New evidence of the presence of micro- and nanoplastic particles in bronchioalveolar lavage samples of clinical trial subjects
This is the first study reporting the presence of airborne nano-sized plastic particles in the bronchoalveolar lavage fluid (BALF) samples of patients undergoing diagnostic bronchoscopy. The results represent the plastic pollution content in the lower airways of the residents of Northern Europe. Air...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023068731 |
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| author | Ieva Uogintė Agnė Vailionytė Martynas Skapas Dave Bolanos Ernesta Bagurskienė Vygantas Gruslys Rūta Aldonytė Steigvilė Byčenkienė |
| author_facet | Ieva Uogintė Agnė Vailionytė Martynas Skapas Dave Bolanos Ernesta Bagurskienė Vygantas Gruslys Rūta Aldonytė Steigvilė Byčenkienė |
| author_sort | Ieva Uogintė |
| collection | DOAJ |
| description | This is the first study reporting the presence of airborne nano-sized plastic particles in the bronchoalveolar lavage fluid (BALF) samples of patients undergoing diagnostic bronchoscopy. The results represent the plastic pollution content in the lower airways of the residents of Northern Europe. Airborne micro- and nanoplastic particles (MP/NPs) are widely dispersed worldwide and intrude on human organisms to various extents, with the respiratory tract being the first line of exposure. The amounts of inhaled MP/NPs, their fate in the human respiratory tract, and the effects on the health of human airways and other exposed organs remain largely unknown.In this clinical study, human BALF samples were assessed by means of optical and transmission electron microscopy coupled with energy-dispersive X-ray spectroscopy (TEM-EDX). Results show that MP/NPs levels vary in the interval of 0.14–12.8 particles per 100 ml of BALF and are present in all samples tested, mainly in a fragmented form. External pollution by MP/NPs was excluded by carefully choosing methodology and equipment. This finding is a timely addition of valuable information and stimulates further research into the biological effects of inhaled MP/NPs. |
| first_indexed | 2024-03-11T20:51:09Z |
| format | Article |
| id | doaj.art-fcfc218c41cb47589b75b8f0134ba3fd |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-11T20:51:09Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-fcfc218c41cb47589b75b8f0134ba3fd2023-10-01T06:00:47ZengElsevierHeliyon2405-84402023-09-0199e19665New evidence of the presence of micro- and nanoplastic particles in bronchioalveolar lavage samples of clinical trial subjectsIeva Uogintė0Agnė Vailionytė1Martynas Skapas2Dave Bolanos3Ernesta Bagurskienė4Vygantas Gruslys5Rūta Aldonytė6Steigvilė Byčenkienė7State Research Institute Center for Physical Sciences and Technology (FTMC), Vilnius, LithuaniaState Research Institute Center for Innovative Medicine, Vilnius, Lithuania; Corresponding author. Dept. of Regenerative Medicine, State Research Institute Center for Innovative Medicine, Santariskiu 5, Vilnius, Lithuania.State Research Institute Center for Physical Sciences and Technology (FTMC), Vilnius, LithuaniaState Research Institute Center for Innovative Medicine, Vilnius, LithuaniaVilnius University Hospital Santaros Clinics, Interventional Pulmonology and Lung Function Diagnostics Department, Vilnius, LithuaniaVilnius University Hospital Santaros Clinics, Interventional Pulmonology and Lung Function Diagnostics Department, Vilnius, LithuaniaState Research Institute Center for Innovative Medicine, Vilnius, LithuaniaState Research Institute Center for Physical Sciences and Technology (FTMC), Vilnius, LithuaniaThis is the first study reporting the presence of airborne nano-sized plastic particles in the bronchoalveolar lavage fluid (BALF) samples of patients undergoing diagnostic bronchoscopy. The results represent the plastic pollution content in the lower airways of the residents of Northern Europe. Airborne micro- and nanoplastic particles (MP/NPs) are widely dispersed worldwide and intrude on human organisms to various extents, with the respiratory tract being the first line of exposure. The amounts of inhaled MP/NPs, their fate in the human respiratory tract, and the effects on the health of human airways and other exposed organs remain largely unknown.In this clinical study, human BALF samples were assessed by means of optical and transmission electron microscopy coupled with energy-dispersive X-ray spectroscopy (TEM-EDX). Results show that MP/NPs levels vary in the interval of 0.14–12.8 particles per 100 ml of BALF and are present in all samples tested, mainly in a fragmented form. External pollution by MP/NPs was excluded by carefully choosing methodology and equipment. This finding is a timely addition of valuable information and stimulates further research into the biological effects of inhaled MP/NPs.http://www.sciencedirect.com/science/article/pii/S2405844023068731MicroplasticNanoplasticBronchoalveolar lavage fluidAir pollution |
| spellingShingle | Ieva Uogintė Agnė Vailionytė Martynas Skapas Dave Bolanos Ernesta Bagurskienė Vygantas Gruslys Rūta Aldonytė Steigvilė Byčenkienė New evidence of the presence of micro- and nanoplastic particles in bronchioalveolar lavage samples of clinical trial subjects Heliyon Microplastic Nanoplastic Bronchoalveolar lavage fluid Air pollution |
| title | New evidence of the presence of micro- and nanoplastic particles in bronchioalveolar lavage samples of clinical trial subjects |
| title_full | New evidence of the presence of micro- and nanoplastic particles in bronchioalveolar lavage samples of clinical trial subjects |
| title_fullStr | New evidence of the presence of micro- and nanoplastic particles in bronchioalveolar lavage samples of clinical trial subjects |
| title_full_unstemmed | New evidence of the presence of micro- and nanoplastic particles in bronchioalveolar lavage samples of clinical trial subjects |
| title_short | New evidence of the presence of micro- and nanoplastic particles in bronchioalveolar lavage samples of clinical trial subjects |
| title_sort | new evidence of the presence of micro and nanoplastic particles in bronchioalveolar lavage samples of clinical trial subjects |
| topic | Microplastic Nanoplastic Bronchoalveolar lavage fluid Air pollution |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023068731 |
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