SH3 interactome conserves general function over specific form

SH3 interactome conserves general function over specific form

Abstract Src homology 3 (SH3) domains bind peptides to mediate protein–protein interactions that assemble and regulate dynamic biological processes. We surveyed the repertoire of SH3 binding specificity using peptide phage display in a metazoan, the worm Caenorhabditis elegans, and discovered that i...

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Bibliographic Details
Main Authors: Xiaofeng Xin, David Gfeller, Jackie Cheng, Raffi Tonikian, Lin Sun, Ailan Guo, Lianet Lopez, Alevtina Pavlenco, Adenrele Akintobi, Yingnan Zhang, Jean‐François Rual, Bridget Currell, Somasekar Seshagiri, Tong Hao, Xinping Yang, Yun A Shen, Kourosh Salehi‐Ashtiani, Jingjing Li, Aaron T Cheng, Dryden Bouamalay, Adrien Lugari, David E Hill, Mark L Grimes, David G Drubin, Barth D Grant, Marc Vidal, Charles Boone, Sachdev S Sidhu, Gary D Bader
Format: Article
Language:English
Published: Springer Nature 2013-04-01
Series:Molecular Systems Biology
Subjects:
network evolution
phage display
protein interaction conservation
SH3 domains
yeast two‐hybrid
Online Access:https://doi.org/10.1038/msb.2013.9

Internet

https://doi.org/10.1038/msb.2013.9

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