Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR

Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR

<p>Abstract</p> <p>Background</p> <p>In a previous genome-wide analysis of FXR binding to hepatic chromatin, we noticed that an extra nuclear receptor (NR) half-site was co-enriched close to the FXR binding IR-1 elements and we provided limited support that the monomeri...

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Bibliographic Details
Main Authors: Chong Hansook, Biesinger Jacob, Seo Young-Kyo, Xie Xiaohui, Osborne Timothy F
Format: Article
Language:English
Published: BMC 2012-02-01
Series:BMC Genomics
Subjects:
LRH-1
FXR
ChIP-seq
lipid metabolism
Online Access:http://www.biomedcentral.com/1471-2164/13/51

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