Retrospective Evaluation of Various Serological Assays and Multiple Parameters for Optimal Diagnosis of Lyme Neuroborreliosis in a Routine Clinical Setting

Retrospective Evaluation of Various Serological Assays and Multiple Parameters for Optimal Diagnosis of Lyme Neuroborreliosis in a Routine Clinical Setting

ABSTRACT Laboratory diagnosis of Lyme neuroborreliosis (LNB) is challenging, and validated diagnostic algorithms are lacking. Therefore, this retrospective cross-sectional study aimed to compare the diagnostic performance of seven commercial antibody assays for LNB diagnosis. Random forest (RF) mode...

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Bibliographic Details
Main Authors: Tamara van Gorkom, Willem Voet, Gijs H. J. van Arkel, Michiel Heron, B. J. A. Hoeve-Bakker, Daan W. Notermans, Steven F. T. Thijsen, Kristin Kremer
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:Microbiology Spectrum
Subjects:
Borrelia
Lyme neuroborreliosis
cerebrospinal fluid
intrathecal antibody synthesis
antibody index
two-tier serology
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00061-22

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