sears, Charles J. Yeo, Jonathan R. Brody
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cancers
Subjects:
pancreatic ductal adenocarcinoma
BARD1
HuR
RNA binding protein
DNA repair
Online Access:https://www.mdpi.com/2072-6694/14/7/1848

Internet

https://www.mdpi.com/2072-6694/14/7/1848

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