The Urinary Concentration of Trefoil Factor 3 (TFF3) in the Term and Preterm Neonates
Background: Distinguishing between a pathologic state and renal development is important in neonatology. Because the assessment of serum creatinine in neonates is not reliable, better biomarkers are needed. Trefoil factor 3 (TFF3) is proposed as a biomarker of kidney injury. The study aimed to asses...
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MDPI AG
2023-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/15/4936 |
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| author | Monika Kamianowska Agnieszka Rybi-Szumińska Aleksandra Kamianowska Mateusz Maciejczyk Katarzyna Sołomianko Alicja Koput Anna Wasilewska |
| author_facet | Monika Kamianowska Agnieszka Rybi-Szumińska Aleksandra Kamianowska Mateusz Maciejczyk Katarzyna Sołomianko Alicja Koput Anna Wasilewska |
| author_sort | Monika Kamianowska |
| collection | DOAJ |
| description | Background: Distinguishing between a pathologic state and renal development is important in neonatology. Because the assessment of serum creatinine in neonates is not reliable, better biomarkers are needed. Trefoil factor 3 (TFF3) is proposed as a biomarker of kidney injury. The study aimed to assess its urinary concentration in healthy term and stable preterm neonates. Material and methods: The study included 80 term and 20 preterm neonates born in the Department of Perinatology of the University Clinical Hospital in Bialystok. Urine was obtained from the term neonates on the 1st day of life and from the preterm neonates on the 1st, 8th, 15th and 22nd day of life. The urinary concentration of TFF3 was determined using a commercially available immunoassay and was normalized for the urinary creatinine concentration (cr.). Results: The values of TFF3/cr. were higher in the preterm than in the term neonates (<i>p</i> < 0.05) (median (Q1–Q3): 1486.85 (614.92–3559.18) and 317.29 (68.07–671.40) ng/mg cr.). They did not differ in the subsequent days of the preterm neonates’ lives. The ROC curve for TFF3/cr. in the preterm and term neonates showed AUC = 0.751 (cut-off value = 1684.25 ng/mg cr.). Conclusions: Prematurity is associated with higher urinary excretion of TFF3. Male gender is associated with an increased urinary TFF3 excretion in term neonates. |
| first_indexed | 2024-03-11T00:24:59Z |
| format | Article |
| id | doaj.art-fce76f70ec9f48ed807792491b75d634 |
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| language | English |
| last_indexed | 2024-03-11T00:24:59Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-fce76f70ec9f48ed807792491b75d6342023-11-18T23:07:11ZengMDPI AGJournal of Clinical Medicine2077-03832023-07-011215493610.3390/jcm12154936The Urinary Concentration of Trefoil Factor 3 (TFF3) in the Term and Preterm NeonatesMonika Kamianowska0Agnieszka Rybi-Szumińska1Aleksandra Kamianowska2Mateusz Maciejczyk3Katarzyna Sołomianko4Alicja Koput5Anna Wasilewska6Department of Neonatology and Neonatal Intensive Care, Medical University of Bialystok, M. C. Sklodowskiej 24a Street, 15-276 Białystok, PolandDepartment of Pediatrics and Nephrology, Medical University of Bialystok, 15-269 Bialystok, PolandDepartment of Pediatrics and Nephrology, Medical University of Bialystok, 15-269 Bialystok, PolandDepartment of Hygiene, Epidemiology and Ergonomic, Medical University of Bialystok, 15-269 Bialystok, PolandDepartment of Neonatology and Neonatal Intensive Care, Medical University of Bialystok, M. C. Sklodowskiej 24a Street, 15-276 Białystok, PolandDepartment of Pediatric Laboratory Diagnostics, Medical University of Bialystok, 15-269 Bialystok, PolandDepartment of Pediatrics and Nephrology, Medical University of Bialystok, 15-269 Bialystok, PolandBackground: Distinguishing between a pathologic state and renal development is important in neonatology. Because the assessment of serum creatinine in neonates is not reliable, better biomarkers are needed. Trefoil factor 3 (TFF3) is proposed as a biomarker of kidney injury. The study aimed to assess its urinary concentration in healthy term and stable preterm neonates. Material and methods: The study included 80 term and 20 preterm neonates born in the Department of Perinatology of the University Clinical Hospital in Bialystok. Urine was obtained from the term neonates on the 1st day of life and from the preterm neonates on the 1st, 8th, 15th and 22nd day of life. The urinary concentration of TFF3 was determined using a commercially available immunoassay and was normalized for the urinary creatinine concentration (cr.). Results: The values of TFF3/cr. were higher in the preterm than in the term neonates (<i>p</i> < 0.05) (median (Q1–Q3): 1486.85 (614.92–3559.18) and 317.29 (68.07–671.40) ng/mg cr.). They did not differ in the subsequent days of the preterm neonates’ lives. The ROC curve for TFF3/cr. in the preterm and term neonates showed AUC = 0.751 (cut-off value = 1684.25 ng/mg cr.). Conclusions: Prematurity is associated with higher urinary excretion of TFF3. Male gender is associated with an increased urinary TFF3 excretion in term neonates.https://www.mdpi.com/2077-0383/12/15/4936Trefoil factor 3biomarkerskidneyneonateskidney disease |
| spellingShingle | Monika Kamianowska Agnieszka Rybi-Szumińska Aleksandra Kamianowska Mateusz Maciejczyk Katarzyna Sołomianko Alicja Koput Anna Wasilewska The Urinary Concentration of Trefoil Factor 3 (TFF3) in the Term and Preterm Neonates Journal of Clinical Medicine Trefoil factor 3 biomarkers kidney neonates kidney disease |
| title | The Urinary Concentration of Trefoil Factor 3 (TFF3) in the Term and Preterm Neonates |
| title_full | The Urinary Concentration of Trefoil Factor 3 (TFF3) in the Term and Preterm Neonates |
| title_fullStr | The Urinary Concentration of Trefoil Factor 3 (TFF3) in the Term and Preterm Neonates |
| title_full_unstemmed | The Urinary Concentration of Trefoil Factor 3 (TFF3) in the Term and Preterm Neonates |
| title_short | The Urinary Concentration of Trefoil Factor 3 (TFF3) in the Term and Preterm Neonates |
| title_sort | urinary concentration of trefoil factor 3 tff3 in the term and preterm neonates |
| topic | Trefoil factor 3 biomarkers kidney neonates kidney disease |
| url | https://www.mdpi.com/2077-0383/12/15/4936 |
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