Metabolic and Proteomic Profiles Associated with Immune Responses Induced by Different Inactivated SARS-CoV-2 Vaccine Candidates
Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019, the virus has been mutating continuously, resulting in the continuous emergence of variants and creating challenges for epidemic prevention and control. Here, we immunized mice with different vaccine ca...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/18/10644 |
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| author | Shouzhi Yu Yao He Wenheng Ji Rong Yang Yuxiu Zhao Yan Li Yingwei Liu Ling Ding Meng Ma Hui Wang Xiaoming Yang |
| author_facet | Shouzhi Yu Yao He Wenheng Ji Rong Yang Yuxiu Zhao Yan Li Yingwei Liu Ling Ding Meng Ma Hui Wang Xiaoming Yang |
| author_sort | Shouzhi Yu |
| collection | DOAJ |
| description | Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019, the virus has been mutating continuously, resulting in the continuous emergence of variants and creating challenges for epidemic prevention and control. Here, we immunized mice with different vaccine candidates, revealing the immune, protein, and metabolomic changes that take place in vaccines composed of different variants. We found that the prototype strain and Delta- and Omicron-variant inactivated vaccine candidates could all induce a high level of neutralizing antibodies and cellular immunity responses in mice. Next, we found that the metabolic and protein profiles were changed, showing a positive association with immune responses, and the level of the change was distinct in different inactivated vaccines, indicating that amino acid variations could affect metabolomics and proteomics. Our findings reveal differences between vaccines at the metabolomic and proteomic levels. These insights provide a novel direction for the immune evaluation of vaccines and could be used to guide novel strategies for vaccine design. |
| first_indexed | 2024-03-09T23:45:21Z |
| format | Article |
| id | doaj.art-fce827476b9f41379535f210489a946d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:45:21Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-fce827476b9f41379535f210489a946d2023-11-23T16:45:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-09-0123181064410.3390/ijms231810644Metabolic and Proteomic Profiles Associated with Immune Responses Induced by Different Inactivated SARS-CoV-2 Vaccine CandidatesShouzhi Yu0Yao He1Wenheng Ji2Rong Yang3Yuxiu Zhao4Yan Li5Yingwei Liu6Ling Ding7Meng Ma8Hui Wang9Xiaoming Yang10Beijing Institute of Biological Products Company Limited, Beijing 100176, ChinaBeijing Institute of Biological Products Company Limited, Beijing 100176, ChinaBeijing Institute of Biological Products Company Limited, Beijing 100176, ChinaBeijing Institute of Biological Products Company Limited, Beijing 100176, ChinaBeijing Institute of Biological Products Company Limited, Beijing 100176, ChinaBeijing Institute of Biological Products Company Limited, Beijing 100176, ChinaBeijing Institute of Biological Products Company Limited, Beijing 100176, ChinaBeijing Institute of Biological Products Company Limited, Beijing 100176, ChinaBeijing Institute of Biological Products Company Limited, Beijing 100176, ChinaBeijing Institute of Biological Products Company Limited, Beijing 100176, ChinaChina National Biotec Group Company Limited, Beijing 100024, ChinaSince the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019, the virus has been mutating continuously, resulting in the continuous emergence of variants and creating challenges for epidemic prevention and control. Here, we immunized mice with different vaccine candidates, revealing the immune, protein, and metabolomic changes that take place in vaccines composed of different variants. We found that the prototype strain and Delta- and Omicron-variant inactivated vaccine candidates could all induce a high level of neutralizing antibodies and cellular immunity responses in mice. Next, we found that the metabolic and protein profiles were changed, showing a positive association with immune responses, and the level of the change was distinct in different inactivated vaccines, indicating that amino acid variations could affect metabolomics and proteomics. Our findings reveal differences between vaccines at the metabolomic and proteomic levels. These insights provide a novel direction for the immune evaluation of vaccines and could be used to guide novel strategies for vaccine design.https://www.mdpi.com/1422-0067/23/18/10644COVID-19metabolismproteomicsvaccines |
| spellingShingle | Shouzhi Yu Yao He Wenheng Ji Rong Yang Yuxiu Zhao Yan Li Yingwei Liu Ling Ding Meng Ma Hui Wang Xiaoming Yang Metabolic and Proteomic Profiles Associated with Immune Responses Induced by Different Inactivated SARS-CoV-2 Vaccine Candidates International Journal of Molecular Sciences COVID-19 metabolism proteomics vaccines |
| title | Metabolic and Proteomic Profiles Associated with Immune Responses Induced by Different Inactivated SARS-CoV-2 Vaccine Candidates |
| title_full | Metabolic and Proteomic Profiles Associated with Immune Responses Induced by Different Inactivated SARS-CoV-2 Vaccine Candidates |
| title_fullStr | Metabolic and Proteomic Profiles Associated with Immune Responses Induced by Different Inactivated SARS-CoV-2 Vaccine Candidates |
| title_full_unstemmed | Metabolic and Proteomic Profiles Associated with Immune Responses Induced by Different Inactivated SARS-CoV-2 Vaccine Candidates |
| title_short | Metabolic and Proteomic Profiles Associated with Immune Responses Induced by Different Inactivated SARS-CoV-2 Vaccine Candidates |
| title_sort | metabolic and proteomic profiles associated with immune responses induced by different inactivated sars cov 2 vaccine candidates |
| topic | COVID-19 metabolism proteomics vaccines |
| url | https://www.mdpi.com/1422-0067/23/18/10644 |
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