BCG revaccination in adults enhances pro-inflammatory markers of trained immunity along with anti-inflammatory pathways

BCG revaccination in adults enhances pro-inflammatory markers of trained immunity along with anti-inflammatory pathways

Summary: This study characterized mechanisms of Bacille Calmette-Guérin (BCG) revaccination-induced trained immunity (TI) in India. Adults, BCG vaccinated at birth, were sampled longitudinally before and after a second BCG dose. BCG revaccination significantly elevated tumor necrosis factor alpha (T...

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Bibliographic Details
Main Authors: Asma Ahmed, Himanshu Tripathi, Krista E. van Meijgaarden, Nirutha Chetan Kumar, Vasista Adiga, Srabanti Rakshit, Chaitra Parthiban, Sharon Eveline J, George D’Souza, Mary Dias, Tom H.M. Ottenhoff, Mihai G. Netea, Simone A. Joosten, Annapurna Vyakarnam
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:iScience
Subjects:
Molecular biology
Immunology
Immune response
Immunity
Omics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223019661

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