Abundant heterotopic bone formation following use of rhBMP-2 in the treatment of acetabular bone defects during revision hip arthroplasty
Revision hip arthroplasty in the setting of periacetabular bone loss presents a significant challenge, as options for restoring bone loss are limited. Recombinant human bone morphogenetic protein-2 may offer a solution by promoting bone growth to restore bone stock before implant reimplantation. Her...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-06-01
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| Series: | Arthroplasty Today |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352344117301802 |
| _version_ | 1819063245728645120 |
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| author | Alexander Arzeno, MD Tim Wang, MD James I. Huddleston, III, MD |
| author_facet | Alexander Arzeno, MD Tim Wang, MD James I. Huddleston, III, MD |
| author_sort | Alexander Arzeno, MD |
| collection | DOAJ |
| description | Revision hip arthroplasty in the setting of periacetabular bone loss presents a significant challenge, as options for restoring bone loss are limited. Recombinant human bone morphogenetic protein-2 may offer a solution by promoting bone growth to restore bone stock before implant reimplantation. Here we present a case of a patient with a periprosthetic acetabulum fracture, resulting in pelvic discontinuity as the result of significant periacetabular bone loss. Using a staged approach, periacetabular bone stock was nearly entirely reconstituted using recombinant BMPs and allograft, which resulted in stable fixation, but with abundant heterotopic bone formation. Recombinant BMP-2 offers a useful tool for restoring bone stock in complex hip arthroplasty revision cases with periacetabular bone loss; however, caution must be used as overabundant bone growth as heterotopic ossification may result. |
| first_indexed | 2024-12-21T15:11:37Z |
| format | Article |
| id | doaj.art-fcdf503d6aaa4df3b742b7a7173a5472 |
| institution | Directory Open Access Journal |
| issn | 2352-3441 |
| language | English |
| last_indexed | 2024-12-21T15:11:37Z |
| publishDate | 2018-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arthroplasty Today |
| spelling | doaj.art-fcdf503d6aaa4df3b742b7a7173a54722022-12-21T18:59:17ZengElsevierArthroplasty Today2352-34412018-06-014216216810.1016/j.artd.2017.12.004Abundant heterotopic bone formation following use of rhBMP-2 in the treatment of acetabular bone defects during revision hip arthroplastyAlexander Arzeno, MDTim Wang, MDJames I. Huddleston, III, MDRevision hip arthroplasty in the setting of periacetabular bone loss presents a significant challenge, as options for restoring bone loss are limited. Recombinant human bone morphogenetic protein-2 may offer a solution by promoting bone growth to restore bone stock before implant reimplantation. Here we present a case of a patient with a periprosthetic acetabulum fracture, resulting in pelvic discontinuity as the result of significant periacetabular bone loss. Using a staged approach, periacetabular bone stock was nearly entirely reconstituted using recombinant BMPs and allograft, which resulted in stable fixation, but with abundant heterotopic bone formation. Recombinant BMP-2 offers a useful tool for restoring bone stock in complex hip arthroplasty revision cases with periacetabular bone loss; however, caution must be used as overabundant bone growth as heterotopic ossification may result.http://www.sciencedirect.com/science/article/pii/S2352344117301802Revision arthroplastyBone defectsrhBMP-2 |
| spellingShingle | Alexander Arzeno, MD Tim Wang, MD James I. Huddleston, III, MD Abundant heterotopic bone formation following use of rhBMP-2 in the treatment of acetabular bone defects during revision hip arthroplasty Arthroplasty Today Revision arthroplasty Bone defects rhBMP-2 |
| title | Abundant heterotopic bone formation following use of rhBMP-2 in the treatment of acetabular bone defects during revision hip arthroplasty |
| title_full | Abundant heterotopic bone formation following use of rhBMP-2 in the treatment of acetabular bone defects during revision hip arthroplasty |
| title_fullStr | Abundant heterotopic bone formation following use of rhBMP-2 in the treatment of acetabular bone defects during revision hip arthroplasty |
| title_full_unstemmed | Abundant heterotopic bone formation following use of rhBMP-2 in the treatment of acetabular bone defects during revision hip arthroplasty |
| title_short | Abundant heterotopic bone formation following use of rhBMP-2 in the treatment of acetabular bone defects during revision hip arthroplasty |
| title_sort | abundant heterotopic bone formation following use of rhbmp 2 in the treatment of acetabular bone defects during revision hip arthroplasty |
| topic | Revision arthroplasty Bone defects rhBMP-2 |
| url | http://www.sciencedirect.com/science/article/pii/S2352344117301802 |
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