Impact of dehydroepiandrosterone (DHEA) supplementation on testosterone concentrations and BMI in elderly women: A meta-analysis of randomized controlled trials
Background: Despite the fact that numerous clinical studies have evaluated the positive effects of dehydroepiandrosterone (DHEA) supplementation on testosterone concentrations and on the body mass index (BMI), more evidence is needed to certify that DHEA is a BMI-reducing agent in the elderly. This...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Complementary Therapies in Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0965229920318872 |
| _version_ | 1818645109099462656 |
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| author | Ying Hu Ping Wan Xiaoqing An Guilin Jiang |
| author_facet | Ying Hu Ping Wan Xiaoqing An Guilin Jiang |
| author_sort | Ying Hu |
| collection | DOAJ |
| description | Background: Despite the fact that numerous clinical studies have evaluated the positive effects of dehydroepiandrosterone (DHEA) supplementation on testosterone concentrations and on the body mass index (BMI), more evidence is needed to certify that DHEA is a BMI-reducing agent in the elderly. This meta-analysis aims to clarify the various incompatible results and investigate the impact of DHEA supplementation on serum testosterone levels and lean body mass in elderly women. Methods: Four scientific databases (EMBASE, PubMed/MEDLINE, Scopus and Web of Science) were searched from inception until 20 August 2020 for trials comparing DHEA with placebo. Results were presented as weighted mean differences (WMDs) and 95 % confidence intervals (CIs) based on the random effects model (DerSimonian-Laird approach). Results: Nine arms with 793 subjects reported testosterone as an outcome measure. The overall results demonstrated that testosterone levels increased significantly after DHEA administration in elderly women (WMD: 17.52 ng/dL, 95 % CI: 6.61, 28.43, P = 0.002). In addition, DHEA administration significantly decreased the BMI (WMD:-0.39 kg/m2, I2 = 0.0 %). Conclusion: The results of the current meta-analysis support the use of DHEA supplementation for increasing testosterone concentrations in elderly women. |
| first_indexed | 2024-12-17T00:25:31Z |
| format | Article |
| id | doaj.art-fcdc736d8f764316a21bbba74de2818c |
| institution | Directory Open Access Journal |
| issn | 0965-2299 |
| language | English |
| last_indexed | 2024-12-17T00:25:31Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Complementary Therapies in Medicine |
| spelling | doaj.art-fcdc736d8f764316a21bbba74de2818c2022-12-21T22:10:28ZengElsevierComplementary Therapies in Medicine0965-22992021-01-0156102620Impact of dehydroepiandrosterone (DHEA) supplementation on testosterone concentrations and BMI in elderly women: A meta-analysis of randomized controlled trialsYing Hu0Ping Wan1Xiaoqing An2Guilin Jiang3Department of Gynecology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Room 445, Bayi Road, Donghu District, Nanchang City, Jiangxi Province, 330006, ChinaDepartment of Gynecology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Room 445, Bayi Road, Donghu District, Nanchang City, Jiangxi Province, 330006, ChinaDepartment of Gynecology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Room 445, Bayi Road, Donghu District, Nanchang City, Jiangxi Province, 330006, ChinaCorresponding author.; Department of Gynecology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Room 445, Bayi Road, Donghu District, Nanchang City, Jiangxi Province, 330006, ChinaBackground: Despite the fact that numerous clinical studies have evaluated the positive effects of dehydroepiandrosterone (DHEA) supplementation on testosterone concentrations and on the body mass index (BMI), more evidence is needed to certify that DHEA is a BMI-reducing agent in the elderly. This meta-analysis aims to clarify the various incompatible results and investigate the impact of DHEA supplementation on serum testosterone levels and lean body mass in elderly women. Methods: Four scientific databases (EMBASE, PubMed/MEDLINE, Scopus and Web of Science) were searched from inception until 20 August 2020 for trials comparing DHEA with placebo. Results were presented as weighted mean differences (WMDs) and 95 % confidence intervals (CIs) based on the random effects model (DerSimonian-Laird approach). Results: Nine arms with 793 subjects reported testosterone as an outcome measure. The overall results demonstrated that testosterone levels increased significantly after DHEA administration in elderly women (WMD: 17.52 ng/dL, 95 % CI: 6.61, 28.43, P = 0.002). In addition, DHEA administration significantly decreased the BMI (WMD:-0.39 kg/m2, I2 = 0.0 %). Conclusion: The results of the current meta-analysis support the use of DHEA supplementation for increasing testosterone concentrations in elderly women.http://www.sciencedirect.com/science/article/pii/S0965229920318872DehydroepiandrosteroneDHEAWomenTestosteroneBMIElderly |
| spellingShingle | Ying Hu Ping Wan Xiaoqing An Guilin Jiang Impact of dehydroepiandrosterone (DHEA) supplementation on testosterone concentrations and BMI in elderly women: A meta-analysis of randomized controlled trials Complementary Therapies in Medicine Dehydroepiandrosterone DHEA Women Testosterone BMI Elderly |
| title | Impact of dehydroepiandrosterone (DHEA) supplementation on testosterone concentrations and BMI in elderly women: A meta-analysis of randomized controlled trials |
| title_full | Impact of dehydroepiandrosterone (DHEA) supplementation on testosterone concentrations and BMI in elderly women: A meta-analysis of randomized controlled trials |
| title_fullStr | Impact of dehydroepiandrosterone (DHEA) supplementation on testosterone concentrations and BMI in elderly women: A meta-analysis of randomized controlled trials |
| title_full_unstemmed | Impact of dehydroepiandrosterone (DHEA) supplementation on testosterone concentrations and BMI in elderly women: A meta-analysis of randomized controlled trials |
| title_short | Impact of dehydroepiandrosterone (DHEA) supplementation on testosterone concentrations and BMI in elderly women: A meta-analysis of randomized controlled trials |
| title_sort | impact of dehydroepiandrosterone dhea supplementation on testosterone concentrations and bmi in elderly women a meta analysis of randomized controlled trials |
| topic | Dehydroepiandrosterone DHEA Women Testosterone BMI Elderly |
| url | http://www.sciencedirect.com/science/article/pii/S0965229920318872 |
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