Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice
The effects of Laminaria japonica fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated in this work. Results indicated that LF significantly enhanced the spleen and thymus indices, promoted spleen lymphocyte and peritoneal macrophages...
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| Format: | Article |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.916618/full |
| _version_ | 1811257843301482496 |
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| author | Yunping Tang Qiuyan Pu Qiaoling Zhao Yafeng Zhou Xiaoxia Jiang Tao Han |
| author_facet | Yunping Tang Qiuyan Pu Qiaoling Zhao Yafeng Zhou Xiaoxia Jiang Tao Han |
| author_sort | Yunping Tang |
| collection | DOAJ |
| description | The effects of Laminaria japonica fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated in this work. Results indicated that LF significantly enhanced the spleen and thymus indices, promoted spleen lymphocyte and peritoneal macrophages proliferation, and increased the immune-related cytokines production in serum. Moreover, LF could regulate intestinal flora composition, increasing the abundance of Lactobacillaceae and Alistipes, and inhibiting Erysipelotrichia, Turicibacter, Romboutsia, Peptostreptococcaceae, and Faecalibaculum. These results were positively correlated with immune characteristics. Overall, LF could be useful as a new potential strategy to mitigate CTX immunosuppression and intestinal microbiota disorders. |
| first_indexed | 2024-04-12T18:03:52Z |
| format | Article |
| id | doaj.art-fcfebc6e867d411d885d2f6a350d6e48 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T18:03:52Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-fcfebc6e867d411d885d2f6a350d6e482022-12-22T03:22:04ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-05-011310.3389/fimmu.2022.916618916618Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated MiceYunping Tang0Qiuyan Pu1Qiaoling Zhao2Yafeng Zhou3Xiaoxia Jiang4Tao Han5Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan, ChinaZhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan, ChinaZhoushan Institute for Food and Drug Control, Zhoushan, ChinaZhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan, ChinaZhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan, ChinaDepartment of Aquaculture, Zhejiang Ocean University, Zhoushan, ChinaThe effects of Laminaria japonica fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated in this work. Results indicated that LF significantly enhanced the spleen and thymus indices, promoted spleen lymphocyte and peritoneal macrophages proliferation, and increased the immune-related cytokines production in serum. Moreover, LF could regulate intestinal flora composition, increasing the abundance of Lactobacillaceae and Alistipes, and inhibiting Erysipelotrichia, Turicibacter, Romboutsia, Peptostreptococcaceae, and Faecalibaculum. These results were positively correlated with immune characteristics. Overall, LF could be useful as a new potential strategy to mitigate CTX immunosuppression and intestinal microbiota disorders.https://www.frontiersin.org/articles/10.3389/fimmu.2022.916618/fullfucoidancyclophosphamideimmunosuppressionimmunomodulatorygut microbiota |
| spellingShingle | Yunping Tang Qiuyan Pu Qiaoling Zhao Yafeng Zhou Xiaoxia Jiang Tao Han Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice Frontiers in Immunology fucoidan cyclophosphamide immunosuppression immunomodulatory gut microbiota |
| title | Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice |
| title_full | Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice |
| title_fullStr | Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice |
| title_full_unstemmed | Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice |
| title_short | Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice |
| title_sort | effects of fucoidan isolated from laminaria japonica on immune response and gut microbiota in cyclophosphamide treated mice |
| topic | fucoidan cyclophosphamide immunosuppression immunomodulatory gut microbiota |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.916618/full |
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