Injectables and Depots to Prolong Drug Action of Proteins and Peptides
Proteins and peptides have emerged in recent years to treat a wide range of multifaceted diseases such as cancer, diabetes and inflammation. The emergence of polypeptides has yielded advancements in the fields of biopharmaceutical production and formulation. Polypeptides often display poor pharmacok...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/12/10/999 |
| _version_ | 1797550286285307904 |
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| author | Nkiruka Ibeanu Raphael Egbu Lesley Onyekuru Hoda Javaheri Peng Tee Khaw Gareth R. Williams Steve Brocchini Sahar Awwad |
| author_facet | Nkiruka Ibeanu Raphael Egbu Lesley Onyekuru Hoda Javaheri Peng Tee Khaw Gareth R. Williams Steve Brocchini Sahar Awwad |
| author_sort | Nkiruka Ibeanu |
| collection | DOAJ |
| description | Proteins and peptides have emerged in recent years to treat a wide range of multifaceted diseases such as cancer, diabetes and inflammation. The emergence of polypeptides has yielded advancements in the fields of biopharmaceutical production and formulation. Polypeptides often display poor pharmacokinetics, limited permeability across biological barriers, suboptimal biodistribution, and some proclivity for immunogenicity. Frequent administration of polypeptides is generally required to maintain adequate therapeutic levels, which can limit efficacy and compliance while increasing adverse reactions. Many strategies to increase the duration of action of therapeutic polypeptides have been described with many clinical products having been developed. This review describes approaches to optimise polypeptide delivery organised by the commonly used routes of administration. Future innovations in formulation may hold the key to the continued successful development of proteins and peptides with optimal clinical properties. |
| first_indexed | 2024-03-10T15:27:08Z |
| format | Article |
| id | doaj.art-fcfff3951e084046acbebc214f2df601 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T15:27:08Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-fcfff3951e084046acbebc214f2df6012023-11-20T17:58:32ZengMDPI AGPharmaceutics1999-49232020-10-01121099910.3390/pharmaceutics12100999Injectables and Depots to Prolong Drug Action of Proteins and PeptidesNkiruka Ibeanu0Raphael Egbu1Lesley Onyekuru2Hoda Javaheri3Peng Tee Khaw4Gareth R. Williams5Steve Brocchini6Sahar Awwad7School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UKSchool of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UKSchool of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UKSchool of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UKNational Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London EC1V 9EL, UKSchool of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UKSchool of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UKSchool of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UKProteins and peptides have emerged in recent years to treat a wide range of multifaceted diseases such as cancer, diabetes and inflammation. The emergence of polypeptides has yielded advancements in the fields of biopharmaceutical production and formulation. Polypeptides often display poor pharmacokinetics, limited permeability across biological barriers, suboptimal biodistribution, and some proclivity for immunogenicity. Frequent administration of polypeptides is generally required to maintain adequate therapeutic levels, which can limit efficacy and compliance while increasing adverse reactions. Many strategies to increase the duration of action of therapeutic polypeptides have been described with many clinical products having been developed. This review describes approaches to optimise polypeptide delivery organised by the commonly used routes of administration. Future innovations in formulation may hold the key to the continued successful development of proteins and peptides with optimal clinical properties.https://www.mdpi.com/1999-4923/12/10/999half-lifedrug deliveryocularsubcutaneousintravenousoral |
| spellingShingle | Nkiruka Ibeanu Raphael Egbu Lesley Onyekuru Hoda Javaheri Peng Tee Khaw Gareth R. Williams Steve Brocchini Sahar Awwad Injectables and Depots to Prolong Drug Action of Proteins and Peptides Pharmaceutics half-life drug delivery ocular subcutaneous intravenous oral |
| title | Injectables and Depots to Prolong Drug Action of Proteins and Peptides |
| title_full | Injectables and Depots to Prolong Drug Action of Proteins and Peptides |
| title_fullStr | Injectables and Depots to Prolong Drug Action of Proteins and Peptides |
| title_full_unstemmed | Injectables and Depots to Prolong Drug Action of Proteins and Peptides |
| title_short | Injectables and Depots to Prolong Drug Action of Proteins and Peptides |
| title_sort | injectables and depots to prolong drug action of proteins and peptides |
| topic | half-life drug delivery ocular subcutaneous intravenous oral |
| url | https://www.mdpi.com/1999-4923/12/10/999 |
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