Critically Ill Patients with Renal Hyperfiltration: Optimizing Antibiotic Dose
Renal hyperfiltration (RHF) is a prevalent phenomenon in critically ill patients characterized by augmented renal clearance (ARC) and increased of elimination of renally eliminated medications. Multiple risk factors had been described and potential mechanisms may contribute to the occurrence of this...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
|
| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2023/6059079 |
| _version_ | 1797871903187140608 |
|---|---|
| author | Jorge Rico-Fontalvo José Correa-Guerrero María Cristina Martínez-Ávila Rodrigo Daza-Arnedo Tomás Rodriguez-Yanez Amilkar Almanza-Hurtado José Cabrales Carmen Julia Mendoza-Paternina Alvaro Frías-Salazar Julio Morales-Fernández |
| author_facet | Jorge Rico-Fontalvo José Correa-Guerrero María Cristina Martínez-Ávila Rodrigo Daza-Arnedo Tomás Rodriguez-Yanez Amilkar Almanza-Hurtado José Cabrales Carmen Julia Mendoza-Paternina Alvaro Frías-Salazar Julio Morales-Fernández |
| author_sort | Jorge Rico-Fontalvo |
| collection | DOAJ |
| description | Renal hyperfiltration (RHF) is a prevalent phenomenon in critically ill patients characterized by augmented renal clearance (ARC) and increased of elimination of renally eliminated medications. Multiple risk factors had been described and potential mechanisms may contribute to the occurrence of this condition. RHF and ARC are associated with the risk of suboptimal exposure to antibiotics increasing the risk of treatment failure and unfavorable patient outcomes. The current review discusses the available evidence related to the RHF phenomenon, including definition, epidemiology, risk factors, pathophysiology, pharmacokinetic variability, and considerations for optimizing the dosage of antibiotics in critically ill patients. |
| first_indexed | 2024-04-10T00:51:27Z |
| format | Article |
| id | doaj.art-fcf28bd0c6c64ed5a24d92bdd734719e |
| institution | Directory Open Access Journal |
| issn | 2090-2158 |
| language | English |
| last_indexed | 2024-04-10T00:51:27Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj.art-fcf28bd0c6c64ed5a24d92bdd734719e2023-03-13T11:25:31ZengHindawi LimitedInternational Journal of Nephrology2090-21582023-01-01202310.1155/2023/6059079Critically Ill Patients with Renal Hyperfiltration: Optimizing Antibiotic DoseJorge Rico-Fontalvo0José Correa-Guerrero1María Cristina Martínez-Ávila2Rodrigo Daza-Arnedo3Tomás Rodriguez-Yanez4Amilkar Almanza-Hurtado5José Cabrales6Carmen Julia Mendoza-Paternina7Alvaro Frías-Salazar8Julio Morales-Fernández9Colombian Association of Nephrology and HypertensionIntensive Care Unit Universidad de CartagenaEpidemiology and Public HealthColombian Association of Nephrology and HypertensionIntensive Care Unit Universidad de CartagenaIntensive Care Unit Universidad de CartagenaDivision of NephrologyDepartment of MedicineIntensive Care Unit Sanatorio Otamendi y Miroli Buenos AiresIntensive Care Unit Sanatorio Otamendi y Miroli Buenos AiresRenal hyperfiltration (RHF) is a prevalent phenomenon in critically ill patients characterized by augmented renal clearance (ARC) and increased of elimination of renally eliminated medications. Multiple risk factors had been described and potential mechanisms may contribute to the occurrence of this condition. RHF and ARC are associated with the risk of suboptimal exposure to antibiotics increasing the risk of treatment failure and unfavorable patient outcomes. The current review discusses the available evidence related to the RHF phenomenon, including definition, epidemiology, risk factors, pathophysiology, pharmacokinetic variability, and considerations for optimizing the dosage of antibiotics in critically ill patients.http://dx.doi.org/10.1155/2023/6059079 |
| spellingShingle | Jorge Rico-Fontalvo José Correa-Guerrero María Cristina Martínez-Ávila Rodrigo Daza-Arnedo Tomás Rodriguez-Yanez Amilkar Almanza-Hurtado José Cabrales Carmen Julia Mendoza-Paternina Alvaro Frías-Salazar Julio Morales-Fernández Critically Ill Patients with Renal Hyperfiltration: Optimizing Antibiotic Dose International Journal of Nephrology |
| title | Critically Ill Patients with Renal Hyperfiltration: Optimizing Antibiotic Dose |
| title_full | Critically Ill Patients with Renal Hyperfiltration: Optimizing Antibiotic Dose |
| title_fullStr | Critically Ill Patients with Renal Hyperfiltration: Optimizing Antibiotic Dose |
| title_full_unstemmed | Critically Ill Patients with Renal Hyperfiltration: Optimizing Antibiotic Dose |
| title_short | Critically Ill Patients with Renal Hyperfiltration: Optimizing Antibiotic Dose |
| title_sort | critically ill patients with renal hyperfiltration optimizing antibiotic dose |
| url | http://dx.doi.org/10.1155/2023/6059079 |
| work_keys_str_mv | AT jorgericofontalvo criticallyillpatientswithrenalhyperfiltrationoptimizingantibioticdose AT josecorreaguerrero criticallyillpatientswithrenalhyperfiltrationoptimizingantibioticdose AT mariacristinamartinezavila criticallyillpatientswithrenalhyperfiltrationoptimizingantibioticdose AT rodrigodazaarnedo criticallyillpatientswithrenalhyperfiltrationoptimizingantibioticdose AT tomasrodriguezyanez criticallyillpatientswithrenalhyperfiltrationoptimizingantibioticdose AT amilkaralmanzahurtado criticallyillpatientswithrenalhyperfiltrationoptimizingantibioticdose AT josecabrales criticallyillpatientswithrenalhyperfiltrationoptimizingantibioticdose AT carmenjuliamendozapaternina criticallyillpatientswithrenalhyperfiltrationoptimizingantibioticdose AT alvarofriassalazar criticallyillpatientswithrenalhyperfiltrationoptimizingantibioticdose AT juliomoralesfernandez criticallyillpatientswithrenalhyperfiltrationoptimizingantibioticdose |