Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson’s disease
Parkinson’s disease (PD) is a progressive neurodegenerative disorder, which is characterized by neuroinflammation, dopaminergic neuronal cell death and motor dysfunction, and for which there are no proven effective treatments. The negative correlation between tobacco consumption and PD suggests that...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2015-01-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00340/full |
| _version_ | 1824023520315703296 |
|---|---|
| author | George E. eBarreto Alexander eIarkov Alexander eIarkov Valentina eEcheverria Moran Valentina eEcheverria Moran |
| author_facet | George E. eBarreto Alexander eIarkov Alexander eIarkov Valentina eEcheverria Moran Valentina eEcheverria Moran |
| author_sort | George E. eBarreto |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is a progressive neurodegenerative disorder, which is characterized by neuroinflammation, dopaminergic neuronal cell death and motor dysfunction, and for which there are no proven effective treatments. The negative correlation between tobacco consumption and PD suggests that tobacco-derived compounds can be beneficial against PD. Nicotine, the more studied alkaloid derived from tobacco, is considered to be responsible for the beneficial behavioral and neurological effects of tobacco use in PD. However, several metabolites of nicotine such as cotinine also increase in the brain after nicotine administration. The effect of nicotine and some of its derivatives on dopaminergic neurons viability, neuroinflammation, and motor and memory functions, have been investigated using cellular and rodent models of PD. Current evidence shows that nicotine, and some of its derivatives diminish oxidative stress and neuroinflammation in the brain and improve synaptic plasticity and neuronal survival of dopaminergic neurons. In vivo these effects resulted in improvements in mood, motor skills and memory in subjects suffering from PD pathology. In this review, we discuss the potential benefits of nicotine and its derivatives for treating PD. |
| first_indexed | 2024-12-19T09:35:29Z |
| format | Article |
| id | doaj.art-fce939f872084c37a078609c5b442056 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-19T09:35:29Z |
| publishDate | 2015-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-fce939f872084c37a078609c5b4420562022-12-21T20:27:32ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652015-01-01610.3389/fnagi.2014.00340123750Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson’s diseaseGeorge E. eBarreto0Alexander eIarkov1Alexander eIarkov2Valentina eEcheverria Moran3Valentina eEcheverria Moran4Pontificia Universidad Javeriana,Universidad Autónoma de ChileBay Pines VA Healthcare SystemUniversidad Autónoma de ChileBay Pines VA Healthcare SystemParkinson’s disease (PD) is a progressive neurodegenerative disorder, which is characterized by neuroinflammation, dopaminergic neuronal cell death and motor dysfunction, and for which there are no proven effective treatments. The negative correlation between tobacco consumption and PD suggests that tobacco-derived compounds can be beneficial against PD. Nicotine, the more studied alkaloid derived from tobacco, is considered to be responsible for the beneficial behavioral and neurological effects of tobacco use in PD. However, several metabolites of nicotine such as cotinine also increase in the brain after nicotine administration. The effect of nicotine and some of its derivatives on dopaminergic neurons viability, neuroinflammation, and motor and memory functions, have been investigated using cellular and rodent models of PD. Current evidence shows that nicotine, and some of its derivatives diminish oxidative stress and neuroinflammation in the brain and improve synaptic plasticity and neuronal survival of dopaminergic neurons. In vivo these effects resulted in improvements in mood, motor skills and memory in subjects suffering from PD pathology. In this review, we discuss the potential benefits of nicotine and its derivatives for treating PD.http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00340/fullCotinineNicotineParkinson Diseasebeta amyloidsynucleinopathiesAkt (PKB) |
| spellingShingle | George E. eBarreto Alexander eIarkov Alexander eIarkov Valentina eEcheverria Moran Valentina eEcheverria Moran Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson’s disease Frontiers in Aging Neuroscience Cotinine Nicotine Parkinson Disease beta amyloid synucleinopathies Akt (PKB) |
| title | Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson’s disease |
| title_full | Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson’s disease |
| title_fullStr | Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson’s disease |
| title_full_unstemmed | Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson’s disease |
| title_short | Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson’s disease |
| title_sort | beneficial effects of nicotine cotinine and its metabolites as potential agents for parkinson s disease |
| topic | Cotinine Nicotine Parkinson Disease beta amyloid synucleinopathies Akt (PKB) |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00340/full |
| work_keys_str_mv | AT georgeeebarreto beneficialeffectsofnicotinecotinineanditsmetabolitesaspotentialagentsforparkinsonsdisease AT alexandereiarkov beneficialeffectsofnicotinecotinineanditsmetabolitesaspotentialagentsforparkinsonsdisease AT alexandereiarkov beneficialeffectsofnicotinecotinineanditsmetabolitesaspotentialagentsforparkinsonsdisease AT valentinaeecheverriamoran beneficialeffectsofnicotinecotinineanditsmetabolitesaspotentialagentsforparkinsonsdisease AT valentinaeecheverriamoran beneficialeffectsofnicotinecotinineanditsmetabolitesaspotentialagentsforparkinsonsdisease |