Associations between sarcopenia and white matter alterations in older adults with diabetes mellitus: A diffusion tensor imaging study
Abstract Aims/Introduction Older adults with diabetes mellitus are susceptible to sarcopenia. Diffusion tensor imaging studies have also shown that patients with diabetes have altered white matter integrity. However, the relationship between these structural changes in white matter and sarcopenia re...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-04-01
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| Series: | Journal of Diabetes Investigation |
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| Online Access: | https://doi.org/10.1111/jdi.13379 |
| _version_ | 1818676255762939904 |
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| author | Yoshiaki Tamura Keigo Shimoji Joji Ishikawa Aya Tachibana Remi Kodera Kazuhito Oba Kenji Toyoshima Yuko Chiba Aya M Tokumaru Atsushi Araki |
| author_facet | Yoshiaki Tamura Keigo Shimoji Joji Ishikawa Aya Tachibana Remi Kodera Kazuhito Oba Kenji Toyoshima Yuko Chiba Aya M Tokumaru Atsushi Araki |
| author_sort | Yoshiaki Tamura |
| collection | DOAJ |
| description | Abstract Aims/Introduction Older adults with diabetes mellitus are susceptible to sarcopenia. Diffusion tensor imaging studies have also shown that patients with diabetes have altered white matter integrity. However, the relationship between these structural changes in white matter and sarcopenia remains poorly understood. Materials and Methods The study included 284 older patients (aged ≥65 years) who visited the Tokyo Metropolitan Geriatric Hospital Frailty Clinic. We used diffusion tensor imaging to measure fractional anisotropy (FA) and mean diffusivity (MD) to evaluate changes in white matter integrity. We investigated the associations between sarcopenia, or its diagnostic components, and FA or MD in seven white matter tracts considered to be associated with sarcopenia according to the patients’ diabetes status. Results We found significantly low FA or high MD values in the bilateral anterior thalamic radiations (ATR) and right inferior fronto‐occipital fasciculus (IFOF) of patients with Asian Working Group for Sarcopenia 2019‐defined sarcopenia, in all patients and those with diabetes. Using binominal regression analyses, we associated low FA values in the left ATR and right IFOF with sarcopenia in all patients and those with diabetes, after adjusting for age, gender, HbA1c, blood pressure, cognitive function, physical activity, depression, nutritional status, and inflammation. Conclusions White matter alterations in left ATR and right IFOF are associated with the prevalence of sarcopenia in patients with diabetes. Specific changes to the left ATR and right IFOF tracts could play critical roles in the occurrence of sarcopenia in patients with diabetes. |
| first_indexed | 2024-12-17T08:40:34Z |
| format | Article |
| id | doaj.art-fcf9ce04e7844a389c0d2dc59abc2c94 |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-12-17T08:40:34Z |
| publishDate | 2021-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-fcf9ce04e7844a389c0d2dc59abc2c942022-12-21T21:56:22ZengWileyJournal of Diabetes Investigation2040-11162040-11242021-04-0112463364010.1111/jdi.13379Associations between sarcopenia and white matter alterations in older adults with diabetes mellitus: A diffusion tensor imaging studyYoshiaki Tamura0Keigo Shimoji1Joji Ishikawa2Aya Tachibana3Remi Kodera4Kazuhito Oba5Kenji Toyoshima6Yuko Chiba7Aya M Tokumaru8Atsushi Araki9Department of Diabetes, Metabolism, and Endocrinology Tokyo Metropolitan Geriatric Hospital Tokyo JapanDepartment of Diagnostic Radiology Tokyo Metropolitan Geriatric Hospital Tokyo JapanDepartment of Cardiology Tokyo Metropolitan Geriatric Hospital Tokyo JapanDepartment of Diabetes, Metabolism, and Endocrinology Tokyo Metropolitan Geriatric Hospital Tokyo JapanDepartment of Diabetes, Metabolism, and Endocrinology Tokyo Metropolitan Geriatric Hospital Tokyo JapanDepartment of Diabetes, Metabolism, and Endocrinology Tokyo Metropolitan Geriatric Hospital Tokyo JapanDepartment of Diabetes, Metabolism, and Endocrinology Tokyo Metropolitan Geriatric Hospital Tokyo JapanDepartment of Diabetes, Metabolism, and Endocrinology Tokyo Metropolitan Geriatric Hospital Tokyo JapanDepartment of Diagnostic Radiology Tokyo Metropolitan Geriatric Hospital Tokyo JapanDepartment of Diabetes, Metabolism, and Endocrinology Tokyo Metropolitan Geriatric Hospital Tokyo JapanAbstract Aims/Introduction Older adults with diabetes mellitus are susceptible to sarcopenia. Diffusion tensor imaging studies have also shown that patients with diabetes have altered white matter integrity. However, the relationship between these structural changes in white matter and sarcopenia remains poorly understood. Materials and Methods The study included 284 older patients (aged ≥65 years) who visited the Tokyo Metropolitan Geriatric Hospital Frailty Clinic. We used diffusion tensor imaging to measure fractional anisotropy (FA) and mean diffusivity (MD) to evaluate changes in white matter integrity. We investigated the associations between sarcopenia, or its diagnostic components, and FA or MD in seven white matter tracts considered to be associated with sarcopenia according to the patients’ diabetes status. Results We found significantly low FA or high MD values in the bilateral anterior thalamic radiations (ATR) and right inferior fronto‐occipital fasciculus (IFOF) of patients with Asian Working Group for Sarcopenia 2019‐defined sarcopenia, in all patients and those with diabetes. Using binominal regression analyses, we associated low FA values in the left ATR and right IFOF with sarcopenia in all patients and those with diabetes, after adjusting for age, gender, HbA1c, blood pressure, cognitive function, physical activity, depression, nutritional status, and inflammation. Conclusions White matter alterations in left ATR and right IFOF are associated with the prevalence of sarcopenia in patients with diabetes. Specific changes to the left ATR and right IFOF tracts could play critical roles in the occurrence of sarcopenia in patients with diabetes.https://doi.org/10.1111/jdi.13379Diabetes mellitusDiffusion tensor imagingSarcopenia |
| spellingShingle | Yoshiaki Tamura Keigo Shimoji Joji Ishikawa Aya Tachibana Remi Kodera Kazuhito Oba Kenji Toyoshima Yuko Chiba Aya M Tokumaru Atsushi Araki Associations between sarcopenia and white matter alterations in older adults with diabetes mellitus: A diffusion tensor imaging study Journal of Diabetes Investigation Diabetes mellitus Diffusion tensor imaging Sarcopenia |
| title | Associations between sarcopenia and white matter alterations in older adults with diabetes mellitus: A diffusion tensor imaging study |
| title_full | Associations between sarcopenia and white matter alterations in older adults with diabetes mellitus: A diffusion tensor imaging study |
| title_fullStr | Associations between sarcopenia and white matter alterations in older adults with diabetes mellitus: A diffusion tensor imaging study |
| title_full_unstemmed | Associations between sarcopenia and white matter alterations in older adults with diabetes mellitus: A diffusion tensor imaging study |
| title_short | Associations between sarcopenia and white matter alterations in older adults with diabetes mellitus: A diffusion tensor imaging study |
| title_sort | associations between sarcopenia and white matter alterations in older adults with diabetes mellitus a diffusion tensor imaging study |
| topic | Diabetes mellitus Diffusion tensor imaging Sarcopenia |
| url | https://doi.org/10.1111/jdi.13379 |
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