Extracellular Vesicles for Therapeutic Nucleic Acid Delivery: Loading Strategies and Challenges
Extracellular vesicles (EVs) are membrane vesicles released into the extracellular milieu by cells of various origins. They contain different biological cargoes, protecting them from degradation by environmental factors. There is an opinion that EVs have a number of advantages over synthetic carrier...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/8/7287 |
| _version_ | 1797605122063204352 |
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| author | Anastasiya Oshchepkova Marina Zenkova Valentin Vlassov |
| author_facet | Anastasiya Oshchepkova Marina Zenkova Valentin Vlassov |
| author_sort | Anastasiya Oshchepkova |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) are membrane vesicles released into the extracellular milieu by cells of various origins. They contain different biological cargoes, protecting them from degradation by environmental factors. There is an opinion that EVs have a number of advantages over synthetic carriers, creating new opportunities for drug delivery. In this review, we discuss the ability of EVs to function as carriers for therapeutic nucleic acids (tNAs), challenges associated with the use of such carriers in vivo, and various strategies for tNA loading into EVs. |
| first_indexed | 2024-03-11T04:56:40Z |
| format | Article |
| id | doaj.art-fd01db7f70bd4cf8ad743696cfdd2cd7 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:56:40Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-fd01db7f70bd4cf8ad743696cfdd2cd72023-11-17T19:38:06ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01248728710.3390/ijms24087287Extracellular Vesicles for Therapeutic Nucleic Acid Delivery: Loading Strategies and ChallengesAnastasiya Oshchepkova0Marina Zenkova1Valentin Vlassov2Institute of Chemical Biology and Fundamental Medicine SB RAS, 630090 Novosibirsk, RussiaInstitute of Chemical Biology and Fundamental Medicine SB RAS, 630090 Novosibirsk, RussiaInstitute of Chemical Biology and Fundamental Medicine SB RAS, 630090 Novosibirsk, RussiaExtracellular vesicles (EVs) are membrane vesicles released into the extracellular milieu by cells of various origins. They contain different biological cargoes, protecting them from degradation by environmental factors. There is an opinion that EVs have a number of advantages over synthetic carriers, creating new opportunities for drug delivery. In this review, we discuss the ability of EVs to function as carriers for therapeutic nucleic acids (tNAs), challenges associated with the use of such carriers in vivo, and various strategies for tNA loading into EVs.https://www.mdpi.com/1422-0067/24/8/7287extracellular vesiclesdrug deliverynucleic acid therapeuticsnanocarrierexosomesapoptotic bodies |
| spellingShingle | Anastasiya Oshchepkova Marina Zenkova Valentin Vlassov Extracellular Vesicles for Therapeutic Nucleic Acid Delivery: Loading Strategies and Challenges International Journal of Molecular Sciences extracellular vesicles drug delivery nucleic acid therapeutics nanocarrier exosomes apoptotic bodies |
| title | Extracellular Vesicles for Therapeutic Nucleic Acid Delivery: Loading Strategies and Challenges |
| title_full | Extracellular Vesicles for Therapeutic Nucleic Acid Delivery: Loading Strategies and Challenges |
| title_fullStr | Extracellular Vesicles for Therapeutic Nucleic Acid Delivery: Loading Strategies and Challenges |
| title_full_unstemmed | Extracellular Vesicles for Therapeutic Nucleic Acid Delivery: Loading Strategies and Challenges |
| title_short | Extracellular Vesicles for Therapeutic Nucleic Acid Delivery: Loading Strategies and Challenges |
| title_sort | extracellular vesicles for therapeutic nucleic acid delivery loading strategies and challenges |
| topic | extracellular vesicles drug delivery nucleic acid therapeutics nanocarrier exosomes apoptotic bodies |
| url | https://www.mdpi.com/1422-0067/24/8/7287 |
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