Targeting Glutamate Neurotoxicity through Dietary Manipulation: Potential Treatment for Migraine
Glutamate, the main excitatory neurotransmitter in the central nervous system, is implicated in both the initiation of migraine as well as central sensitization, which increases the frequency of migraine attacks. Excessive levels of glutamate can lead to excitotoxicity in the nervous system which ca...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/15/18/3952 |
| _version_ | 1797578362115325952 |
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| author | Fahimeh Martami Kathleen F. Holton |
| author_facet | Fahimeh Martami Kathleen F. Holton |
| author_sort | Fahimeh Martami |
| collection | DOAJ |
| description | Glutamate, the main excitatory neurotransmitter in the central nervous system, is implicated in both the initiation of migraine as well as central sensitization, which increases the frequency of migraine attacks. Excessive levels of glutamate can lead to excitotoxicity in the nervous system which can disrupt normal neurotransmission and contribute to neuronal injury or death. Glutamate-mediated excitotoxicity also leads to neuroinflammation, oxidative stress, blood-brain barrier permeability, and cerebral vasodilation, all of which are associated with migraine pathophysiology. Experimental evidence has shown the protective effects of several nutrients against excitotoxicity. The current review focuses on the mechanisms behind glutamate’s involvement in migraines as well as a discussion on how specific nutrients are able to work towards restoring glutamate homeostasis. Understanding glutamate’s role in migraine is of vital importance for understanding why migraine is commonly comorbid with widespread pain conditions and for informing future research directions. |
| first_indexed | 2024-03-10T22:20:52Z |
| format | Article |
| id | doaj.art-fcdcb54c92684df1a24841ae71282541 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T22:20:52Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-fcdcb54c92684df1a24841ae712825412023-11-19T12:18:12ZengMDPI AGNutrients2072-66432023-09-011518395210.3390/nu15183952Targeting Glutamate Neurotoxicity through Dietary Manipulation: Potential Treatment for MigraineFahimeh Martami0Kathleen F. Holton1Department of Health Studies, American University, Washington, DC 20016, USADepartment of Health Studies, American University, Washington, DC 20016, USAGlutamate, the main excitatory neurotransmitter in the central nervous system, is implicated in both the initiation of migraine as well as central sensitization, which increases the frequency of migraine attacks. Excessive levels of glutamate can lead to excitotoxicity in the nervous system which can disrupt normal neurotransmission and contribute to neuronal injury or death. Glutamate-mediated excitotoxicity also leads to neuroinflammation, oxidative stress, blood-brain barrier permeability, and cerebral vasodilation, all of which are associated with migraine pathophysiology. Experimental evidence has shown the protective effects of several nutrients against excitotoxicity. The current review focuses on the mechanisms behind glutamate’s involvement in migraines as well as a discussion on how specific nutrients are able to work towards restoring glutamate homeostasis. Understanding glutamate’s role in migraine is of vital importance for understanding why migraine is commonly comorbid with widespread pain conditions and for informing future research directions.https://www.mdpi.com/2072-6643/15/18/3952excitotoxicityneuroinflammationoxidative stressmigrainenutrientsdiet |
| spellingShingle | Fahimeh Martami Kathleen F. Holton Targeting Glutamate Neurotoxicity through Dietary Manipulation: Potential Treatment for Migraine Nutrients excitotoxicity neuroinflammation oxidative stress migraine nutrients diet |
| title | Targeting Glutamate Neurotoxicity through Dietary Manipulation: Potential Treatment for Migraine |
| title_full | Targeting Glutamate Neurotoxicity through Dietary Manipulation: Potential Treatment for Migraine |
| title_fullStr | Targeting Glutamate Neurotoxicity through Dietary Manipulation: Potential Treatment for Migraine |
| title_full_unstemmed | Targeting Glutamate Neurotoxicity through Dietary Manipulation: Potential Treatment for Migraine |
| title_short | Targeting Glutamate Neurotoxicity through Dietary Manipulation: Potential Treatment for Migraine |
| title_sort | targeting glutamate neurotoxicity through dietary manipulation potential treatment for migraine |
| topic | excitotoxicity neuroinflammation oxidative stress migraine nutrients diet |
| url | https://www.mdpi.com/2072-6643/15/18/3952 |
| work_keys_str_mv | AT fahimehmartami targetingglutamateneurotoxicitythroughdietarymanipulationpotentialtreatmentformigraine AT kathleenfholton targetingglutamateneurotoxicitythroughdietarymanipulationpotentialtreatmentformigraine |