Factor V Leiden, Factor II, Protein C, Protein S, and Antithrombin and Ischemic Strokes in Young Adults: A Meta-Analysis
Ischemic strokes are one of the leading causes of death worldwide. The aim of this meta-analysis is to elaborate on the role of inherited predisposition to thrombophilia in the etiology of ischemic strokes in young adults. The keywords factor V Leiden (FVL), factor II, prothrombin (PT), protein C (P...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/11/2081 |
| _version_ | 1797468192956743680 |
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| author | Mihael Tsalta-Mladenov Mariya Levkova Silva Andonova |
| author_facet | Mihael Tsalta-Mladenov Mariya Levkova Silva Andonova |
| author_sort | Mihael Tsalta-Mladenov |
| collection | DOAJ |
| description | Ischemic strokes are one of the leading causes of death worldwide. The aim of this meta-analysis is to elaborate on the role of inherited predisposition to thrombophilia in the etiology of ischemic strokes in young adults. The keywords factor V Leiden (FVL), factor II, prothrombin (PT), protein C (PC), protein S (PS), antithrombin (AT), ischemic stroke, and young were used to search different databases. We selected studies with participants who were between 18 and 65 years. A total of 104 studies were eligible for inclusion in the meta-analysis. All the studied genetic markers were risk factors for ischemic stroke according to our results (FVL OR = 1.74; PT OR = 1.95; PC OR = 10.20; PS OR = 1.74; AT OR = 3.47; <i>p</i> < 0.05). There was moderate heterogeneity for most of the results, and subgroup analyses were conducted by dividing the studies according to the geographic location, gender ratio, and selection criteria of the performed study. There were no significant differences between the groups, but different geographic location was a probable source of heterogeneity. All of the studied markers—FVL, prothrombin, PC, PS, and AT—were significantly associated with increased risk of ischemic stroke in young adults and, if tested, could improve the quality of care. |
| first_indexed | 2024-03-09T19:04:04Z |
| format | Article |
| id | doaj.art-fcdb4f258e674dc487d3a86b035c6278 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T19:04:04Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-fcdb4f258e674dc487d3a86b035c62782023-11-24T04:49:27ZengMDPI AGGenes2073-44252022-11-011311208110.3390/genes13112081Factor V Leiden, Factor II, Protein C, Protein S, and Antithrombin and Ischemic Strokes in Young Adults: A Meta-AnalysisMihael Tsalta-Mladenov0Mariya Levkova1Silva Andonova2Department of Neurology and Neuroscience, Medical University “Prof. Paraskev Stoyanov”, Marin Drinov St. 55, 9000 Varna, BulgariaDepartment of Medical Genetics, Medical University “Prof. Paraskev Stoyanov”, Marin Drinov St. 55, 9000 Varna, BulgariaDepartment of Neurology and Neuroscience, Medical University “Prof. Paraskev Stoyanov”, Marin Drinov St. 55, 9000 Varna, BulgariaIschemic strokes are one of the leading causes of death worldwide. The aim of this meta-analysis is to elaborate on the role of inherited predisposition to thrombophilia in the etiology of ischemic strokes in young adults. The keywords factor V Leiden (FVL), factor II, prothrombin (PT), protein C (PC), protein S (PS), antithrombin (AT), ischemic stroke, and young were used to search different databases. We selected studies with participants who were between 18 and 65 years. A total of 104 studies were eligible for inclusion in the meta-analysis. All the studied genetic markers were risk factors for ischemic stroke according to our results (FVL OR = 1.74; PT OR = 1.95; PC OR = 10.20; PS OR = 1.74; AT OR = 3.47; <i>p</i> < 0.05). There was moderate heterogeneity for most of the results, and subgroup analyses were conducted by dividing the studies according to the geographic location, gender ratio, and selection criteria of the performed study. There were no significant differences between the groups, but different geographic location was a probable source of heterogeneity. All of the studied markers—FVL, prothrombin, PC, PS, and AT—were significantly associated with increased risk of ischemic stroke in young adults and, if tested, could improve the quality of care.https://www.mdpi.com/2073-4425/13/11/2081strokeyoungthrombophiliafactor V Leidenprothrombinprotein C |
| spellingShingle | Mihael Tsalta-Mladenov Mariya Levkova Silva Andonova Factor V Leiden, Factor II, Protein C, Protein S, and Antithrombin and Ischemic Strokes in Young Adults: A Meta-Analysis Genes stroke young thrombophilia factor V Leiden prothrombin protein C |
| title | Factor V Leiden, Factor II, Protein C, Protein S, and Antithrombin and Ischemic Strokes in Young Adults: A Meta-Analysis |
| title_full | Factor V Leiden, Factor II, Protein C, Protein S, and Antithrombin and Ischemic Strokes in Young Adults: A Meta-Analysis |
| title_fullStr | Factor V Leiden, Factor II, Protein C, Protein S, and Antithrombin and Ischemic Strokes in Young Adults: A Meta-Analysis |
| title_full_unstemmed | Factor V Leiden, Factor II, Protein C, Protein S, and Antithrombin and Ischemic Strokes in Young Adults: A Meta-Analysis |
| title_short | Factor V Leiden, Factor II, Protein C, Protein S, and Antithrombin and Ischemic Strokes in Young Adults: A Meta-Analysis |
| title_sort | factor v leiden factor ii protein c protein s and antithrombin and ischemic strokes in young adults a meta analysis |
| topic | stroke young thrombophilia factor V Leiden prothrombin protein C |
| url | https://www.mdpi.com/2073-4425/13/11/2081 |
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