SARS‐CoV‐2 triggers complement activation through interactions with heparan sulfate

SARS‐CoV‐2 triggers complement activation through interactions with heparan sulfate

Abstract Objectives To determine whether SARS‐CoV‐2 can trigger complement activation, the pathways that are involved and the functional significance of the resultant effect. Methods SARS‐CoV‐2 was inoculated into a human lepirudin‐anticoagulated whole blood model, which contains a full repertoire o...

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Bibliographic Details
Main Authors: Martin W Lo, Alberto A Amarilla, John D Lee, Eduardo A Albornoz, Naphak Modhiran, Richard J Clark, Vito Ferro, Mohit Chhabra, Alexander A Khromykh, Daniel Watterson, Trent M Woodruff
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Clinical & Translational Immunology
Subjects:
alternative pathway
complement
coronavirus
heparan sulfate
leukocyte activation
SARS‐CoV‐2
Online Access:https://doi.org/10.1002/cti2.1413

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