Advances in the Early Diagnosis of Pancreatic Ductal Adenocarcinoma and Premalignant Pancreatic Lesions
Pancreatic cancer is one of the most lethal human malignancies, in part because it is often diagnosed at late stages when surgery and systemic therapies are either unfeasible or ineffective. Therefore, diagnosing pancreatic cancer in earlier stages is important for effective treatment. However, beca...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/6/1687 |
| _version_ | 1827738436507795456 |
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| author | Reiko Yamada Junya Tsuboi Yumi Murashima Takamitsu Tanaka Kenji Nose Hayato Nakagawa |
| author_facet | Reiko Yamada Junya Tsuboi Yumi Murashima Takamitsu Tanaka Kenji Nose Hayato Nakagawa |
| author_sort | Reiko Yamada |
| collection | DOAJ |
| description | Pancreatic cancer is one of the most lethal human malignancies, in part because it is often diagnosed at late stages when surgery and systemic therapies are either unfeasible or ineffective. Therefore, diagnosing pancreatic cancer in earlier stages is important for effective treatment. However, because the signs and symptoms may be nonspecific and not apparent until the disease is at a late stage, the timely diagnoses of pancreatic cancer can be difficult to achieve. Recent studies have shown that selective screening and increased usage of biomarkers could improve the early diagnosis of pancreatic cancer. In this review, we discuss recent advancements in the early detection of pancreatic ductal carcinoma and precancerous lesions. These include innovations in imaging modalities, the diagnostic utility of various biomarkers, biopsy techniques, and population-based surveillance approaches. Additionally, we discuss how machine learning methods are being applied to develop integrated methods of identifying individuals at high risk of developing pancreatic disease. In the future, the overall survival of pancreatic cancer patients could be improved by the development and adoption of these new methods and techniques. |
| first_indexed | 2024-03-11T02:45:19Z |
| format | Article |
| id | doaj.art-fce3e51e99d04a7ea5743b77d2bc099b |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T02:45:19Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-fce3e51e99d04a7ea5743b77d2bc099b2023-11-18T09:26:48ZengMDPI AGBiomedicines2227-90592023-06-01116168710.3390/biomedicines11061687Advances in the Early Diagnosis of Pancreatic Ductal Adenocarcinoma and Premalignant Pancreatic LesionsReiko Yamada0Junya Tsuboi1Yumi Murashima2Takamitsu Tanaka3Kenji Nose4Hayato Nakagawa5Department of Gastroenterology and Hepatology, School of Medicine, Mie University, Tsu 514-8507, JapanDepartment of Gastroenterology and Hepatology, School of Medicine, Mie University, Tsu 514-8507, JapanDepartment of Gastroenterology and Hepatology, School of Medicine, Mie University, Tsu 514-8507, JapanDepartment of Gastroenterology and Hepatology, School of Medicine, Mie University, Tsu 514-8507, JapanDepartment of Gastroenterology and Hepatology, School of Medicine, Mie University, Tsu 514-8507, JapanDepartment of Gastroenterology and Hepatology, School of Medicine, Mie University, Tsu 514-8507, JapanPancreatic cancer is one of the most lethal human malignancies, in part because it is often diagnosed at late stages when surgery and systemic therapies are either unfeasible or ineffective. Therefore, diagnosing pancreatic cancer in earlier stages is important for effective treatment. However, because the signs and symptoms may be nonspecific and not apparent until the disease is at a late stage, the timely diagnoses of pancreatic cancer can be difficult to achieve. Recent studies have shown that selective screening and increased usage of biomarkers could improve the early diagnosis of pancreatic cancer. In this review, we discuss recent advancements in the early detection of pancreatic ductal carcinoma and precancerous lesions. These include innovations in imaging modalities, the diagnostic utility of various biomarkers, biopsy techniques, and population-based surveillance approaches. Additionally, we discuss how machine learning methods are being applied to develop integrated methods of identifying individuals at high risk of developing pancreatic disease. In the future, the overall survival of pancreatic cancer patients could be improved by the development and adoption of these new methods and techniques.https://www.mdpi.com/2227-9059/11/6/1687pancreatic cancerdiagnosticsbiomarkershereditary conditionsEUSEUS-FNA |
| spellingShingle | Reiko Yamada Junya Tsuboi Yumi Murashima Takamitsu Tanaka Kenji Nose Hayato Nakagawa Advances in the Early Diagnosis of Pancreatic Ductal Adenocarcinoma and Premalignant Pancreatic Lesions Biomedicines pancreatic cancer diagnostics biomarkers hereditary conditions EUS EUS-FNA |
| title | Advances in the Early Diagnosis of Pancreatic Ductal Adenocarcinoma and Premalignant Pancreatic Lesions |
| title_full | Advances in the Early Diagnosis of Pancreatic Ductal Adenocarcinoma and Premalignant Pancreatic Lesions |
| title_fullStr | Advances in the Early Diagnosis of Pancreatic Ductal Adenocarcinoma and Premalignant Pancreatic Lesions |
| title_full_unstemmed | Advances in the Early Diagnosis of Pancreatic Ductal Adenocarcinoma and Premalignant Pancreatic Lesions |
| title_short | Advances in the Early Diagnosis of Pancreatic Ductal Adenocarcinoma and Premalignant Pancreatic Lesions |
| title_sort | advances in the early diagnosis of pancreatic ductal adenocarcinoma and premalignant pancreatic lesions |
| topic | pancreatic cancer diagnostics biomarkers hereditary conditions EUS EUS-FNA |
| url | https://www.mdpi.com/2227-9059/11/6/1687 |
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