Emerging role of mesenchymal stem cells-derived extracellular vesicles in vascular dementia
Vascular dementia (VD) is a prevalent cognitive disorder among the elderly. Its pathological mechanism encompasses neuronal damage, synaptic dysfunction, vascular abnormalities, neuroinflammation, and oxidative stress, among others. In recent years, extracellular vesicles (EVs) derived from mesenchy...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-02-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1329357/full |
| _version_ | 1797321067136548864 |
|---|---|
| author | Ziying Liu Ziying Liu Lin Cheng Lin Cheng Lushun Zhang Lushun Zhang Chunxiao Shen Chunxiao Shen Shufei Wei Shufei Wei Liangliang Wang Liangliang Wang Yuemin Qiu Yuemin Qiu Chuan Li Chuan Li Yinyi Xiong Yinyi Xiong Xiaorong Zhang Xiaorong Zhang Xiaorong Zhang |
| author_facet | Ziying Liu Ziying Liu Lin Cheng Lin Cheng Lushun Zhang Lushun Zhang Chunxiao Shen Chunxiao Shen Shufei Wei Shufei Wei Liangliang Wang Liangliang Wang Yuemin Qiu Yuemin Qiu Chuan Li Chuan Li Yinyi Xiong Yinyi Xiong Xiaorong Zhang Xiaorong Zhang Xiaorong Zhang |
| author_sort | Ziying Liu |
| collection | DOAJ |
| description | Vascular dementia (VD) is a prevalent cognitive disorder among the elderly. Its pathological mechanism encompasses neuronal damage, synaptic dysfunction, vascular abnormalities, neuroinflammation, and oxidative stress, among others. In recent years, extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have garnered significant attention as an emerging therapeutic strategy. Current research indicates that MSC-derived extracellular vesicles (MSC-EVs) play a pivotal role in both the diagnosis and treatment of VD. Thus, this article delves into the recent advancements of MSC-EVs in VD, discussing the mechanisms by which EVs influence the pathophysiological processes of VD. These mechanisms form the theoretical foundation for their neuroprotective effect in VD treatment. Additionally, the article highlights the potential applications of EVs in VD diagnosis. In conclusion, MSC-EVs present a promising innovative treatment strategy for VD. With rigorous research and ongoing innovation, this concept can transition into practical clinical treatment, providing more effective options for VD patients. |
| first_indexed | 2024-03-08T04:52:11Z |
| format | Article |
| id | doaj.art-fcf868b51a564d83b6834dbdd6c914bf |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-08T04:52:11Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-fcf868b51a564d83b6834dbdd6c914bf2024-02-08T04:42:17ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652024-02-011610.3389/fnagi.2024.13293571329357Emerging role of mesenchymal stem cells-derived extracellular vesicles in vascular dementiaZiying Liu0Ziying Liu1Lin Cheng2Lin Cheng3Lushun Zhang4Lushun Zhang5Chunxiao Shen6Chunxiao Shen7Shufei Wei8Shufei Wei9Liangliang Wang10Liangliang Wang11Yuemin Qiu12Yuemin Qiu13Chuan Li14Chuan Li15Yinyi Xiong16Yinyi Xiong17Xiaorong Zhang18Xiaorong Zhang19Xiaorong Zhang20Department of Pathology, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, ChinaJiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, ChinaJiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, ChinaDepartment of Neurology, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, ChinaDepartment of Pathology, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, ChinaJiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, ChinaDepartment of Pathology, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, ChinaJiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, ChinaDepartment of Pathology, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, ChinaJiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, ChinaDepartment of Pathology, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, ChinaJiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, ChinaDepartment of Pathology, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, ChinaJiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, ChinaDepartment of Pathology, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, ChinaJiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, ChinaJiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, ChinaDepartment of Rehabilitation, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, ChinaDepartment of Pathology, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, ChinaJiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, ChinaCenter for Cognitive Science and Transdisciplinary Studies, Jiujiang University, Jiujiang, Jiangxi, ChinaVascular dementia (VD) is a prevalent cognitive disorder among the