Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response
Mitochondria are essential organelles that perform important roles in cell biologies such as ATP synthesis, metabolic regulation, immunomodulatory, and apoptosis. Parkinson’s disease (PD) is connected with mitochondrial neuronal damage related to mitochondrial unfolded protein response (mtUPR). Rosm...
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| Format: | Article |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.859978/full |
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| author | Guoen Cai Fabin Lin Fabin Lin Dihang Wu Dihang Wu Chenxin Lin Chenxin Lin Huiyun Chen Yicong Wei Huidan Weng Zhiting Chen Minxia Wu En Huang Zucheng Ye Qinyong Ye |
| author_facet | Guoen Cai Fabin Lin Fabin Lin Dihang Wu Dihang Wu Chenxin Lin Chenxin Lin Huiyun Chen Yicong Wei Huidan Weng Zhiting Chen Minxia Wu En Huang Zucheng Ye Qinyong Ye |
| author_sort | Guoen Cai |
| collection | DOAJ |
| description | Mitochondria are essential organelles that perform important roles in cell biologies such as ATP synthesis, metabolic regulation, immunomodulatory, and apoptosis. Parkinson’s disease (PD) is connected with mitochondrial neuronal damage related to mitochondrial unfolded protein response (mtUPR). Rosmarinic acid (RA) is a naturally occurring hydroxylated polyphenolic chemical found in the Boraginaceae and the Labiatae subfamily Nepetoideae. This study looked into RA’s protective effect against mitochondrial loss in the substantia nigra (SN) caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), the underlying mechanism associated with the mtUPR. Pretreatment with RA reduced motor impairments and dopaminergic neuronal degeneration in the SN of a mouse model injected with MPTP. Pretreatment of SH-SY5Y cells from cell viability loss, morphological damage, and oxidative stress. Furthermore, RA pre-injection suppressed MPTP-induced mtUPR, lowered the expression of HSPA9, HSPE1, CLPP, LONP1, and SIRT 4, and protected the MPTP-mice and SH-SY5Y cells from mitochondrial failure. These findings imply that RA can prevent Parkinson’s disease by preventing mitochondrial damage in dopaminergic neurons in Parkinson’s disease via alleviating mitochondrial unfolded protein response. |
| first_indexed | 2024-12-12T04:23:05Z |
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| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-12T04:23:05Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-fcdda279c2814c75a6a8865be54ffc662022-12-22T00:38:16ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-05-011310.3389/fphar.2022.859978859978Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein ResponseGuoen Cai0Fabin Lin1Fabin Lin2Dihang Wu3Dihang Wu4Chenxin Lin5Chenxin Lin6Huiyun Chen7Yicong Wei8Huidan Weng9Zhiting Chen10Minxia Wu11En Huang12Zucheng Ye13Qinyong Ye14Department of Neurology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Molecular Neurology, Institute of Clinical Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Molecular Neurology, Institute of Clinical Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, ChinaDepartment of Clinical Medicine, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Molecular Neurology, Institute of Clinical Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, ChinaDepartment of Clinical Medicine, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Molecular Neurology, Institute of Clinical Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, ChinaDepartment of Clinical Medicine, Fujian Medical University, Fuzhou, ChinaFujian Province Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, ChinaCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaDepartment of Neurology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Molecular Neurology, Institute of Clinical Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Molecular Neurology, Institute of Clinical Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, ChinaPublic Technology Service Center, Fujian Medical University, Fuzhou, ChinaFujian Key Laboratory of Brain Aging and Neurodegenerative Diseases, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, ChinaFujian Key Laboratory of Brain Aging and Neurodegenerative Diseases, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Molecular Neurology, Institute of Clinical Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, ChinaMitochondria are essential organelles that perform important roles in cell biologies such as ATP synthesis, metabolic regulation, immunomodulatory, and apoptosis. Parkinson’s disease (PD) is connected with mitochondrial neuronal damage related to mitochondrial unfolded protein response (mtUPR). Rosmarinic acid (RA) is a naturally occurring hydroxylated polyphenolic chemical found in the Boraginaceae and the Labiatae subfamily Nepetoideae. This study looked into RA’s protective effect against mitochondrial loss in the substantia nigra (SN) caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), the underlying mechanism associated with the mtUPR. Pretreatment with RA reduced motor impairments and dopaminergic neuronal degeneration in the SN of a mouse model injected with MPTP. Pretreatment of SH-SY5Y cells from cell viability loss, morphological damage, and oxidative stress. Furthermore, RA pre-injection suppressed MPTP-induced mtUPR, lowered the expression of HSPA9, HSPE1, CLPP, LONP1, and SIRT 4, and protected the MPTP-mice and SH-SY5Y cells from mitochondrial failure. These findings imply that RA can prevent Parkinson’s disease by preventing mitochondrial damage in dopaminergic neurons in Parkinson’s disease via alleviating mitochondrial unfolded protein response.https://www.frontiersin.org/articles/10.3389/fphar.2022.859978/fullrosmarinic acidmtUPRmitochondrial damagesubstantia nigraimmunlogy |
| spellingShingle | Guoen Cai Fabin Lin Fabin Lin Dihang Wu Dihang Wu Chenxin Lin Chenxin Lin Huiyun Chen Yicong Wei Huidan Weng Zhiting Chen Minxia Wu En Huang Zucheng Ye Qinyong Ye Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response Frontiers in Pharmacology rosmarinic acid mtUPR mitochondrial damage substantia nigra immunlogy |
| title | Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response |
| title_full | Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response |
| title_fullStr | Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response |
| title_full_unstemmed | Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response |
| title_short | Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response |
| title_sort | rosmarinic acid inhibits mitochondrial damage by alleviating unfolded protein response |
| topic | rosmarinic acid mtUPR mitochondrial damage substantia nigra immunlogy |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.859978/full |
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