A novel role of lamins from genetic disease to cancer biomarkers
Lamins are the key components of the nuclear lamina and by virtue of their interactions with chromatin and binding partners act as regulators of cell proliferation and differentiation. Of late, the diverse roles of lamins in cellular processes have made them the topic of intense debate for their rol...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-11-01
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| Series: | Oncology Reviews |
| Subjects: | |
| Online Access: | http://www.oncologyreviews.org/index.php/or/article/view/309 |
| _version_ | 1797963120842375168 |
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| author | Kunnathur Murugesan Sakthivel Poonam Sehgal |
| author_facet | Kunnathur Murugesan Sakthivel Poonam Sehgal |
| author_sort | Kunnathur Murugesan Sakthivel |
| collection | DOAJ |
| description | Lamins are the key components of the nuclear lamina and by virtue of their interactions with chromatin and binding partners act as regulators of cell proliferation and differentiation. Of late, the diverse roles of lamins in cellular processes have made them the topic of intense debate for their role in cancer progression. The observations about aberrant localization or misexpression of the nuclear lamins in cancerous tissues have often led to the speculative role of lamins as a cancer risk biomarker. Here we discuss the involvement of lamins in several cancer subtypes and their potential role in predicting the tumor progression. |
| first_indexed | 2024-04-11T01:23:21Z |
| format | Article |
| id | doaj.art-fd046323ed1e4129a2e78a7ee7d1129d |
| institution | Directory Open Access Journal |
| issn | 1970-5557 1970-5565 |
| language | English |
| last_indexed | 2024-04-11T01:23:21Z |
| publishDate | 2016-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Oncology Reviews |
| spelling | doaj.art-fd046323ed1e4129a2e78a7ee7d1129d2023-01-03T10:55:49ZengFrontiers Media S.A.Oncology Reviews1970-55571970-55652016-11-0110210.4081/oncol.2016.309217A novel role of lamins from genetic disease to cancer biomarkersKunnathur Murugesan Sakthivel0Poonam Sehgal1Department of Biotechnology, Karunya University, Coimbatore, TamilnaduChemical and Biomolecular Engineering, University of Illinois, Urbana-Champaign, ILLamins are the key components of the nuclear lamina and by virtue of their interactions with chromatin and binding partners act as regulators of cell proliferation and differentiation. Of late, the diverse roles of lamins in cellular processes have made them the topic of intense debate for their role in cancer progression. The observations about aberrant localization or misexpression of the nuclear lamins in cancerous tissues have often led to the speculative role of lamins as a cancer risk biomarker. Here we discuss the involvement of lamins in several cancer subtypes and their potential role in predicting the tumor progression.http://www.oncologyreviews.org/index.php/or/article/view/309Lamin A/Clamin Bcancerbiomarker. |
| spellingShingle | Kunnathur Murugesan Sakthivel Poonam Sehgal A novel role of lamins from genetic disease to cancer biomarkers Oncology Reviews Lamin A/C lamin B cancer biomarker. |
| title | A novel role of lamins from genetic disease to cancer biomarkers |
| title_full | A novel role of lamins from genetic disease to cancer biomarkers |
| title_fullStr | A novel role of lamins from genetic disease to cancer biomarkers |
| title_full_unstemmed | A novel role of lamins from genetic disease to cancer biomarkers |
| title_short | A novel role of lamins from genetic disease to cancer biomarkers |
| title_sort | novel role of lamins from genetic disease to cancer biomarkers |
| topic | Lamin A/C lamin B cancer biomarker. |
| url | http://www.oncologyreviews.org/index.php/or/article/view/309 |
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