Absence of the Klotho Function Causes Cornea Degeneration with Specific Features Resembling Fuchs Endothelial Corneal Dystrophy and Bullous Keratopathy

Absence of the Klotho Function Causes Cornea Degeneration with Specific Features Resembling Fuchs Endothelial Corneal Dystrophy and Bullous Keratopathy

The Klotho loss-of-function mutation is known to cause accelerated senescence in many organs, but its effects on the cornea have not been published. The present study aims to investigate the effects of the Klotho null mutation on cornea degeneration and to characterize the pathological features. Mou...

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Bibliographic Details
Main Authors: Chun-Yen Wu, Da-Fong Song, Zhi-Jia Chen, Chao-Sheng Hu, David Pei-Cheng Lin, Han-Hsin Chang
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Biology
Subjects:
Klotho null mutation
age-related cornea degeneration
Fuchs endothelial corneal dystrophy
bullous keratopathy
dry eye disease
murine model
Online Access:https://www.mdpi.com/2079-7737/13/3/133

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