Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines

Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines

A novel one-pot multicomponent reaction to synthesize substituted imidazopyrazines is described. In brief, 1<i>H</i>-(imidazol-5-yl)-<i>N</i>-substituted methanamines react with aldehydes and isocyanides in methanol at room temperature to give imidazopyrazine derivatives in e...

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Bibliographic Details
Main Authors: Ubaldina Galli, Rejdia Hysenlika, Fiorella Meneghetti, Erika Del Grosso, Sveva Pelliccia, Ettore Novellino, Mariateresa Giustiniano, Gian Cesare Tron
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Molecules
Subjects:
multicomponent reactions
interrupted Ugi reactions
isocyanides
Online Access:https://www.mdpi.com/1420-3049/24/10/1959

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