Antihyperlipidemic effect of bread fortified with potato peel powder against Triton X-100-induced hyperlipidemia in male albino rats
The present investigation aimed to improve the nutritional and healthy values and evaluate the influence of bread fortified with dried potato peels (BPP) on Triton X-100-induced hyperlipidemia in male albino rats. The findings demonstrated that BPP lowered hepatic triglycerides and total cholesterol...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623003250 |
| _version_ | 1797689009387864064 |
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| author | Osama I.A. Soltan Hanaa S.S. Gazwi Amany E. Ragab Magda E. Mahmoud Ferial M.N. Fudllalah Mesfer M. Alqahtani Abdulrahman Alasmari Hesham S. Ghazzawy Dalia M. Hikal |
| author_facet | Osama I.A. Soltan Hanaa S.S. Gazwi Amany E. Ragab Magda E. Mahmoud Ferial M.N. Fudllalah Mesfer M. Alqahtani Abdulrahman Alasmari Hesham S. Ghazzawy Dalia M. Hikal |
| author_sort | Osama I.A. Soltan |
| collection | DOAJ |
| description | The present investigation aimed to improve the nutritional and healthy values and evaluate the influence of bread fortified with dried potato peels (BPP) on Triton X-100-induced hyperlipidemia in male albino rats. The findings demonstrated that BPP lowered hepatic triglycerides and total cholesterol while increasing high-density lipoprotein (HDL-C). BPP exhibited potential lipid-lowering and hepatoprotective actions that were generated by the reduction of oxidative damage and preservation of the non-enzymatic and enzymatic antioxidant systems compromised by hyperlipidemic condition. Furthermore, BPP considerably enhanced the mRNA expression of AMPKα (AMP-activated protein kinase-alpha), suppressed the expression of fatty acid synthase (FAS) and acetyl-CoA carboxylase alpha (ACCα), and decreased the mRNA expression of the adipogenic transcription factor SREBP-1c (sterol regulatory element-binding protein-1c), which are essential regulators of hepatocyte lipid metabolism. A histopathological assessment of the liver confirmed the results. In conclusion, this investigation revealed a positive impact of bread fortified with BPP therapy in preventing hyperlipidemia. |
| first_indexed | 2024-03-12T01:38:44Z |
| format | Article |
| id | doaj.art-fceb6c4dfc484b72b150157442c5c208 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-12T01:38:44Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-fceb6c4dfc484b72b150157442c5c2082023-09-11T04:16:49ZengElsevierJournal of Functional Foods1756-46462023-09-01108105725Antihyperlipidemic effect of bread fortified with potato peel powder against Triton X-100-induced hyperlipidemia in male albino ratsOsama I.A. Soltan0Hanaa S.S. Gazwi1Amany E. Ragab2Magda E. Mahmoud3Ferial M.N. Fudllalah4Mesfer M. Alqahtani5Abdulrahman Alasmari6Hesham S. Ghazzawy7Dalia M. Hikal8Department of Food Science, Faculty of Agriculture, Minia University, El-Minia, EgyptDepartment of Agricultural Chemistry, Faculty of Agriculture, Minia University, El-Minia, Egypt; Corresponding author.Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta, EgyptDepartment of Agricultural Chemistry, Faculty of Agriculture, Minia University, El-Minia, EgyptDepartment of Biology, College of Science and Arts, Shaqra University, Sajer, Saudi ArabiaDepartment of Biological Sciences, Faculty of Science and Humanities, Shaqra University, P. O. Box 1040, Ad-Dawadimi 11911, Saudi ArabiaBiology Department, College of Science, Tabuk University, Tabuk 71491, Saudi ArabiaDate Palm Research Center of Excellence, King Faisal University, 12582, Saudi Arabia; Central Laboratory for Date Palm Research and Development, Agriculture Research Center, Giza 12511, EgyptNutrition and Food Science, Home Economics Department, Faculty of Specific Education, Sohag University, Sohag, EgyptThe present investigation aimed to improve the nutritional and healthy values and evaluate the influence of bread fortified with dried potato peels (BPP) on Triton X-100-induced hyperlipidemia in male albino rats. The findings demonstrated that BPP lowered hepatic triglycerides and total cholesterol while increasing high-density lipoprotein (HDL-C). BPP exhibited potential lipid-lowering and hepatoprotective actions that were generated by the reduction of oxidative damage and preservation of the non-enzymatic and enzymatic antioxidant systems compromised by hyperlipidemic condition. Furthermore, BPP considerably enhanced the mRNA expression of AMPKα (AMP-activated protein kinase-alpha), suppressed the expression of fatty acid synthase (FAS) and acetyl-CoA carboxylase alpha (ACCα), and decreased the mRNA expression of the adipogenic transcription factor SREBP-1c (sterol regulatory element-binding protein-1c), which are essential regulators of hepatocyte lipid metabolism. A histopathological assessment of the liver confirmed the results. In conclusion, this investigation revealed a positive impact of bread fortified with BPP therapy in preventing hyperlipidemia.http://www.sciencedirect.com/science/article/pii/S1756464623003250BreadPotato peelsTriton X-100AMPKα signaling pathway |
| spellingShingle | Osama I.A. Soltan Hanaa S.S. Gazwi Amany E. Ragab Magda E. Mahmoud Ferial M.N. Fudllalah Mesfer M. Alqahtani Abdulrahman Alasmari Hesham S. Ghazzawy Dalia M. Hikal Antihyperlipidemic effect of bread fortified with potato peel powder against Triton X-100-induced hyperlipidemia in male albino rats Journal of Functional Foods Bread Potato peels Triton X-100 AMPKα signaling pathway |
| title | Antihyperlipidemic effect of bread fortified with potato peel powder against Triton X-100-induced hyperlipidemia in male albino rats |
| title_full | Antihyperlipidemic effect of bread fortified with potato peel powder against Triton X-100-induced hyperlipidemia in male albino rats |
| title_fullStr | Antihyperlipidemic effect of bread fortified with potato peel powder against Triton X-100-induced hyperlipidemia in male albino rats |
| title_full_unstemmed | Antihyperlipidemic effect of bread fortified with potato peel powder against Triton X-100-induced hyperlipidemia in male albino rats |
| title_short | Antihyperlipidemic effect of bread fortified with potato peel powder against Triton X-100-induced hyperlipidemia in male albino rats |
| title_sort | antihyperlipidemic effect of bread fortified with potato peel powder against triton x 100 induced hyperlipidemia in male albino rats |
| topic | Bread Potato peels Triton X-100 AMPKα signaling pathway |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623003250 |
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