Aggravated Gut Microbiota and Metabolomic Imbalances Are Associated with Hypertension Patients Comorbid with Atrial Fibrillation
Disordered gut microbiota (GM) as the co-contributor of atrial fibrillation (AF) and hypertension (HTN) might be associated with AF risk in HTN. This study aimed to explore the altered GM community and metabolic patterns between 27 HTN patients with AF (HTN-AF) and 27 non-AF HTN patients through fec...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/10/1445 |
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| author | Chen Fang Kun Zuo Yuan Fu Xiaoming Zhu Jing Li Jiuchang Zhong Li Xu Xinchun Yang |
| author_facet | Chen Fang Kun Zuo Yuan Fu Xiaoming Zhu Jing Li Jiuchang Zhong Li Xu Xinchun Yang |
| author_sort | Chen Fang |
| collection | DOAJ |
| description | Disordered gut microbiota (GM) as the co-contributor of atrial fibrillation (AF) and hypertension (HTN) might be associated with AF risk in HTN. This study aimed to explore the altered GM community and metabolic patterns between 27 HTN patients with AF (HTN-AF) and 27 non-AF HTN patients through fecal metagenomic and serum metabolomic analysis. Compared to non-AF HTN patients, significant microbial alterations (<i>p</i> = 0.004), including increased microbial diversity (<i>p</i> < 0.05), shifted enterotype dominated by <i>Prevotella</i> to <i>Bacteroides</i>, and abundant disease-linked genera <i>Ruminococcus</i>, <i>Streptococcus</i>, <i>Veillonella</i>, <i>Dorea</i>, and <i>Enterococcus</i>, were observed in HTN-AF patients. A species-based random forest prediction model was associated with the risk of AF occurrence in HTN patients. Furthermore, GM metabolic profiles dramatically differed between HTN and HTN-AF patients, especially the imbalance of saturated and unsaturated fatty acids. In HTN-AF patients, circulating palmitic acid and arachidonic acid levels were significantly elevated, while the levels of tetracosahexaenoic acid, oleic acid, linoleic acid, and stearic acid were decreased (<i>p</i> < 0.001, VIP > 1), mediating 85.99% of gut microbial indirect effects on AF (<i>p</i> < 0.001). Thus, our findings preliminarily indicated that exacerbated dysbiosis of GM and relevant metabolites was associated with high AF susceptibility and might be a potential target for AF prediction and prevention in HTN. |
| first_indexed | 2024-03-09T20:37:30Z |
| format | Article |
| id | doaj.art-fd045e8cb368417dab4afab24bf4f709 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T20:37:30Z |
| publishDate | 2022-10-01 |
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| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-fd045e8cb368417dab4afab24bf4f7092023-11-23T23:08:47ZengMDPI AGBiomolecules2218-273X2022-10-011210144510.3390/biom12101445Aggravated Gut Microbiota and Metabolomic Imbalances Are Associated with Hypertension Patients Comorbid with Atrial FibrillationChen Fang0Kun Zuo1Yuan Fu2Xiaoming Zhu3Jing Li4Jiuchang Zhong5Li Xu6Xinchun Yang7Heart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaHeart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaHeart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaHeart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaHeart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaHeart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaHeart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaHeart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaDisordered gut microbiota (GM) as the co-contributor of atrial fibrillation (AF) and hypertension (HTN) might be associated with AF risk in HTN. This study aimed to explore the altered GM community and metabolic patterns between 27 HTN patients with AF (HTN-AF) and 27 non-AF HTN patients through fecal metagenomic and serum metabolomic analysis. Compared to non-AF HTN patients, significant microbial alterations (<i>p</i> = 0.004), including increased microbial diversity (<i>p</i> < 0.05), shifted enterotype dominated by <i>Prevotella</i> to <i>Bacteroides</i>, and abundant disease-linked genera <i>Ruminococcus</i>, <i>Streptococcus</i>, <i>Veillonella</i>, <i>Dorea</i>, and <i>Enterococcus</i>, were observed in HTN-AF patients. A species-based random forest prediction model was associated with the risk of AF occurrence in HTN patients. Furthermore, GM metabolic profiles dramatically differed between HTN and HTN-AF patients, especially the imbalance of saturated and unsaturated fatty acids. In HTN-AF patients, circulating palmitic acid and arachidonic acid levels were significantly elevated, while the levels of tetracosahexaenoic acid, oleic acid, linoleic acid, and stearic acid were decreased (<i>p</i> < 0.001, VIP > 1), mediating 85.99% of gut microbial indirect effects on AF (<i>p</i> < 0.001). Thus, our findings preliminarily indicated that exacerbated dysbiosis of GM and relevant metabolites was associated with high AF susceptibility and might be a potential target for AF prediction and prevention in HTN.https://www.mdpi.com/2218-273X/12/10/1445atrial fibrillationhypertensionmetagenomemetabolomesaturated fatty acidsunsaturated fatty acids |
| spellingShingle | Chen Fang Kun Zuo Yuan Fu Xiaoming Zhu Jing Li Jiuchang Zhong Li Xu Xinchun Yang Aggravated Gut Microbiota and Metabolomic Imbalances Are Associated with Hypertension Patients Comorbid with Atrial Fibrillation Biomolecules atrial fibrillation hypertension metagenome metabolome saturated fatty acids unsaturated fatty acids |
| title | Aggravated Gut Microbiota and Metabolomic Imbalances Are Associated with Hypertension Patients Comorbid with Atrial Fibrillation |
| title_full | Aggravated Gut Microbiota and Metabolomic Imbalances Are Associated with Hypertension Patients Comorbid with Atrial Fibrillation |
| title_fullStr | Aggravated Gut Microbiota and Metabolomic Imbalances Are Associated with Hypertension Patients Comorbid with Atrial Fibrillation |
| title_full_unstemmed | Aggravated Gut Microbiota and Metabolomic Imbalances Are Associated with Hypertension Patients Comorbid with Atrial Fibrillation |
| title_short | Aggravated Gut Microbiota and Metabolomic Imbalances Are Associated with Hypertension Patients Comorbid with Atrial Fibrillation |
| title_sort | aggravated gut microbiota and metabolomic imbalances are associated with hypertension patients comorbid with atrial fibrillation |
| topic | atrial fibrillation hypertension metagenome metabolome saturated fatty acids unsaturated fatty acids |
| url | https://www.mdpi.com/2218-273X/12/10/1445 |
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