elderly. Its pathological mechanism encompasses neuronal damage, synaptic dysfunction, vascular abnormalities, neuroinflammation, and oxidative stress, among others. In recent years, extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have garnered significant attention as an emerging therapeutic strategy. Current research indicates that MSC-derived extracellular vesicles (MSC-EVs) play a pivotal role in both the diagnosis and treatment of VD. Thus, this article delves into the recent advancements of MSC-EVs in VD, discussing the mechanisms by which EVs influence the pathophysiological processes of VD. These mechanisms form the theoretical foundation for their neuroprotective effect in VD treatment. Additionally, the article highlights the potential applications of EVs in VD diagnosis. In conclusion, MSC-EVs present a promising innovative treatment strategy for VD. With rigorous research and ongoing innovation, this concept can transition into practical clinical treatment, providing more effective options for VD patients.https://www.frontiersin.org/articles/10.3389/fnagi.2024.1329357/fullvascular dementiaextracellular vesicles derived from mesenchymal stem cellspathophysiologyneuroinflammationdiagnosis and treatment |
| spellingShingle | Ziying Liu Ziying Liu Lin Cheng Lin Cheng Lushun Zhang Lushun Zhang Chunxiao Shen Chunxiao Shen Shufei Wei Shufei Wei Liangliang Wang Liangliang Wang Yuemin Qiu Yuemin Qiu Chuan Li Chuan Li Yinyi Xiong Yinyi Xiong Xiaorong Zhang Xiaorong Zhang Xiaorong Zhang Emerging role of mesenchymal stem cells-derived extracellular vesicles in vascular dementia Frontiers in Aging Neuroscience vascular dementia extracellular vesicles derived from mesenchymal stem cells pathophysiology neuroinflammation diagnosis and treatment |
| title | Emerging role of mesenchymal stem cells-derived extracellular vesicles in vascular dementia |
| title_full | Emerging role of mesenchymal stem cells-derived extracellular vesicles in vascular dementia |
| title_fullStr | Emerging role of mesenchymal stem cells-derived extracellular vesicles in vascular dementia |
| title_full_unstemmed | Emerging role of mesenchymal stem cells-derived extracellular vesicles in vascular dementia |
| title_short | Emerging role of mesenchymal stem cells-derived extracellular vesicles in vascular dementia |
| title_sort | emerging role of mesenchymal stem cells derived extracellular vesicles in vascular dementia |
| topic | vascular dementia extracellular vesicles derived from mesenchymal stem cells pathophysiology neuroinflammation diagnosis and treatment |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1329357/full |
| work_keys_str_mv | AT ziyingliu emergingroleofmesenchymalstemcellsderivedextracellularvesiclesinvasculardementia AT ziyingliu emergingroleofmesenchymalstemcellsderivedextracellularvesiclesinvasculardementia AT lincheng emergingroleofmesenchymalstemcellsderivedextracellularvesiclesinvasculardementia AT lincheng emergingroleofmesenchymalstemcellsderivedextracellularvesiclesinvasculardementia AT lushunzhang emergingroleofmesenchymalstemcellsderivedextracellularvesiclesinvasculardementia AT lushunzhang emergingroleofmesenchymalstemcellsderivedextracellularvesiclesinvasculardementia AT chunxiaoshen emergingroleofmesenchymalstemcellsderivedextracellularvesiclesinvasculardementia AT chunxiaoshen emergingroleofmesenchymalstemcellsderivedextracellularvesiclesinvasculardementia AT shufeiwei emergingroleofmesenchymalstemcellsderivedextracellularvesiclesinvasculardementia AT shufeiwei emergingroleofmesenchymalstemcellsderivedextracellularvesiclesinvasculardementia AT liangliangwang emergingroleofmesenchymalstemcellsderivedextracellularvesiclesinvasculardementia AT liangliangwang emergingroleofmesenchymalstemcellsderivedextracellularvesiclesinvasculardementia AT yueminqiu emergingroleofmesenchymalstemcellsderivedextracellularvesiclesinvasculardementia AT yueminqiu emergingroleofmesenchymalstemcellsderivedextracellularvesiclesinvasculardementia AT chuanli emergingroleofmesenchymalstemcellsderivedextracellularvesiclesinvasculardementia AT chuanli emergingroleofmesenchymalstemcellsderivedextracellularvesiclesinvasculardementia AT yinyixiong emergingroleofmesenchymalstemcellsderivedextracellularvesiclesinvasculardementia AT yinyixiong emergingroleofmesenchymalstemcellsderivedextracellularvesiclesinvasculardementia AT xiaorongzhang emergingroleofmesenchymalstemcellsderivedextracellularvesiclesinvasculardementia AT xiaorongzhang emergingroleofmesenchymalstemcellsderivedextracellularvesiclesinvasculardementia AT xiaorongzhang emergingroleofmesenchymalstemcellsderivedextracellularvesiclesinvasculardementia |