NREM delta power and AD-relevant tauopathy are associated with shared cortical gene networks
Abstract Reduced NREM sleep in humans is associated with AD neuropathology. Recent work has demonstrated a reduction in NREM sleep in preclinical AD, pointing to its potential utility as an early marker of dementia. We test the hypothesis that reduced NREM delta power and increased tauopathy are ass...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-86255-6 |
| _version_ | 1818432096603996160 |
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| author | Joseph R. Scarpa Peng Jiang Vance D. Gao Martha H. Vitaterna Fred W. Turek Andrew Kasarskis |
| author_facet | Joseph R. Scarpa Peng Jiang Vance D. Gao Martha H. Vitaterna Fred W. Turek Andrew Kasarskis |
| author_sort | Joseph R. Scarpa |
| collection | DOAJ |
| description | Abstract Reduced NREM sleep in humans is associated with AD neuropathology. Recent work has demonstrated a reduction in NREM sleep in preclinical AD, pointing to its potential utility as an early marker of dementia. We test the hypothesis that reduced NREM delta power and increased tauopathy are associated with shared underlying cortical molecular networks in preclinical AD. We integrate multi-omics data from two extensive public resources, a human Alzheimer’s disease cohort from the Mount Sinai Brain Bank (N = 125) reflecting AD progression and a (C57BL/6J × 129S1/SvImJ) F2 mouse population in which NREM delta power was measured (N = 98). Two cortical gene networks, including a CLOCK-dependent circadian network, are associated with NREM delta power and AD tauopathy progression. These networks were validated in independent mouse and human cohorts. Identifying gene networks related to preclinical AD elucidate possible mechanisms associated with the early disease phase and potential targets to alter the disease course. |
| first_indexed | 2024-12-14T15:59:46Z |
| format | Article |
| id | doaj.art-fcfae50e25be41e6bc8196f655c447ac |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T15:59:46Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-fcfae50e25be41e6bc8196f655c447ac2022-12-21T22:55:13ZengNature PortfolioScientific Reports2045-23222021-04-0111111110.1038/s41598-021-86255-6NREM delta power and AD-relevant tauopathy are associated with shared cortical gene networksJoseph R. Scarpa0Peng Jiang1Vance D. Gao2Martha H. Vitaterna3Fred W. Turek4Andrew Kasarskis5Department of Anesthesiology, Weill Cornell MedicineCenter for Sleep and Circadian Biology, Department of Neurobiology, Northwestern UniversityCenter for Sleep and Circadian Biology, Department of Neurobiology, Northwestern UniversityCenter for Sleep and Circadian Biology, Department of Neurobiology, Northwestern UniversityCenter for Sleep and Circadian Biology, Department of Neurobiology, Northwestern UniversityIcahn Institute for Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount SinaiAbstract Reduced NREM sleep in humans is associated with AD neuropathology. Recent work has demonstrated a reduction in NREM sleep in preclinical AD, pointing to its potential utility as an early marker of dementia. We test the hypothesis that reduced NREM delta power and increased tauopathy are associated with shared underlying cortical molecular networks in preclinical AD. We integrate multi-omics data from two extensive public resources, a human Alzheimer’s disease cohort from the Mount Sinai Brain Bank (N = 125) reflecting AD progression and a (C57BL/6J × 129S1/SvImJ) F2 mouse population in which NREM delta power was measured (N = 98). Two cortical gene networks, including a CLOCK-dependent circadian network, are associated with NREM delta power and AD tauopathy progression. These networks were validated in independent mouse and human cohorts. Identifying gene networks related to preclinical AD elucidate possible mechanisms associated with the early disease phase and potential targets to alter the disease course.https://doi.org/10.1038/s41598-021-86255-6 |
| spellingShingle | Joseph R. Scarpa Peng Jiang Vance D. Gao Martha H. Vitaterna Fred W. Turek Andrew Kasarskis NREM delta power and AD-relevant tauopathy are associated with shared cortical gene networks Scientific Reports |
| title | NREM delta power and AD-relevant tauopathy are associated with shared cortical gene networks |
| title_full | NREM delta power and AD-relevant tauopathy are associated with shared cortical gene networks |
| title_fullStr | NREM delta power and AD-relevant tauopathy are associated with shared cortical gene networks |
| title_full_unstemmed | NREM delta power and AD-relevant tauopathy are associated with shared cortical gene networks |
| title_short | NREM delta power and AD-relevant tauopathy are associated with shared cortical gene networks |
| title_sort | nrem delta power and ad relevant tauopathy are associated with shared cortical gene networks |
| url | https://doi.org/10.1038/s41598-021-86255-6 |
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