New insights on stem cells modeling and treatment of human diseases
Stem cells exist in many niches throughout the body and have the ability to self replicate and to differentiate to many lineages. As of a result of the advances in stem cell-based therapies, regenerative medicine is witnessing remarkable development. Encouraging positive outcomes from the use of ste...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2020-03-01
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| Series: | Frontiers in Bioscience-Landmark |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/FBL/25/8/10.2741/4868 |
| _version_ | 1811306103048241152 |
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| author | Geeta Rai Doli Das Khushbu Priya |
| author_facet | Geeta Rai Doli Das Khushbu Priya |
| author_sort | Geeta Rai |
| collection | DOAJ |
| description | Stem cells exist in many niches throughout the body and have the ability to self replicate and to differentiate to many lineages. As of a result of the advances in stem cell-based therapies, regenerative medicine is witnessing remarkable development. Encouraging positive outcomes from the use of stem cells in various diseases are extremely promising.. The popularity of stem cell-based therapy is due to its flexibility and potent approach in the treatment of numerous diseases. Treatment with genetically configured HSCs favors the engraftment of transplantation without rejection. MSCs hold an immunoregulatory capacity, elicit immunosuppressive effects and are immune-privileged cells, due to the low expression of MHCII and costimulatory molecules on their cell surface. Encouraging, positive outcomes from the use of stem cells in immunodeficiency, cancer, hemoglobinopathy, bone, cartilage repair, autoimmune disorders, cardiac and neuronal diseases are extremely promising. Successful stem cells based clinical trials are the game changers in the progress of clinical use of stem cells. This review provides an up to date comprehensive overview of the clinical efficacy of stem cells. |
| first_indexed | 2024-04-13T08:38:25Z |
| format | Article |
| id | doaj.art-fcfe8cd0e704430db55460e5f62e0a5e |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-04-13T08:38:25Z |
| publishDate | 2020-03-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-fcfe8cd0e704430db55460e5f62e0a5e2022-12-22T02:54:02ZengIMR PressFrontiers in Bioscience-Landmark2768-67012020-03-012581568159910.2741/4868S2768-6701(21)00142-8New insights on stem cells modeling and treatment of human diseasesGeeta Rai0Doli Das1Khushbu Priya2Department of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi-221005, IndiaDepartment of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi-221005, IndiaDepartment of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi-221005, IndiaStem cells exist in many niches throughout the body and have the ability to self replicate and to differentiate to many lineages. As of a result of the advances in stem cell-based therapies, regenerative medicine is witnessing remarkable development. Encouraging positive outcomes from the use of stem cells in various diseases are extremely promising.. The popularity of stem cell-based therapy is due to its flexibility and potent approach in the treatment of numerous diseases. Treatment with genetically configured HSCs favors the engraftment of transplantation without rejection. MSCs hold an immunoregulatory capacity, elicit immunosuppressive effects and are immune-privileged cells, due to the low expression of MHCII and costimulatory molecules on their cell surface. Encouraging, positive outcomes from the use of stem cells in immunodeficiency, cancer, hemoglobinopathy, bone, cartilage repair, autoimmune disorders, cardiac and neuronal diseases are extremely promising. Successful stem cells based clinical trials are the game changers in the progress of clinical use of stem cells. This review provides an up to date comprehensive overview of the clinical efficacy of stem cells.https://www.imrpress.com/journal/FBL/25/8/10.2741/4868hematopoietic stem cellsmesenchymal stem cellsclinical trialstransplantationtherapyreview |
| spellingShingle | Geeta Rai Doli Das Khushbu Priya New insights on stem cells modeling and treatment of human diseases Frontiers in Bioscience-Landmark hematopoietic stem cells mesenchymal stem cells clinical trials transplantation therapy review |
| title | New insights on stem cells modeling and treatment of human diseases |
| title_full | New insights on stem cells modeling and treatment of human diseases |
| title_fullStr | New insights on stem cells modeling and treatment of human diseases |
| title_full_unstemmed | New insights on stem cells modeling and treatment of human diseases |
| title_short | New insights on stem cells modeling and treatment of human diseases |
| title_sort | new insights on stem cells modeling and treatment of human diseases |
| topic | hematopoietic stem cells mesenchymal stem cells clinical trials transplantation therapy review |
| url | https://www.imrpress.com/journal/FBL/25/8/10.2741/4868 |
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