Polyphosphate as a Target for Interference With Inflammation and Thrombosis
Activated platelets and mast cells expose the inorganic polymer, polyphosphate (polyP) on their surfaces. PolyP initiates procoagulant and proinflammatory reactions and the polymer has been recognized as a therapeutic target for interference with blood coagulation and vascular hyperpermeability. Pol...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fmed.2019.00076/full |
| _version_ | 1818331894366863360 |
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| author | Reiner K. W. Mailer Lorena Hänel Mikel Allende Thomas Renné |
| author_facet | Reiner K. W. Mailer Lorena Hänel Mikel Allende Thomas Renné |
| author_sort | Reiner K. W. Mailer |
| collection | DOAJ |
| description | Activated platelets and mast cells expose the inorganic polymer, polyphosphate (polyP) on their surfaces. PolyP initiates procoagulant and proinflammatory reactions and the polymer has been recognized as a therapeutic target for interference with blood coagulation and vascular hyperpermeability. PolyP content and chain length depend on the specific cell type and energy status, which may affect cellular functions. PolyP metabolism has mainly been studied in bacteria and yeast, but its roles in eukaryotic cells and mammalian systems have remained enigmatic. In this review, we will present an overview of polyP functions, focusing on intra- and extracellular roles of the polymer and discuss open questions that emerge from the current knowledge on polyP regulation. |
| first_indexed | 2024-12-13T13:27:06Z |
| format | Article |
| id | doaj.art-fcdc8fcd0f5a446ba891629079638b9f |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-13T13:27:06Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-fcdc8fcd0f5a446ba891629079638b9f2022-12-21T23:44:17ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2019-04-01610.3389/fmed.2019.00076446950Polyphosphate as a Target for Interference With Inflammation and ThrombosisReiner K. W. MailerLorena HänelMikel AllendeThomas RennéActivated platelets and mast cells expose the inorganic polymer, polyphosphate (polyP) on their surfaces. PolyP initiates procoagulant and proinflammatory reactions and the polymer has been recognized as a therapeutic target for interference with blood coagulation and vascular hyperpermeability. PolyP content and chain length depend on the specific cell type and energy status, which may affect cellular functions. PolyP metabolism has mainly been studied in bacteria and yeast, but its roles in eukaryotic cells and mammalian systems have remained enigmatic. In this review, we will present an overview of polyP functions, focusing on intra- and extracellular roles of the polymer and discuss open questions that emerge from the current knowledge on polyP regulation.https://www.frontiersin.org/article/10.3389/fmed.2019.00076/fullpolyphosphatefactor XIIhereditary angioedemathrombosisinflammationcoagulation |
| spellingShingle | Reiner K. W. Mailer Lorena Hänel Mikel Allende Thomas Renné Polyphosphate as a Target for Interference With Inflammation and Thrombosis Frontiers in Medicine polyphosphate factor XII hereditary angioedema thrombosis inflammation coagulation |
| title | Polyphosphate as a Target for Interference With Inflammation and Thrombosis |
| title_full | Polyphosphate as a Target for Interference With Inflammation and Thrombosis |
| title_fullStr | Polyphosphate as a Target for Interference With Inflammation and Thrombosis |
| title_full_unstemmed | Polyphosphate as a Target for Interference With Inflammation and Thrombosis |
| title_short | Polyphosphate as a Target for Interference With Inflammation and Thrombosis |
| title_sort | polyphosphate as a target for interference with inflammation and thrombosis |
| topic | polyphosphate factor XII hereditary angioedema thrombosis inflammation coagulation |
| url | https://www.frontiersin.org/article/10.3389/fmed.2019.00076/full |
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