Non-Tuberculous Mycobacteria Interference with BCG-Current Controversies and Future Directions
The global tuberculosis (TB) epidemic caused by the bacterial pathogen <i>Mycobacterium tuberculosis</i> (<i>M.tb</i>) continues unabated. The <i>Mycobacterium bovis</i> bacillus Calmette–Guérin (BCG) vaccination is widely utilized worldwide to protect against inf...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/8/4/688 |
| _version_ | 1797547799982637056 |
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| author | Deepshikha Verma Edward D. Chan Diane J. Ordway |
| author_facet | Deepshikha Verma Edward D. Chan Diane J. Ordway |
| author_sort | Deepshikha Verma |
| collection | DOAJ |
| description | The global tuberculosis (TB) epidemic caused by the bacterial pathogen <i>Mycobacterium tuberculosis</i> (<i>M.tb</i>) continues unabated. The <i>Mycobacterium bovis</i> bacillus Calmette–Guérin (BCG) vaccination is widely utilized worldwide to protect against infection with <i>M.tb</i>. BCG vaccine protection against TB has had widely varying results for reasons that are not well understood. BCG vaccine interference by non-tuberculosis (NTM) mycobacterial species has been implicated as the potential cause of reduced BCG vaccine efficacy against <i>M.tb</i>. Ongoing efforts to develop new vaccines for TB requires a thorough understanding of the effect of NTM exposure on BCG vaccine efficacy, which may ultimately be a critical determinant of success. We reviewed the conflicting reports on whether NTM interferes with the BCG vaccine, potential explanations to help resolve the controversy, and strategies for developing better animal models. Further studies are needed to longitudinally track the effects of NTM exposure on BCG vaccine-induced host-protective anti-TB immunity. |
| first_indexed | 2024-03-10T14:49:22Z |
| format | Article |
| id | doaj.art-fcf947865ccc4d918ab0c7135cf1a1d6 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T14:49:22Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-fcf947865ccc4d918ab0c7135cf1a1d62023-11-20T21:07:27ZengMDPI AGVaccines2076-393X2020-11-018468810.3390/vaccines8040688Non-Tuberculous Mycobacteria Interference with BCG-Current Controversies and Future DirectionsDeepshikha Verma0Edward D. Chan1Diane J. Ordway2Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratory, Colorado State University, 1682 Campus Delivery, 200 West Lake Street, Fort Collins, CO 80523, USADepartment of Medicine, Rocky Mountain Regional Veterans Affairs Medical Center, Denver, CO 80523, USADepartment of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratory, Colorado State University, 1682 Campus Delivery, 200 West Lake Street, Fort Collins, CO 80523, USAThe global tuberculosis (TB) epidemic caused by the bacterial pathogen <i>Mycobacterium tuberculosis</i> (<i>M.tb</i>) continues unabated. The <i>Mycobacterium bovis</i> bacillus Calmette–Guérin (BCG) vaccination is widely utilized worldwide to protect against infection with <i>M.tb</i>. BCG vaccine protection against TB has had widely varying results for reasons that are not well understood. BCG vaccine interference by non-tuberculosis (NTM) mycobacterial species has been implicated as the potential cause of reduced BCG vaccine efficacy against <i>M.tb</i>. Ongoing efforts to develop new vaccines for TB requires a thorough understanding of the effect of NTM exposure on BCG vaccine efficacy, which may ultimately be a critical determinant of success. We reviewed the conflicting reports on whether NTM interferes with the BCG vaccine, potential explanations to help resolve the controversy, and strategies for developing better animal models. Further studies are needed to longitudinally track the effects of NTM exposure on BCG vaccine-induced host-protective anti-TB immunity.https://www.mdpi.com/2076-393X/8/4/688<i>Mycobacterium tuberculosis</i>non-tuberculosis mycobacteriaBacille Calmette-Guérin |
| spellingShingle | Deepshikha Verma Edward D. Chan Diane J. Ordway Non-Tuberculous Mycobacteria Interference with BCG-Current Controversies and Future Directions Vaccines <i>Mycobacterium tuberculosis</i> non-tuberculosis mycobacteria Bacille Calmette-Guérin |
| title | Non-Tuberculous Mycobacteria Interference with BCG-Current Controversies and Future Directions |
| title_full | Non-Tuberculous Mycobacteria Interference with BCG-Current Controversies and Future Directions |
| title_fullStr | Non-Tuberculous Mycobacteria Interference with BCG-Current Controversies and Future Directions |
| title_full_unstemmed | Non-Tuberculous Mycobacteria Interference with BCG-Current Controversies and Future Directions |
| title_short | Non-Tuberculous Mycobacteria Interference with BCG-Current Controversies and Future Directions |
| title_sort | non tuberculous mycobacteria interference with bcg current controversies and future directions |
| topic | <i>Mycobacterium tuberculosis</i> non-tuberculosis mycobacteria Bacille Calmette-Guérin |
| url | https://www.mdpi.com/2076-393X/8/4/688 |
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