Ternary Cu(II) Complex with GHK Peptide and <i>Cis</i>-Urocanic Acid as a Potential Physiologically Functional Copper Chelate
The tripeptide NH<sub>2</sub>–Gly–His–Lys–COOH (GHK), <i>cis</i>-urocanic acid (<i>cis</i>-UCA) and Cu(II) ions are physiological constituents of the human body and they co-occur (e.g., in the skin and the plasma). While GHK is known as Cu(II)-binding molecule, we...
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MDPI AG
2020-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/17/6190 |
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| author | Karolina Bossak-Ahmad Marta D. Wiśniewska Wojciech Bal Simon C. Drew Tomasz Frączyk |
| author_facet | Karolina Bossak-Ahmad Marta D. Wiśniewska Wojciech Bal Simon C. Drew Tomasz Frączyk |
| author_sort | Karolina Bossak-Ahmad |
| collection | DOAJ |
| description | The tripeptide NH<sub>2</sub>–Gly–His–Lys–COOH (GHK), <i>cis</i>-urocanic acid (<i>cis</i>-UCA) and Cu(II) ions are physiological constituents of the human body and they co-occur (e.g., in the skin and the plasma). While GHK is known as Cu(II)-binding molecule, we found that urocanic acid also coordinates Cu(II) ions. Furthermore, both ligands create ternary Cu(II) complex being probably physiologically functional species. Regarding the natural concentrations of the studied molecules in some human tissues, together with the affinities reported here, we conclude that the ternary complex [GHK][Cu(II)][<i>cis</i>-urocanic acid] may be partly responsible for biological effects of GHK and urocanic acid described in the literature. |
| first_indexed | 2024-03-10T16:47:23Z |
| format | Article |
| id | doaj.art-fd00e00e841a4afa877c65da20b3174a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T16:47:23Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-fd00e00e841a4afa877c65da20b3174a2023-11-20T11:33:51ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-08-012117619010.3390/ijms21176190Ternary Cu(II) Complex with GHK Peptide and <i>Cis</i>-Urocanic Acid as a Potential Physiologically Functional Copper ChelateKarolina Bossak-Ahmad0Marta D. Wiśniewska1Wojciech Bal2Simon C. Drew3Tomasz Frączyk4Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5a, 02-106 Warsaw, PolandInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5a, 02-106 Warsaw, PolandInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5a, 02-106 Warsaw, PolandInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5a, 02-106 Warsaw, PolandInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5a, 02-106 Warsaw, PolandThe tripeptide NH<sub>2</sub>–Gly–His–Lys–COOH (GHK), <i>cis</i>-urocanic acid (<i>cis</i>-UCA) and Cu(II) ions are physiological constituents of the human body and they co-occur (e.g., in the skin and the plasma). While GHK is known as Cu(II)-binding molecule, we found that urocanic acid also coordinates Cu(II) ions. Furthermore, both ligands create ternary Cu(II) complex being probably physiologically functional species. Regarding the natural concentrations of the studied molecules in some human tissues, together with the affinities reported here, we conclude that the ternary complex [GHK][Cu(II)][<i>cis</i>-urocanic acid] may be partly responsible for biological effects of GHK and urocanic acid described in the literature.https://www.mdpi.com/1422-0067/21/17/6190copperternary compleximidazole ligands |
| spellingShingle | Karolina Bossak-Ahmad Marta D. Wiśniewska Wojciech Bal Simon C. Drew Tomasz Frączyk Ternary Cu(II) Complex with GHK Peptide and <i>Cis</i>-Urocanic Acid as a Potential Physiologically Functional Copper Chelate International Journal of Molecular Sciences copper ternary complex imidazole ligands |
| title | Ternary Cu(II) Complex with GHK Peptide and <i>Cis</i>-Urocanic Acid as a Potential Physiologically Functional Copper Chelate |
| title_full | Ternary Cu(II) Complex with GHK Peptide and <i>Cis</i>-Urocanic Acid as a Potential Physiologically Functional Copper Chelate |
| title_fullStr | Ternary Cu(II) Complex with GHK Peptide and <i>Cis</i>-Urocanic Acid as a Potential Physiologically Functional Copper Chelate |
| title_full_unstemmed | Ternary Cu(II) Complex with GHK Peptide and <i>Cis</i>-Urocanic Acid as a Potential Physiologically Functional Copper Chelate |
| title_short | Ternary Cu(II) Complex with GHK Peptide and <i>Cis</i>-Urocanic Acid as a Potential Physiologically Functional Copper Chelate |
| title_sort | ternary cu ii complex with ghk peptide and i cis i urocanic acid as a potential physiologically functional copper chelate |
| topic | copper ternary complex imidazole ligands |
| url | https://www.mdpi.com/1422-0067/21/17/6190 |
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