n-3 enriched Fish oil diet enhanced intestinal barrier integrity in broilers after Eimeria infection
ABSTRACT: Coccidiosis caused by Eimeria spp. results in substantial economic losses in the poultry industry. The objective of this study was to investigate the effects of dietary supplementation with n-3 polyunsaturated fatty acids-enriched fish oil on growth performance, intestinal barrier integrit...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Poultry Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579124002396 |
| _version_ | 1827238731180933120 |
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| author | Yuguo Hou Tompkins Venkata Sesha Reddy Choppa Woo Kyun Kim |
| author_facet | Yuguo Hou Tompkins Venkata Sesha Reddy Choppa Woo Kyun Kim |
| author_sort | Yuguo Hou Tompkins |
| collection | DOAJ |
| description | ABSTRACT: Coccidiosis caused by Eimeria spp. results in substantial economic losses in the poultry industry. The objective of this study was to investigate the effects of dietary supplementation with n-3 polyunsaturated fatty acids-enriched fish oil on growth performance, intestinal barrier integrity, and intestinal immune response of broilers challenged with Eimeria spp. A total of 576 fourteen-day-old broilers were randomly assigned in a completely randomized design with a 3 × 2 factorial arrangement, comprising 2 diets supplemented with either 5% fish oil or 5% soybean oil, and 3 Eimeria spp. infection levels: a nonchallenge control, a low dose of Eimeria challenge, and a high challenge dose. The results of the study revealed significant interactions between diet and Eimeria challenge to parameters of gut barrier integrity and feed intake. A significant interaction was observed in feed intake between 5 and 8 d postinfection (DPI), where the fish oil groups exhibited a higher amount of feed intake compared to the soybean oil diet groups after coccidiosis infection. The effects of the fish oil diet resulted in enhanced gut barrier integrity, as evidenced by a trend of decreased gastrointestinal leakage and a lower mean of small intestine lesion scores after Eimeria challenge. Additionally, significant interactions were noted between Eimeria spp. challenge and diet regarding jejunal crypt depth. The positive impact of the fish oil diet was particularly noticeable with the high Eimeria challenge dose. Overall, these findings underscore the relationship between the fish oil diet and Eimeria challenge on broiler chicken intestinal health. Dietary supplementation of fish oil has the potential to maintain small intestine barrier integrity with severe Eimeria infection conditions. |
| first_indexed | 2024-04-24T16:51:17Z |
| format | Article |
| id | doaj.art-fceb35a2ec7243ecb44cb89168b2def3 |
| institution | Directory Open Access Journal |
| issn | 0032-5791 |
| language | English |
| last_indexed | 2025-03-21T20:57:27Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Poultry Science |
| spelling | doaj.art-fceb35a2ec7243ecb44cb89168b2def32024-05-31T05:39:31ZengElsevierPoultry Science0032-57912024-06-011036103660n-3 enriched Fish oil diet enhanced intestinal barrier integrity in broilers after Eimeria infectionYuguo Hou Tompkins0Venkata Sesha Reddy Choppa1Woo Kyun Kim2Department of Poultry Science, University of Georgia, Athens, GA 30602, USADepartment of Poultry Science, University of Georgia, Athens, GA 30602, USACorresponding author:; Department of Poultry Science, University of Georgia, Athens, GA 30602, USAABSTRACT: Coccidiosis caused by Eimeria spp. results in substantial economic losses in the poultry industry. The objective of this study was to investigate the effects of dietary supplementation with n-3 polyunsaturated fatty acids-enriched fish oil on growth performance, intestinal barrier integrity, and intestinal immune response of broilers challenged with Eimeria spp. A total of 576 fourteen-day-old broilers were randomly assigned in a completely randomized design with a 3 × 2 factorial arrangement, comprising 2 diets supplemented with either 5% fish oil or 5% soybean oil, and 3 Eimeria spp. infection levels: a nonchallenge control, a low dose of Eimeria challenge, and a high challenge dose. The results of the study revealed significant interactions between diet and Eimeria challenge to parameters of gut barrier integrity and feed intake. A significant interaction was observed in feed intake between 5 and 8 d postinfection (DPI), where the fish oil groups exhibited a higher amount of feed intake compared to the soybean oil diet groups after coccidiosis infection. The effects of the fish oil diet resulted in enhanced gut barrier integrity, as evidenced by a trend of decreased gastrointestinal leakage and a lower mean of small intestine lesion scores after Eimeria challenge. Additionally, significant interactions were noted between Eimeria spp. challenge and diet regarding jejunal crypt depth. The positive impact of the fish oil diet was particularly noticeable with the high Eimeria challenge dose. Overall, these findings underscore the relationship between the fish oil diet and Eimeria challenge on broiler chicken intestinal health. Dietary supplementation of fish oil has the potential to maintain small intestine barrier integrity with severe Eimeria infection conditions.http://www.sciencedirect.com/science/article/pii/S0032579124002396fish oiln-3 PUFAcoccidiosisEimeriaintestinal integrity |
| spellingShingle | Yuguo Hou Tompkins Venkata Sesha Reddy Choppa Woo Kyun Kim n-3 enriched Fish oil diet enhanced intestinal barrier integrity in broilers after Eimeria infection Poultry Science fish oil n-3 PUFA coccidiosis Eimeria intestinal integrity |
| title | n-3 enriched Fish oil diet enhanced intestinal barrier integrity in broilers after Eimeria infection |
| title_full | n-3 enriched Fish oil diet enhanced intestinal barrier integrity in broilers after Eimeria infection |
| title_fullStr | n-3 enriched Fish oil diet enhanced intestinal barrier integrity in broilers after Eimeria infection |
| title_full_unstemmed | n-3 enriched Fish oil diet enhanced intestinal barrier integrity in broilers after Eimeria infection |
| title_short | n-3 enriched Fish oil diet enhanced intestinal barrier integrity in broilers after Eimeria infection |
| title_sort | n 3 enriched fish oil diet enhanced intestinal barrier integrity in broilers after eimeria infection |
| topic | fish oil n-3 PUFA coccidiosis Eimeria intestinal integrity |
| url | http://www.sciencedirect.com/science/article/pii/S0032579124002396 |
| work_keys_str_mv | AT yuguohoutompkins n3enrichedfishoildietenhancedintestinalbarrierintegrityinbroilersaftereimeriainfection AT venkataseshareddychoppa n3enrichedfishoildietenhancedintestinalbarrierintegrityinbroilersaftereimeriainfection AT wookyunkim n3enrichedfishoildietenhancedintestinalbarrierintegrityinbroilersaftereimeriainfection |