Pegylated magnetic carbon nanotubes for efficient and safe delivery of poorly water-soluble platinum anticancer drugs
In this work, a new PEGylated magnetic carbon nanotube was developed for efficient and safe delivery of poorly water-soluble platinum anticancer drugs. Nanocarriers based on PEGylated magnetic carbon nanotubes were chemically synthesized through simple methods and finally platinum(II) complex conjug...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715623005143 |
| _version_ | 1797371458295431168 |
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| author | Faezeh Moniriyan Seyed Jamal Tabatabaei Rezaei Seyyed Javad Sabounchei |
| author_facet | Faezeh Moniriyan Seyed Jamal Tabatabaei Rezaei Seyyed Javad Sabounchei |
| author_sort | Faezeh Moniriyan |
| collection | DOAJ |
| description | In this work, a new PEGylated magnetic carbon nanotube was developed for efficient and safe delivery of poorly water-soluble platinum anticancer drugs. Nanocarriers based on PEGylated magnetic carbon nanotubes were chemically synthesized through simple methods and finally platinum(II) complex conjugated to the synthesized delivery system (carbon nanotubes/polyethyleneglycol@Fe3O4/CPTMS@Cis-dichloro-bis(5-(4-pyridyl)-5-phenylhydantoin)platinum(II)) (CNTs/PEG@M/CPTMS@CisPt(II)). This nanomaterial was characterized by Transmission electron microscopes (TEM), Scanning electron microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDS), X-Ray diffraction analysis (XRD), Ultraviolet–visible (UV–Vis) spectroscopy, Inductively coupled plasma mass spectrometry (ICP-MS), Fourier-transform infrared spectroscopy (FT-IR), Elemental mapping, Raman spectroscopy, and Nuclear Magnetic Resonance (NMR) analysis. The pattern of drug release from the CNTs/PEG@M/CPTMS@CisPt(II) was affected by pH at a certain temperature and time. In vitro cytotoxicity studies shown that despite the acceptable biocompatibility of the drug-free carrier, the drug-conjugated carrier has a good efficiency in limiting the growth and killing cancer cells. These findings revealed that CNTs/PEG@M/CPTMS@CisPt(II) carrier may provide a promising approach for delivery of the anticancer drugs to cancer cells. |
| first_indexed | 2024-03-08T18:19:09Z |
| format | Article |
| id | doaj.art-fce2d3db7df641e58544ff0261268331 |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-03-08T18:19:09Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-fce2d3db7df641e58544ff02612683312023-12-31T04:26:13ZengElsevierResults in Chemistry2211-71562024-01-017101275Pegylated magnetic carbon nanotubes for efficient and safe delivery of poorly water-soluble platinum anticancer drugsFaezeh Moniriyan0Seyed Jamal Tabatabaei Rezaei1Seyyed Javad Sabounchei2Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran; Corresponding authors.Faculty of Renewable Energy, Department of Applied Chemistry, Urmia University of Technology, Urmia, Iran; Corresponding authors.Faculty of Chemistry, Bu-Ali Sina University, Hamedan, IranIn this work, a new PEGylated magnetic carbon nanotube was developed for efficient and safe delivery of poorly water-soluble platinum anticancer drugs. Nanocarriers based on PEGylated magnetic carbon nanotubes were chemically synthesized through simple methods and finally platinum(II) complex conjugated to the synthesized delivery system (carbon nanotubes/polyethyleneglycol@Fe3O4/CPTMS@Cis-dichloro-bis(5-(4-pyridyl)-5-phenylhydantoin)platinum(II)) (CNTs/PEG@M/CPTMS@CisPt(II)). This nanomaterial was characterized by Transmission electron microscopes (TEM), Scanning electron microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDS), X-Ray diffraction analysis (XRD), Ultraviolet–visible (UV–Vis) spectroscopy, Inductively coupled plasma mass spectrometry (ICP-MS), Fourier-transform infrared spectroscopy (FT-IR), Elemental mapping, Raman spectroscopy, and Nuclear Magnetic Resonance (NMR) analysis. The pattern of drug release from the CNTs/PEG@M/CPTMS@CisPt(II) was affected by pH at a certain temperature and time. In vitro cytotoxicity studies shown that despite the acceptable biocompatibility of the drug-free carrier, the drug-conjugated carrier has a good efficiency in limiting the growth and killing cancer cells. These findings revealed that CNTs/PEG@M/CPTMS@CisPt(II) carrier may provide a promising approach for delivery of the anticancer drugs to cancer cells.http://www.sciencedirect.com/science/article/pii/S2211715623005143Drug conjugateMagnetic carbon nanotubesCisplatinHydantoinDrug delivery |
| spellingShingle | Faezeh Moniriyan Seyed Jamal Tabatabaei Rezaei Seyyed Javad Sabounchei Pegylated magnetic carbon nanotubes for efficient and safe delivery of poorly water-soluble platinum anticancer drugs Results in Chemistry Drug conjugate Magnetic carbon nanotubes Cisplatin Hydantoin Drug delivery |
| title | Pegylated magnetic carbon nanotubes for efficient and safe delivery of poorly water-soluble platinum anticancer drugs |
| title_full | Pegylated magnetic carbon nanotubes for efficient and safe delivery of poorly water-soluble platinum anticancer drugs |
| title_fullStr | Pegylated magnetic carbon nanotubes for efficient and safe delivery of poorly water-soluble platinum anticancer drugs |
| title_full_unstemmed | Pegylated magnetic carbon nanotubes for efficient and safe delivery of poorly water-soluble platinum anticancer drugs |
| title_short | Pegylated magnetic carbon nanotubes for efficient and safe delivery of poorly water-soluble platinum anticancer drugs |
| title_sort | pegylated magnetic carbon nanotubes for efficient and safe delivery of poorly water soluble platinum anticancer drugs |
| topic | Drug conjugate Magnetic carbon nanotubes Cisplatin Hydantoin Drug delivery |
| url | http://www.sciencedirect.com/science/article/pii/S2211715623005143 |
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