Serum neprilysin levels are elevated in preeclampsia
Objective: To evaluate the possible associations between serum Neprilysin (NEP) levels and preeclampsia and mild and severe preeclampsia subgroups. Materials and methods: Fifty-five consecutive women with mild preeclampsia and fifty-five consecutive women with severe preeclampsia were compared with...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S102845592100187X |
| _version_ | 1819124288391741440 |
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| author | Nevin Tüten Eduard Malik Koray Gök Kübra Hamzaoglu Melike Makul Yahya Özgün Öner Huri Bulut Abdullah Tüten Onur Güralp |
| author_facet | Nevin Tüten Eduard Malik Koray Gök Kübra Hamzaoglu Melike Makul Yahya Özgün Öner Huri Bulut Abdullah Tüten Onur Güralp |
| author_sort | Nevin Tüten |
| collection | DOAJ |
| description | Objective: To evaluate the possible associations between serum Neprilysin (NEP) levels and preeclampsia and mild and severe preeclampsia subgroups. Materials and methods: Fifty-five consecutive women with mild preeclampsia and fifty-five consecutive women with severe preeclampsia were compared with 110 approximately gestational age-matched (±1 week) women with an uncomplicated pregnancy. Results: Mean serum NEP was significantly higher in women with preeclampsia compared to that of the gestational age-matched-controls (231.62 ± 65.30 pg/mL vs. 187.75 ± 84.38 pg/mL, p < 0.001). Mean serum NEP was significantly higher in the mild preeclampsia group compared to its gestational age-matched control group (228.84 ± 67.26 pg/mL vs. 186.14 ± 85.09 pg/mL, p = 0.008); and in the severe preeclampsia group compared to its gestational age-matched control group (234.45 ± 63.85 pg/mL vs. 189.29 ± 84.59 pg/mL, p = 0.004). Serum NEP was positively correlated with systolic and diastolic blood pressure, BUN, uric acid, and creatinine. Conclusion: Mean serum NEP was significantly higher in women with preeclampsia than women with an uncomplicated pregnancy. Further studies are needed to elucidate the possible therapeutic role of NEP inhibitors to treat preeclampsia. |
| first_indexed | 2024-12-22T07:21:52Z |
| format | Article |
| id | doaj.art-fcfc12a7be2742b281e9b0d2ed182c15 |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-12-22T07:21:52Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-fcfc12a7be2742b281e9b0d2ed182c152022-12-21T18:34:15ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592021-09-01605869873Serum neprilysin levels are elevated in preeclampsiaNevin Tüten0Eduard Malik1Koray Gök2Kübra Hamzaoglu3Melike Makul4Yahya Özgün Öner5Huri Bulut6Abdullah Tüten7Onur Güralp8Kanuni Sultan Suleyman Education and Research Hospital, Obstetrics and Gynecology Istanbul, TurkeyCarl von Ossietzky Oldenburg University, University Hospital for Gynecology and Obstetrics, Klinikum Oldenburg AöR, Oldenburg, GermanySakarya University, Education and Research Hospital, Obstetrics and Gynecology, Sakarya, TurkeyIstanbul Cerrahpasa University, Department of Obstetrics and Gynecology, Istanbul, TurkeyIstanbul Cerrahpasa University, Department of Obstetrics and Gynecology, Istanbul, TurkeyIstanbul Cerrahpasa University, Department of Obstetrics and Gynecology, Istanbul, TurkeyIstinye University, Faculty of Medicine, Medical Biochemistry Department, Istanbul, TurkeyIstanbul Cerrahpasa University, Department of Obstetrics and Gynecology, Istanbul, Turkey; Corresponding author. Department of Obstetrics and Gynecology, Cerrahpasa Medical Faculty Istanbul University-Cerrahpaşa, Kocamustafapasa Street, No:53, Cerrahpasa, 34098, Fatih, Istanbul, Turkey.Carl von Ossietzky Oldenburg University, University Hospital for Gynecology and Obstetrics, Klinikum Oldenburg AöR, Oldenburg, GermanyObjective: To evaluate the possible associations between serum Neprilysin (NEP) levels and preeclampsia and mild and severe preeclampsia subgroups. Materials and methods: Fifty-five consecutive women with mild preeclampsia and fifty-five consecutive women with severe preeclampsia were compared with 110 approximately gestational age-matched (±1 week) women with an uncomplicated pregnancy. Results: Mean serum NEP was significantly higher in women with preeclampsia compared to that of the gestational age-matched-controls (231.62 ± 65.30 pg/mL vs. 187.75 ± 84.38 pg/mL, p < 0.001). Mean serum NEP was significantly higher in the mild preeclampsia group compared to its gestational age-matched control group (228.84 ± 67.26 pg/mL vs. 186.14 ± 85.09 pg/mL, p = 0.008); and in the severe preeclampsia group compared to its gestational age-matched control group (234.45 ± 63.85 pg/mL vs. 189.29 ± 84.59 pg/mL, p = 0.004). Serum NEP was positively correlated with systolic and diastolic blood pressure, BUN, uric acid, and creatinine. Conclusion: Mean serum NEP was significantly higher in women with preeclampsia than women with an uncomplicated pregnancy. Further studies are needed to elucidate the possible therapeutic role of NEP inhibitors to treat preeclampsia.http://www.sciencedirect.com/science/article/pii/S102845592100187XBlood pressureEnkephalinaseEndopeptidaseNatriuretic peptidesNeutral endopeptidase |
| spellingShingle | Nevin Tüten Eduard Malik Koray Gök Kübra Hamzaoglu Melike Makul Yahya Özgün Öner Huri Bulut Abdullah Tüten Onur Güralp Serum neprilysin levels are elevated in preeclampsia Taiwanese Journal of Obstetrics & Gynecology Blood pressure Enkephalinase Endopeptidase Natriuretic peptides Neutral endopeptidase |
| title | Serum neprilysin levels are elevated in preeclampsia |
| title_full | Serum neprilysin levels are elevated in preeclampsia |
| title_fullStr | Serum neprilysin levels are elevated in preeclampsia |
| title_full_unstemmed | Serum neprilysin levels are elevated in preeclampsia |
| title_short | Serum neprilysin levels are elevated in preeclampsia |
| title_sort | serum neprilysin levels are elevated in preeclampsia |
| topic | Blood pressure Enkephalinase Endopeptidase Natriuretic peptides Neutral endopeptidase |
| url | http://www.sciencedirect.com/science/article/pii/S102845592100187X |
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